Structure-function analyses of the human SIX1–EYA2 complex reveal insights into metastasis and BOR syndrome

SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer

(2012) Chu-An Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis

(2012) Paul Delgado-Olguín et al.   NATURE GENETICS

Discovery, optimization and validation of an optimal DNA-binding sequence for the Six1 homeodomain transcription factor

(2012) Yubing Liu et al.   NUCLEIC ACIDS RESEARCH

SIX1 promotes epithelial–mesenchymal transition in colorectal cancer through ZEB1 activation

(2012) H Ono et al.   ONCOGENE

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome

(2011) Q.-f. Wang et al.   BLOOD

Upregulation of Notch2 and Six1 Is Associated with Progression of Early-Stage Lung Adenocarcinoma and a More Aggressive Phenotype at Advanced Stages

(2011) T. Mimae et al.   CLINICAL CANCER RESEARCH

The Phenix software for automated determination of macromolecular structures

(2011) Paul D. Adams et al.   METHODS

SDM--a server for predicting effects of mutations on protein stability and malfunction

(2011) C. L. Worth et al.   NUCLEIC ACIDS RESEARCH

Experimental phasing withSHELXC/D/E: combining chain tracing with density modification

(2010) George M. Sheldrick   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mutation screening of the EYA1, SIX1, and SIX5 genes in a large cohort of patients harboring branchio-oto-renal syndrome calls into question the pathogenic role of SIX5 mutations

(2010) Pauline Krug et al.   HUMAN MUTATION

Human Telomerase RNA Gene Amplification Detection Increases the Specificity of Cervical Intraepithelial Neoplasia Screening

(2010) Lei Zheng et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration and invasion of tumor cells

(2010) R N Pandey et al.   ONCOGENE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor

(2009) Suk-Kyeong Jung et al.   FASEB JOURNAL

Biochemical and Functional Characterization of SixSIX1Branchio-oto-renal Syndrome Mutations

(2009) Aaron N. Patrick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition

(2009) Erica L. McCoy et al.   JOURNAL OF CLINICAL INVESTIGATION

The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling

(2009) Douglas S. Micalizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis

(2009) S J Miller et al.   ONCOGENE

DNA-Binding and Regulation Mechanisms of the SIX Family of Retinal Determination Proteins†

(2008) Shengyong Hu et al.   BIOCHEMISTRY

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Branchio-oto-renal syndrome (BOR): novel mutations in theEYA1gene, and a review of the mutational genetics of BOR

(2008) Dana J. Orten et al.   HUMAN MUTATION