The Eyes Absent proteins in development and disease

Dual-specificity phosphatases: critical regulators with diverse cellular targets

(2015) Kate I. Patterson et al.   BIOCHEMICAL JOURNAL

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

(2012) M. Ahmed et al.   DEVELOPMENT

Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination

(2012) Santiago A. Morillo et al.   DEVELOPMENTAL BIOLOGY

Eya1-Six1 Interaction Is Sufficient to Induce Hair Cell Fate in the Cochlea by Activating Atoh1 Expression in Cooperation with Sox2

(2012) Mohi Ahmed et al.   DEVELOPMENTAL CELL

SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer

(2012) Chu-An Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The EYA Tyrosine Phosphatase Activity Is Pro-Angiogenic and Is Inhibited by Benzbromarone

(2012) Emmanuel Tadjuidje et al.   PLoS One

Epigenomic Analysis of Aberrantly Methylated Genes in Colorectal Cancer Identifies Genes Commonly Affected by Epigenetic Alterations

(2011) Young-Ho Kim et al.   ANNALS OF SURGICAL ONCOLOGY

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

Classification of Epstein-Barr Virus-Positive Gastric Cancers by Definition of DNA Methylation Epigenotypes

(2011) K. Matsusaka et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Structure-Based Virtual Screening Approach to the Discovery of Novel Inhibitors of Eyes Absent 2 Phosphatase with Various Metal Chelating Moieties

(2011) Hwangseo Park et al.   Chemical Biology & Drug Design

Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium

(2011) Ahmed HK El-Hashash et al.   DEVELOPMENT

Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

(2011) Xuguang Nie et al.   DEVELOPMENTAL BIOLOGY

Characterization of the threonine-phosphatase of mouse eyes absent 3

(2011) Teruyuki Sano et al.   FEBS LETTERS

Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy

(2011) Seung Hee Lee et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Circadian Cycles of Gene Expression in the Coral, Acropora millepora

(2011) Aisling K. Brady et al.   PLoS One

Association between Genetic Subgroups of Pancreatic Ductal Adenocarcinoma Defined by High Density 500 K SNP-Arrays and Tumor Histopathology

(2011) María Laura Gutiérrez et al.   PLoS One

Altered expression of DACH1 and cyclin D1 in endometrial cancer

(2010) Fangfang Nan et al.   CANCER BIOLOGY & THERAPY

H2AX post-translational modifications in the ionizing radiation response and homologous recombination

(2010) Anyong Xie et al.   CELL CYCLE

Identification of Eya3 and TAC1 as Long-Day Signals in the Sheep Pituitary

(2010) Sandrine M. Dupré et al.   CURRENT BIOLOGY

Acute Induction of Eya3 by Late-Night Light Stimulation Triggers TSHβ Expression in Photoperiodism

(2010) Koh-hei Masumoto et al.   CURRENT BIOLOGY

A Molecular Switch for Photoperiod Responsiveness in Mammals

(2010) Hugues Dardente et al.   CURRENT BIOLOGY

Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR

(2010) Shigeru Sato et al.   DEVELOPMENTAL BIOLOGY

Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung

(2010) Ahmed H.K. El-Hashash et al.   DEVELOPMENTAL BIOLOGY

Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors

(2010) Karen M. Neilson et al.   DEVELOPMENTAL DYNAMICS

Transcription Elongation Regulator 1 Is a Co-integrator of the Cell Fate Determination Factor Dachshund Homolog 1

(2010) Jie Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sipl1 and Rbck1 Are Novel Eya1-Binding Proteins with a Role in Craniofacial Development

(2010) K. Landgraf et al.   MOLECULAR AND CELLULAR BIOLOGY

The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration and invasion of tumor cells

(2010) R N Pandey et al.   ONCOGENE

Attenuation of Forkhead signaling by the retinal determination factor DACH1

(2010) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans

(2010) T. Hirose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis

(2009) Youe Li et al.   BIOLOGY OF THE CELL

Loss of Heterozygosity at 2q37 in Sporadic Wilms' Tumor: Putative Role for miR-562

(2009) K. M. Drake et al.   CLINICAL CANCER RESEARCH

Interactions with the Abelson Tyrosine Kinase Reveal Compartmentalization of Eyes Absent Function between Nucleus and Cytoplasm

(2009) Wenjun Xiong et al.   DEVELOPMENTAL CELL

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor

(2009) Suk-Kyeong Jung et al.   FASEB JOURNAL

Dephosphorylation of the C-terminal Tyrosyl Residue of the DNA Damage-related Histone H2A.X Is Mediated by the Protein Phosphatase Eyes Absent

(2009) Navasona Krishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and Functional Characterization of SixSIX1Branchio-oto-renal Syndrome Mutations

(2009) Aaron N. Patrick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus

(2009) Hao Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling

(2009) Seung Hee Lee et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

Histone H2AX is integral to hypoxia-driven neovascularization

(2009) Matina Economopoulou et al.   NATURE MEDICINE

Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis

(2009) S J Miller et al.   ONCOGENE

The Dachshund gene in development and hormone-responsive tumorigenesis

(2009) Vladimir M. Popov et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Innate Immune Cells Cast an Eye on DNA

(2009) L. E. Sander et al.   Journal of Molecular Cell Biology

Evolution of protein phosphatases in plants and animals

(2008) Greg B. G. Moorhead et al.   BIOCHEMICAL JOURNAL

DNA-Binding and Regulation Mechanisms of the SIX Family of Retinal Determination Proteins†

(2008) Shengyong Hu et al.   BIOCHEMISTRY

Pleiotropic effects in Eya3 knockout mice

(2008) Torben Söker et al.   BMC DEVELOPMENTAL BIOLOGY

Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion

(2008) Gerhard Schlosser et al.   DEVELOPMENTAL BIOLOGY

Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease

(2008) Rafael Pulido et al.   FEBS Journal

Differential expression of Eya1 and Eya2 during chick early embryonic development

(2008) Tadashi Ishihara et al.   GENE EXPRESSION PATTERNS

Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear

(2008) D. Zou et al.   HUMAN MOLECULAR GENETICS

Overexpression of DNA repair genes is associated with metastasis: A new hypothesis

(2008) A SARASIN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

(2008) Andrew Xiao et al.   NATURE

Thyrotrophin in the pars tuberalis triggers photoperiodic response

(2008) Nobuhiro Nakao et al.   NATURE

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

(2008) J. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8

(2008) K. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA