Transposon-based identification of a negative regulator for the antibiotic hyper-production in Streptomyces

The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis

(2017) Juan F Martín et al.   JOURNAL OF ANTIBIOTICS

Negative regulation of daptomycin production by DepR2, an ArsR-family transcriptional factor

(2017) Xu-Ming Mao et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Analysis of the Pho regulon in Streptomyces tsukubaensis

(2017) María Ordóñez-Robles et al.   MICROBIOLOGICAL RESEARCH

DepR1, a TetR Family Transcriptional Regulator, Positively Regulates Daptomycin Production in an Industrial Producer, Streptomyces roseosporus SW0702

(2016) Peng-Hui Yuan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genetic regulation and manipulation for natural product discovery

(2016) Jianwei Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes

(2016) María Ordóñez-Robles et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An overview on transcriptional regulators in Streptomyces

(2015) Alba Romero-Rodríguez et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Transcriptional Regulation of the Daptomycin Gene Cluster inStreptomyces roseosporusby an Autoregulator, AtrA

(2015) Xu-Ming Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DptR2, a DeoR-type auto-regulator, is required for daptomycin production in Streptomyces roseosporus

(2014) Feng Wang et al.   GENE

High-Efficiency Multiplex Genome Editing of Streptomyces Species Using an Engineered CRISPR/Cas System

(2014) Ryan E. Cobb et al.   ACS Synthetic Biology

Positive Feedback Regulation of stgR Expression for Secondary Metabolism in Streptomyces coelicolor

(2013) X.-M. Mao et al.   JOURNAL OF BACTERIOLOGY

Importance of microbial natural products and the need to revitalize their discovery

(2013) Arnold L. Demain   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

In vivo random mutagenesis of streptomycetes using mariner-based transposon Himar1

(2012) Bohdan Bilyk et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement

(2012) Di Huang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Improvement of A21978C production in Streptomyces roseosporus by reporter-guided rpsL mutation selection

(2012) L. Wang et al.   JOURNAL OF APPLIED MICROBIOLOGY

Diverse control of metabolism and other cellular processes in Streptomyces coelicolor by the PhoP transcription factor: genome-wide identification of in vivo targets

(2012) Nicholas E. E. Allenby et al.   NUCLEIC ACIDS RESEARCH

Metabolic Flux Analysis and Principal Nodes Identification for Daptomycin Production Improvement by Streptomyces roseosporus

(2011) Di Huang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Metabolic Engineering for the Production of Natural Products

(2011) Lauren B. Pickens et al.   Annual Review of Chemical and Biomolecular Engineering

Unexpected applications of secondary metabolites

(2010) Preeti Vaishnav et al.   BIOTECHNOLOGY ADVANCES

Daptomycin: From the Mountain to the Clinic, with Essential Help from Francis Tally, MD

(2010) Barry I. Eisenstein et al.   CLINICAL INFECTIOUS DISEASES

Daptomycin, a Bacterial Lipopeptide Synthesized by a Nonribosomal Machinery

(2010) Lars Robbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A transposon toolkit for gene transfer and mutagenesis in protozoan parasites

(2009) Jeziel D. Damasceno et al.   GENETICA

Reciprocal Regulation between SigK and Differentiation Programs in Streptomyces coelicolor

(2009) X.-M. Mao et al.   JOURNAL OF BACTERIOLOGY

The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis inStreptomyces ansochromogenes

(2009) Yuanyuan Pan et al.   MOLECULAR MICROBIOLOGY

Cross-talk between two global regulators in Streptomyces: PhoP and AfsR interact in the control of afsS, pstS and phoRP transcription

(2009) Fernando Santos-Beneit et al.   MOLECULAR MICROBIOLOGY

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Characterization of Replication and Conjugation of Streptomyces Circular Plasmids pFP1 and pFP11 and Their Ability To Propagate in Linear Mode with Artificially Attached Telomeres

(2008) R. Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production inStreptomyces coelicolor

(2008) Sean O'Rourke et al.   MOLECULAR MICROBIOLOGY