The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas

Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia

(2015) Xi Wang et al.   CELLULAR SIGNALLING

Cell-SELEX-based selection of aptamers that recognize distinct targets on metastatic colorectal cancer cells

(2014) Wan-Ming Li et al.   BIOMATERIALS

Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer

(2014) Xiongwei Deng et al.   BIOMATERIALS

MicroRNA-34a overcomes HGF-mediated gefitinib resistance in EGFR mutant lung cancer cells partly by targeting MET

(2014) Jian-Ya Zhou et al.   CANCER LETTERS

MiR-34a regulates therapy resistance by targeting HDAC1 and HDAC7 in breast cancer

(2014) Mei-Yi Wu et al.   CANCER LETTERS

Targeting of miR34a-NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance

(2014) E. Y. Park et al.   CANCER RESEARCH

Aberrant Regulation and Function of MicroRNAs in Cancer

(2014) Brian D. Adams et al.   CURRENT BIOLOGY

Extracellular Disposal of Tumor-Suppressor miRs-145 and -34a via Microvesicles and 5-FU Resistance of Human Colon Cancer Cells

(2014) Yukihiro Akao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

(2014) Matjaz Rokavec et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic Delivery of a miR34a Mimic as a Potential Therapeutic for Liver Cancer

(2014) C. L. Daige et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

(2014) Christopher J. Cheng et al.   NATURE

miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110

(2014) Rui Song et al.   NATURE

Correction: Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway

(2014) Rong Shi et al.   PLoS One

Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis

(2014) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small RNA combination therapy for lung cancer

(2014) W. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-34a is an intracellular and exosomal predictive biomarker for response to docetaxel with clinical relevance to prostate cancer progression

(2014) Claire Corcoran et al.   PROSTATE

MicroRNA-34a: a potential therapeutic target in human cancer

(2014) X J Li et al.   Cell Death & Disease

Altering β-cell number through stable alteration of miR-21 and miR-34a expression

(2014) Marie Balslev Backe et al.   Islets

Cell-type-specific, Aptamer-functionalized Agents for Targeted Disease Therapy

(2014) Jiehua Zhou et al.   Molecular Therapy-Nucleic Acids

Mir-34: A New Weapon Against Cancer?

(2014) Gabriella Misso et al.   Molecular Therapy-Nucleic Acids

A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells

(2013) Pengcheng Bu et al.   Cell Stem Cell

Deregulated Serum Concentrations of Circulating Cell-Free MicroRNAs miR-17, miR-34a, miR-155, and miR-373 in Human Breast Cancer Development and Progression

(2013) C. Eichelser et al.   CLINICAL CHEMISTRY

Dysregulation of MicroRNA-34a Expression in Colorectal Cancer Inhibits the Phosphorylation of FAK Via VEGF

(2013) Danhua Zhang et al.   DIGESTIVE DISEASES AND SCIENCES

Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis

(2013) Arash Javeri et al.   MEDICAL ONCOLOGY

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

First microRNA mimic enters clinic

(2013) Aaron Bouchie   NATURE BIOTECHNOLOGY

Epigenetic Regulation of miR-34a Expression in Alcoholic Liver Injury

(2012) Fanyin Meng et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA-34a Modulates Chemosensitivity of Breast Cancer Cells to Adriamycin by Targeting Notch1

(2012) Xiu-juan Li et al.   ARCHIVES OF MEDICAL RESEARCH

miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma

(2012) A. L. Kasinski et al.   CANCER RESEARCH

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1

(2012) Laisheng Li et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Detection of miR-34a Promoter Methylation in Combination with Elevated Expression of c-Met and  -Catenin Predicts Distant Metastasis of Colon Cancer

(2012) H. Siemens et al.   CLINICAL CANCER RESEARCH

MiR-34a inhibits lipopolysaccharide-induced inflammatory response through targeting Notch1 in murine macrophages

(2012) Pei Jiang et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway

(2012) Jianqiang Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF

(2012) Sanchita Roy et al.   Journal of Hematology & Oncology

CirculatingmiR-34alevels are reduced in colorectal cancer

(2012) M. Nugent et al.   JOURNAL OF SURGICAL ONCOLOGY

The quantitative analysis by stem-loop real-time PCR revealed the microRNA-34a, microRNA-155 and microRNA-200c overexpression in human colorectal cancer

(2012) Mojin Wang et al.   MEDICAL ONCOLOGY

Dysregulation of MicroRNA-34a Expression in Head and Neck Squamous Cell Carcinoma Promotes Tumor Growth and Tumor Angiogenesis

(2012) Bhavna Kumar et al.   PLoS One

CD95 Is Part of a Let-7/p53/miR-34 Regulatory Network

(2012) Annika Hau et al.   PLoS One

Intact p53-Dependent Responses in miR-34–Deficient Mice

(2012) Carla P. Concepcion et al.   PLoS Genetics

Novel strategies targeting cancer stem cells through phytochemicals and their analogs

(2012) Prasad Dandawate et al.   Drug Delivery and Translational Research

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

Myc-mediated repression of microRNA-34a promotes high-grade transformation of B-cell lymphoma by dysregulation of FoxP1

(2011) V. J. Craig et al.   BLOOD

Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA

(2011) Mark Mackiewicz et al.   BREAST CANCER RESEARCH AND TREATMENT

miRNA-34a is associated with docetaxel resistance in human breast cancer cells

(2011) L. Kastl et al.   BREAST CANCER RESEARCH AND TREATMENT

DNA hypermethylation of microRNA-34b/c has prognostic value for stage Ⅰ non-small cell lung cancer

(2011) Zhen Wang et al.   CANCER BIOLOGY & THERAPY

MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1

(2011) Jianmin Wu et al.   CARCINOGENESIS

Introduction

(2011) SAMSON T. JACOB   GENE EXPRESSION

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-449 inhibits cell proliferation and is down-regulated in gastric cancer

(2011) Tony Bou Kheir et al.   Molecular Cancer

miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner

(2011) Nora Bandi et al.   Molecular Cancer

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

Erratum: Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

(2011) Brice Marcet et al.   NATURE CELL BIOLOGY

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas

(2011) Markus Vogt et al.   VIRCHOWS ARCHIV

C/EBP  regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations

(2010) J. A. Pulikkan et al.   BLOOD

Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells

(2010) Yukihiro Akao et al.   CANCER LETTERS

Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34

(2010) J. F. Wiggins et al.   CANCER RESEARCH

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

(2010) Dmitri Lodygin et al.   CELL CYCLE

Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia

(2010) Olaf Merkel et al.   CELL CYCLE

MicroRNA-34a Inhibits Cell Proliferation by Repressing Mitogen-Activated Protein Kinase Kinase 1 during Megakaryocytic Differentiation of K562 Cells

(2010) A. Ichimura et al.   MOLECULAR PHARMACOLOGY

MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms

(2010) Keitaro Kojima et al.   PROSTATE

The impact of miR-34a on protein output in hepatocellular carcinoma HepG2 cells

(2010) Jun Cheng et al.   PROTEOMICS

Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages

(2010) Tokuo Sukata et al.   TOXICOLOGY LETTERS

miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53

(2009) F. Navarro et al.   BLOOD

miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer

(2009) Elena Gallardo et al.   CARCINOGENESIS

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

MicroRNA Involvement in the Pathogenesis of Neuroblastoma: Potential for MicroRNA Mediated Therapeutics

(2009) R. Stallings   CURRENT PHARMACEUTICAL DESIGN

miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A

(2009) X. Yang et al.   GENES & DEVELOPMENT

miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities

(2009) M Mraz et al.   LEUKEMIA

The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells

(2009) M Kato et al.   ONCOGENE

Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells

(2008) Yasunori Fujita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells

(2008) Na Li et al.   CANCER LETTERS

Alterations in MicroRNA Expression Contribute to Fatty Acid-Induced Pancreatic  -Cell Dysfunction

(2008) P. Lovis et al.   DIABETES

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation

(2008) M K Dijkstra et al.   LEUKEMIA

Down-regulation of the microRNAsmiR-34a,miR-127, andmiR-200bin rat liver during hepatocarcinogenesis induced by a methyl-deficient diet

(2008) Volodymyr P. Tryndyak et al.   MOLECULAR CARCINOGENESIS

Lung Cancer

(2008) Roy S. Herbst et al.   NEW ENGLAND JOURNAL OF MEDICINE

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA