Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Oncology
Maral Jamshidi, Rainer Fagerholm, Taru A. Muranen, Sippy Kaur, Swapnil Potdar, Sofia Khan, Eliisa Netti, John-Patrick Mpindi, Bhagwan Yadav, Johanna Kiiski, Kristiina Aittomaki, Paivi Heikkila, Jani Saarela, Ralf Butzow, Carl Blomqvist, Heli Nevanlinna
Summary: A comprehensive study on the role of the miR-30 family in breast cancer revealed that high miR-30d expression is associated with improved survival in aggressive tumor phenotypes. Drug sensitivity analysis showed that ectopic expression of miR-30 family members sensitized breast cancer cell lines to treatment. Pathway analysis suggested that the miR-30 family may inhibit pathways contributing to EMT and metastasis in breast cancer.
Article
Pharmacology & Pharmacy
Selase Ativui, Cynthia A. Danquah, Paul Poku Sampene Ossei, Michael Ofori
Summary: This study demonstrated that palmatine has the potential to improve hypoxemia, ameliorate metastasis-associated lung injury, decrease lung MTA1 expression, and increase p53 expression in the treatment of lung metastasis from triple negative breast cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Jinhui Lue, Qian Zhao, Yuefan Guo, Danni Li, Heying Xie, Cuicui Liu, Xin Hu, Suling Liu, Zhaoyuan Hou, Xunbin Wei, Deyou Zheng, Richard G. Pestell, Zuoren Yu
Summary: This study identified a miR-29a-PTEN-AKT axis as a downstream signaling pathway of ER alpha in breast cancer metastasis. Low level of miR-29a was associated with reduced metastasis and better survival in ER alpha+ luminal subtype of BC, while high level of miR-29a was detected in ER alpha- triple negative breast cancer (TNBC) with distant metastasis and poor survival. Targeting miR-29a suppressed cellular invasion, EMT and lung metastasis in TNBC cells in vitro and in TNBC tumor-bearing mice in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Ziqi Yu, Xue Dong, Mei Song, Aizhang Xu, Qing He, Huilin Li, Wen Ouyang, Lotfi Chouchane, Xiaojing Ma
Summary: This study demonstrates the important role of UBR5 in driving breast cancer metastasis by regulating the CDC73 and p53 pathways, affecting tumor cell apoptosis and proliferation. It provides a potential target for cancer therapy.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Mirko Minini, Alice Senni, Xingkang He, Sara Proietti, Domenico Liguoro, Angela Catizone, Alessandro Giuliani, Rita Mancini, Andrea Fuso, Alessandra Cucina, Yihai Cao, Mariano Bizzarri
Summary: Myo-Inositol inhibits the PI3K/Akt pathway, particularly effective in triple-negative breast cancer cells, but not in hormone-responsive breast cancer cells unless estrogen effects are counteracted. This novel axis involving miR-125a-5p downregulating IP(6)K1 gene could be activated as a molecular target therapy in breast cancer, inhibiting metastasis and tumor progression.
Article
Biochemistry & Molecular Biology
Jhih-Kai Pan, Cheng-Han Lin, Yao-Lung Kuo, Luo-Ping Ger, Hui-Chuan Cheng, Yun-Chin Yao, Michael Hsiao, Pei-Jung Lu
Summary: The study identified high levels of miR-211 as a prognostic marker for breast cancer brain metastasis, enhancing trans-blood-brain barrier migration and adherence of tumor cells leading to brain colonization and poor survival outcomes. Furthermore, downstream targets of miR-211, SOX11 and NGN2, play a role in regulating TNBC brain metastasis.
Article
Biochemistry & Molecular Biology
Zekai Huang, Markus Kaller, Heiko Hermeking
Summary: miR-34a and miR-34b/c, as direct targets of p53, play a crucial role in the tumor suppressive effects of p53. Inactivating miR-34a and/or miR-34b/c in colorectal cancer cell line HCT116 had significant effects on proliferation, migration, invasion, chemosensitivity, autophagy, and apoptosis. The concomitant deletion of miR-34a and miR-34b/c resulted in EMT signature enrichment, impaired gene repression by the p53-DREAM pathway, and elevated autophagy. A gene signature upregulated in cells with combined inactivation of miR-34a and miR-34b/c was associated with invasive colon cancer subtype CMS4, poor overall survival in CRC patients, and 5-FU resistance in CRC cell lines.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Oncology
Poonam Yadav, Priyanshu Sharma, Sandhya Sundaram, Ganesh Venkatraman, Amal Kanti Bera, Devarajan Karunagaran
Summary: miR-5096 induces ferroptotic cell death in breast cancer cells by targeting and downregulating SLC7A11, reducing ROS, lipid peroxides, and iron accumulation levels, as well as decreasing GSH levels and mitochondrial membrane potential, inhibiting cell survival, migration, and invasion.
Article
Chemistry, Medicinal
Dipti Kanabar, Mimansa Goyal, Emma Kane, Tejashri Chavan, Abbas Kabir, Xuechun Wang, Snehal Shukla, Joseph Almasri, Sona Goswami, Gizem Osman, Marino Kokolis, Donald E. Spratt, Vivek Gupta, Aaron Muth
Summary: This study reports the structure-based design of small molecules that can bind to Gankyrin and inhibit its overexpression in breast and lung cancers, showing potential therapeutic value.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Sevan Omer Majed, Suhad Asad Mustafa
Summary: This study aimed to identify differentially expressed genes and ncRNAs in breast cancer tissues compared to normal adjacent tissues, and found miR-4510 as a potential biomarker for breast cancer. The study used MACE-Seq and small RNA-Seq to analyze gene expression and identified miR-4510 as significantly down-regulated in breast cancer. Experimental data suggested that miR-4510 may function as a tumor suppressor in breast cancer.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Zhaoze Guo, Han Zhang, Yiming Fu, Junjie Kuang, Bei Zhao, LanFang Zhang, Jie Lin, Shuhui Lin, Dehua Wu, Guozhu Xie
Summary: Cancer-associated fibroblasts (CAFs) are the most common stromal cells in breast cancer, and they play a role in disease progression and chemoresistance. This study found that CAF-derived conditioned media can promote breast cancer cell growth and radioresistance. The secretion of interleukin 6 (IL-6) by CAFs activates the STAT3 signaling pathway, leading to the growth and radioresistance of breast cancer cells. Inhibition of STAT3 or neutralizing IL-6 can block the effects induced by CAFs. In mouse models, the IL-6 receptor monoclonal antibody tocilizumab can reverse CAF-induced growth and radioresistance. Additionally, poor response to radiotherapy in breast cancer is associated with the expression of IL-6 and p-STAT3. These findings highlight the importance of the IL-6/STAT3 signaling pathway as a potential therapeutic target in breast cancer radiotherapy.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Sergey E. Parfenyev, Sergey V. Shabelnikov, Elena N. Tolkunova, Nickolai A. Barlev, Alexey G. Mittenberg
Summary: P53 plays a critical role in protecting the genome and preventing tumor formation, including metastases. The interaction between p53 and the transcription factor Zeb1 is important in carcinogenesis, particularly in the process of epithelial to mesenchymal transition (EMT). Additionally, the composition of Zeb1 interactome is affected by the presence of cancer stem cells and the level of Oct4/Sox2 expression, indicating that stemness influences the specificity of Zeb1 interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ya Fan, Jia Wang, Wen Jin, Yifei Sun, Yuemei Xu, Yipin Wang, Xiubin Liang, Dongming Su
Summary: The study revealed that HRD1 is significantly underexpressed in triple-negative breast cancer (TNBC) and inhibits cancer progression by inducing proteasomal degradation of Vimentin. CircNR3C2 is also downregulated in TNBC and enhances the tumor-suppressive effects of HRD1 through sponging miR-513a-3p. This circNR3C2/miR-513a-3p/HRD1/Vimentin axis negatively regulates TNBC metastasis and may serve as potential prognostic biomarkers for aggressive breast cancer.
Article
Biochemistry & Molecular Biology
Bo Fu, Wei Liu, Cui Zhu, Peng Li, Li Wang, Li Pan, Ke Li, Peiying Cai, Min Meng, Yiting Wang, Anqi Zhang, Wenqiang Tang, Meng An
Summary: CircBCBM1 is involved in breast cancer brain metastasis through the circBCBM1/miR-125a/BRD4 axis, and it may serve as a novel diagnostic and prognostic biomarker and potential therapeutic target for breast cancer brain metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Susan Nabilou, Fatemeh Pak, Zahra Alizadeh, Mohammad Reza Fazlollahi, Masoud Houshmand, Maryam Ayazi, Iraj Mohammadzadeh, Mohammad Hasan Bemanian, Abbas Fayezi, Mohammad Nabavi, Shiva Saghafi, Sajedeh Mohammadian, Parviz Kokhaei, Mostafa Moin, Zahra Pourpak
Summary: This study aimed to define the genetic spectrum of HAE type I and type II among Iranian patients. Mutations in SERPING1 were analyzed using PCR and Sanger Sequencing, leading to the identification of 14 pathogenic variations, including 3 novel mutations. Genetic diagnosis plays a significant role in early diagnosis and prevention of potential risks associated with HAE.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Letter
Immunology
Zahra Alizadeh, Susan Nabilou, Marzieh Mazinani, Shaghayegh Tajik, Amir Ali Hamidieh, Masoud Houshmand, Mohammad Reza Fazlollahi, Zahra Pourpak
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hormoz Selahvarzi, Milad Kamdideh, Mehrnoosh Vahabi, Ali Dezhgir, Massoud Houshmand, Soha Sadeghi
Summary: This study identified a significant relationship between two polymorphisms, Rs1544410 and rs4646536, in the VDR and CYP27B1 genes and an increased risk of developing vitamin D3 insufficiency in the Iranian population. These SNPs can be considered as prognostic biomarkers for the risk of vitamin D3 deficiency.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2021)
Article
Allergy
Leila Shakerian, Maryam Nourizadeh, Mohsen Badalzadeh, Mohammad Reza Fazlollahi, Raheleh Shokouhi Shoormasti, Shiva Saghafi, Behnaz Esmaeili, Zahra Alizadeh, Stephan Borte, Massoud Houshmand, Lennart Hammarstrom, Zahra Pourpak
Summary: This study investigated the alterations of TREC and KREC biomarkers in 82 PID patients with different genetic diagnoses, and found a significant difference in both markers compared to age-matched healthy controls. Patients with CVID, AT, WAS, DOCKS deficiency, and HIES with unknown genetic defects showed very low to zero amounts of TREC and/or KREC, while STAT3-deficient patients were normal for both biomarkers.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rezvan Abtahi, Parvaneh Karimzadeh, Alireza Rezayi, Shadab Salehpour, Diba Akbarzadeh, Seyed Hassan Tonekaboni, Reza Zolfaghari Emameh, Massoud Houshmand
Summary: The study provided additional insights into the genotype of sphingolipidoses diseases among Iranian patients, identifying novel mutations and expanding the genotypic spectrum for MLD, SD, TSD, and NPD disorders. This research can potentially lead to the development of more effective methods for genetic carrier detection, diagnosis, and counseling of affected Iranian patients.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Oncology
Atefeh Zamani, Nasrin Fattahi Dolatabadi, Massoud Houshmand, Nasrinsadat Nabavizadeh
Summary: The study identified miR-324-3p and miR-5085p as potential regulators of ABCA3 expression in childhood ALL, with low expression in pediatric ALL patients compared to non-cancer controls. MiR-508-5p showed promise as a relapsed indicator in childhood ALL, potentially influencing novel therapeutic strategies and acting as a diagnostic and drug-resistant biomarker.
Article
Anatomy & Morphology
Reyhaneh Afshar-Khamseh, Arash Javeri, Masoumeh Fakhr Taha
Summary: CXCR4 plays a crucial role in colorectal cancer development and metastasis, and the downregulation of CXCR4 by miR-146a affects proliferation, apoptosis, and migration of CRC cells. While the overexpression of miR-146a leads to cell cycle arrest and decreased apoptosis, it may not universally suppress tumor growth in all CRC cells.
Article
Multidisciplinary Sciences
Parisa Veiskarami, Massoud Houshmand, Sharareh Seifi, Nafiseh Ansarinejad, Farshid Fardad, Bahareh Abbasi
Summary: The study revealed a significant association between the CHRNA3 rs1051730C > T variant and the risk of developing lung cancer, as well as nicotine dependence in the Iranian population. However, no association was found for the ABCB1 rs3842A > G variant. These results suggest that the CHRNA3 rs1051730C > T variant may modify susceptibility to lung cancer among Iranians through a smoking-dependent mechanism.
Article
Biochemistry & Molecular Biology
Anousheh Shasttiri, Misagh Moridi, Abbas Safari, Sayed Haidar Abbas Raza, Mostafa Ghaderi-Zefrehei, Massoud Houshmand, Ahmad Oryan, Mohammad Hossein Sanati, Jacqueline Smith, Motahareh Amjadi
Summary: The Iranian gene pool exhibits high haplogroup diversities and admixture of exotic groups, with the Arab subpopulation being independent from the others. Thalassemia patients showed some significant differences in their HVS2 sequence.
BIOCHEMICAL GENETICS
(2022)
Article
Virology
Peyman Taghizadeh, Sadegh Salehi, Ali Heshmati, Seyed Massoud Houshmand, Kolsoum InanlooRahatloo, Forouzandeh Mahjoubi, Mohammad Hossein Sanati, Hadi Yari, Afagh Alavi, Saeid Amel Jamehdar, Soroosh Dabiri, Hamid Galehdari, Mohammad Reza Haghshenas, Amir Masoud Hashemian, Abtin Heidarzadeh, Issa Jahanzad, Elham Kheyrani, Ahmad Piroozmand, Ali Mojtahedi, Hadi Razavi Nikoo, Mohammad Masoud Rahimi Bidgoli, Nayebali Rezvani, Mehdi Sepehrnejad, Arash Shakibzadeh, Gholamreza Shariati, Noorossadat Seyyedi, Seyed MohammadSaleh Zahraei, Iman Safari, Elahe Elahi
Summary: The study identified different haplotypes and variants among COVID-19 infected individuals in Iran, with H1a and H1b haplotypes being the most prevalent, indicating a significant change in infection pattern over time. Additionally, a considerable proportion of samples were speculated to have recombinant genomes and co-infections, with co-existing viruses being related to those currently circulating in Iran.
Article
Genetics & Heredity
Rezvan Abtahi, Parvaneh Karimzadeh, Omid Aryani, Diba Akbarzadeh, Shadab Salehpour, Alireza Rezayi, Seyed Hassan Tonekaboni, Reza Zolfaghari Emameh, Massoud Houshmand
Summary: In this study, genetic analysis was performed on Iranian patients with Niemann-Pick disease type C (NPC), resulting in the identification of 10 novel mutations and determination of their pathogenicity. These findings will facilitate future prenatal diagnosis.
Article
Biochemistry & Molecular Biology
Mohammad A. Rezania, Azadeh Eghtedari, Masoumeh F. Taha, Ali M. Ardekani, Arash Javeri
Summary: Recent studies suggest that miR-302/367 cluster and aspirin can cooperate to induce reprogramming and tumor suppression in breast cancer cells. Aspirin enhances miR-302/367-induced reprogramming through upregulation of FOXD3 expression.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Genetics & Heredity
Parham Mardi, Bahareh Tavakoli-Far, Samira Sheibani Nia, Roshanak Jazayeri, Massoud Houshmand
Summary: This study aims to evaluate the frequency of three clinically significant CYP2B6 polymorphisms in three major Iranian ethnicities. The results show that Kurds have a higher risk of adverse drug reactions and insufficient anti-HIV response compared to other Iranians.