Hypoxia signalling manipulation for bone regeneration

The effect of simvastatin on chemotactic capability of SDF-1α and the promotion of bone regeneration

(2014) Yun-Song Liu et al.   BIOMATERIALS

Therapeutic Effect of Deferoxamine on Iron Overload-Induced Inhibition of Osteogenesis in a Zebrafish Model

(2014) Bin Chen et al.   CALCIFIED TISSUE INTERNATIONAL

Thalassemia Bone Disease: A 19-Year Longitudinal Analysis

(2014) Phillip Wong et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

The Role of Hypoxia-Inducible Factor in Wound Healing

(2014) Wan Xing Hong et al.   Advances in Wound Care

A small molecule approach to engineering vascularized tissue

(2013) Joyce Doorn et al.   BIOMATERIALS

Deferoxamine expedites consolidation during mandibular distraction osteogenesis

(2013) Alexis Donneys et al.   BONE

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A Novel Prolyl Hydroxylase Inhibitor Protects Against Cell Death After Hypoxia

(2013) Satoru Kontani et al.   NEUROCHEMICAL RESEARCH

Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures

(2013) P. Wong et al.   OSTEOPOROSIS INTERNATIONAL

Deferoxamine Administration Delivers Translational Optimization of Distraction Osteogenesis in the Irradiated Mandible

(2013) Peter A. Felice et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Deferoxamine Restores Callus Size, Mineralization, and Mechanical Strength in Fracture Healing after Radiotherapy

(2013) Alexis Donneys et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Dimethyloxaloylglycine Increases the Bone Healing Capacity of Adipose-Derived Stem Cells by Promoting Osteogenic Differentiation and Angiogenic Potential

(2013) Hao Ding et al.   STEM CELLS AND DEVELOPMENT

Deferoxamine reverses radiation induced hypovascularity during bone regeneration and repair in the murine mandible

(2012) Aaron S. Farberg et al.   BONE

Localized deferoxamine injection augments vascularity and improves bony union in pathologic fracture healing after radiotherapy

(2012) Alexis Donneys et al.   BONE

The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO

(2012) Erinn B. Rankin et al.   CELL

An evaluation of carrier agents for desferoxamine, an up-regulator of vascular endothelial growth factor

(2012) Brian P Hertzberg et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men: A 3-year retrospective longitudinal study

(2012) Beom-Jun Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases

(2012) Eun A. Cho et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Recent agents targeting HIF-1α for cancer therapy

(2012) Yaozhong Hu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

(2012) Yanqiu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)

(2012) Shannon C. Flagg et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

New bone formation in a true bone ceramic scaffold loaded with desferrioxamine in the treatment of segmental bone defect: a preliminary study

(2012) Weibin Zhang et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

Hypoxia-driven pathways in bone development, regeneration and disease

(2012) Christa Maes et al.   Nature Reviews Rheumatology

Fracture healing under healthy and inflammatory conditions

(2012) Lutz Claes et al.   Nature Reviews Rheumatology

Deferoxamine Enhances the Vascular Response of Bone Regeneration in Mandibular Distraction Osteogenesis

(2012) Alexis Donneys et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Repairing critical-sized calvarial defects with BMSCs modified by a constitutively active form of hypoxia-inducible factor-1α and a phosphate cement scaffold

(2011) Duohong Zou et al.   BIOMATERIALS

Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering

(2011) Chengtie Wu et al.   BIOMATERIALS

Blood vessel formation in the tissue-engineered bone with the constitutively active form of HIF-1α mediated BMSCs

(2011) Duohong Zou et al.   BIOMATERIALS

Increasing Vascularity to Improve Healing of a Segmental Defect of the Rat Femur

(2011) Rena Stewart et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

(2011) Elisa Araldi et al.   NATURE MEDICINE

The Tunica Adventitia of Human Arteries and Veins As a Source of Mesenchymal Stem Cells

(2011) Mirko Corselli et al.   STEM CELLS AND DEVELOPMENT

Role of HIF-1α in skeletal development

(2010) Chao Wan et al.   Annals of the New York Academy of Sciences

Acidosis, hypoxia and bone

(2010) Timothy R. Arnett   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Enhancing in vivo vascularized bone formation by cobalt chloride-treated bone marrow stromal cells in a tissue engineered periosteum model

(2010) Wei Fan et al.   BIOMATERIALS

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

Hypoxia stimulates osteoclast formation from human peripheral blood

(2010) Jennifer C. Utting et al.   CELL BIOCHEMISTRY AND FUNCTION

Cancer Therapy By Targeting Hypoxia-Inducible Factor-1

(2010) Y. Li et al.   CURRENT CANCER DRUG TARGETS

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

(2010) Lin Yan et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4

(2010) Helen J. Knowles et al.   FASEB JOURNAL

Inhibition of osteoclastogenesis by prolyl hydroxylase inhibitor dimethyloxallyl glycine

(2010) Andrew J. Leger et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Mesenchymal stem cells: From bench to bedside

(2010) Teng Ma   World Journal of Stem Cells

Therapeutic Manipulation of the HIF Hydroxylases

(2009) Simon Nagel et al.   ANTIOXIDANTS & REDOX SIGNALING

Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model

(2009) Toshiyuki Kitaori et al.   ARTHRITIS AND RHEUMATISM

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

(2009) Christa Maes et al.   EMBO JOURNAL

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

(2009) Ernestina Schipani et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypoxia-inducible factors 1α and 2α exert both distinct and overlapping functions in long bone development

(2009) Stacy H. Shomento et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role of hypoxia-inducible factor-1α in angiogenic–osteogenic coupling

(2009) Ryan C. Riddle et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice

(2009) Xing Shen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis

(2009) Helen J Knowles et al.   JOURNAL OF PATHOLOGY

Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications

(2008) Elizabeth L. Mackenzie et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of soluble cobalt and cobalt incorporated into calcium phosphate layers on osteoclast differentiation and activation

(2008) Somying Patntirapong et al.   BIOMATERIALS

Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia

(2008) Ellen B. Fung et al.   BONE

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Fracture vascularity and bone healing: A systematic review of the role of VEGF

(2008) N.C. Keramaris et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Bone Disease in Thalassemia: A Frequent and Still Unresolved Problem

(2008) Maria G Vogiatzi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Expression and significance of hypoxemia-inducible factor-1α in osteosarcoma of the jaws

(2008) Wei-liang Chen et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

Activation of the hypoxia-inducible factor-1  pathway accelerates bone regeneration

(2008) C. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1α and erythropoietin

(2008) Yun-Xia Li et al.   Neuroscience Bulletin

Circulating Bone Marrow-Derived Osteoblast Progenitor Cells Are Recruited to the Bone-Forming Site by the CXCR4/Stromal Cell-Derived Factor-1 Pathway

(2007) Satoru Otsuru et al.   STEM CELLS