Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment

Inhibition of Lymphangiogenesis and Angiogenesis in Breast Tumor Xenografts and Lymph Nodes by a Peptide Derived from Transmembrane Protein 45A

(2015) Esak Lee et al.   NEOPLASIA

Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis

(2014) Esak Lee et al.   Nature Communications

Endothelium-dependent epithelial–mesenchymal transition of tumor cells: Exclusive roles of transforming growth factor β1 and β2

(2013) Chiwaka Kimura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response

(2013) Susan N. Thomas et al.   BIOMATERIALS

Stromal fibroblasts in the microenvironment of gastric carcinomas promote tumor metastasis via upregulating TAGLN expression

(2013) Beiqin Yu et al.   BMC CELL BIOLOGY

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma

(2013) Xiang H.-F. Zhang et al.   CELL

Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model

(2013) Luca Quagliata et al.   CLINICAL & EXPERIMENTAL METASTASIS

Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model

(2013) Esak Lee et al.   CLINICAL & EXPERIMENTAL METASTASIS

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects

(2013) Elena A. Goncharova   FASEB JOURNAL

Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy in Patients With Node-Positive Breast Cancer

(2013) Judy C. Boughey   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor and its microenvironment: A synergistic interplay

(2013) Veronica Catalano et al.   SEMINARS IN CANCER BIOLOGY

Targeting Angiogenesis and the Tumor Microenvironment

(2013) Jennifer Samples et al.   Surgical Oncology Clinics of North America

‘Cancer associated fibroblasts’ – more than meets the eye

(2013) Shalom Madar et al.   TRENDS IN MOLECULAR MEDICINE

A Role for Angiopoietin-2 in Organ-Specific Metastasis

(2013) Nicolò Rigamonti et al.   Cell Reports

Synergy between a collagen IV mimetic peptide and a somatotropin-domain derived peptide as angiogenesis and lymphangiogenesis inhibitors

(2012) Jacob E. Koskimaki et al.   ANGIOGENESIS

Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy

(2012) M. A. Swartz et al.   CANCER RESEARCH

The connectivity of lymphogenous and hematogenous tumor cell dissemination: biological insights and clinical implications

(2012) Jonathan P. Sleeman et al.   CLINICAL & EXPERIMENTAL METASTASIS

Tumor microenvironment: a main actor in the metastasis process

(2012) Daniela Spano et al.   CLINICAL & EXPERIMENTAL METASTASIS

Tumor microenvironment regulates epithelial–mesenchymal transitions in metastasis

(2012) Dingcheng Gao et al.   Expert Review of Anticancer Therapy

Emerging insights into head and neck cancer metastasis

(2012) Clint T. Allen et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Changes in specialized blood vessels in lymph nodes and their role in cancer metastasis

(2012) Ser Yee Lee et al.   Journal of Translational Medicine

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

New insights into the mechanisms of organ-specific breast cancer metastasis

(2012) Girieca Lorusso et al.   SEMINARS IN CANCER BIOLOGY

CCL7 and CCL21 overexpression in gastric cancer is associated with lymph node metastasis and poor prognosis

(2012) Tsann-Long Hwang   WORLD JOURNAL OF GASTROENTEROLOGY

The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination

(2012) M. Labelle et al.   Cancer Discovery

A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth

(2011) R. H. Farnsworth et al.   CANCER RESEARCH

Decreased Lymphangiogenesis and Lymph Node Metastasis by mTOR Inhibition in Head and Neck Cancer

(2011) V. Patel et al.   CANCER RESEARCH

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway

(2011) Eva Maria Galan-Moya et al.   EMBO REPORTS

Incidence of lymph node and adnexal metastasis in endometrial stromal sarcoma

(2011) Lisa A. dos Santos et al.   GYNECOLOGIC ONCOLOGY

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

(2011) Raghu P. Kataru et al.   IMMUNITY

Small peptides derived from somatotropin domain-containing proteins inhibit blood and lymphatic endothelial cell proliferation, migration, adhesion and tube formation

(2011) Esak Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cross-talk between endothelial and breast cancer cells regulates reciprocal expression of angiogenic factors in vitro

(2011) Cara F. Buchanan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

(2011) Dontscho Kerjaschki et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor–resistant human lung adenocarcinoma

(2011) Tina Cascone et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphatic and blood vessels in basal and triple-negative breast cancers: characteristics and prognostic significance

(2011) Rabab A A Mohammed et al.   MODERN PATHOLOGY

Lymphangiogenesis in post-natal tissue remodeling: Lymphatic endothelial cell connection with its environment

(2011) Jenny Paupert et al.   MOLECULAR ASPECTS OF MEDICINE

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

Endothelial derived factors inhibit anoikis of head and neck cancer stem cells

(2011) Marcia S. Campos et al.   ORAL ONCOLOGY

Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics

(2010) Qun Lin et al.   CANCER BIOLOGY & THERAPY

CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche

(2010) M. Kim et al.   CANCER RESEARCH

Endothelial Cell-Initiated Signaling Promotes the Survival and Self-Renewal of Cancer Stem Cells

(2010) S. Krishnamurthy et al.   CANCER RESEARCH

In vivo Dynamics and Distinct Functions of Hypoxia in Primary Tumor Growth and Organotropic Metastasis of Breast Cancer

(2010) X. Lu et al.   CANCER RESEARCH

Angiocrine Factors Modulate Tumor Proliferation and Motility through EphA2 Repression of Slit2 Tumor Suppressor Function in Endothelium

(2010) D. M. Brantley-Sieders et al.   CANCER RESEARCH

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts

(2010) Antti I. Nykänen et al.   CIRCULATION

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

(2010) Hideki Kobayashi et al.   NATURE CELL BIOLOGY

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Trafficking properties of plasmacytoid dendritic cells in health and disease

(2010) Silvano Sozzani et al.   TRENDS IN IMMUNOLOGY

PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment

(2009) Yongping Crawford et al.   CANCER CELL

Altered phenotype of lymphatic endothelial cells induced by highly metastatic OTSCC cells contributed to the lymphatic metastasis of OTSCC cells

(2009) Zhang Zhuang et al.   CANCER SCIENCE

Myeloid-derived suppressor cells in inflammation: Uncovering cell subsets with enhanced immunosuppressive functions

(2009) Vincenzo Bronte   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells

(2009) Ofer Fainaru et al.   FASEB JOURNAL

Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer

(2009) Toshiaki Hirasawa et al.   Gastric Cancer

CD151 Regulates Tumorigenesis by Modulating the Communication between Tumor Cells and Endothelium

(2009) R. Sadej et al.   MOLECULAR CANCER RESEARCH

Biomarkers of response and resistance to antiangiogenic therapy

(2009) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Immune infiltration in human tumors: a prognostic factor that should not be ignored

(2009) F Pagès et al.   ONCOGENE

A Macrophage Gene Expression Signature Defines a Field Effect in the Lung Tumor Microenvironment

(2008) R. S. Stearman et al.   CANCER RESEARCH

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Breast Tumor Microenvironment: Proteomics Highlights the Treatments Targeting Secretome

(2008) Shui-Tein Chen et al.   JOURNAL OF PROTEOME RESEARCH

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Co-evolution of tumor cells and their microenvironment

(2008) Kornelia Polyak et al.   TRENDS IN GENETICS

Endothelial Cells Enhance Tumor Cell Invasion through a Crosstalk Mediated by CXC Chemokine Signaling

(2008) Kristy A. Warner et al.   NEOPLASIA