High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation

HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium

(2017) Mario Ruiz et al.   Lipids in Health and Disease

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

(2017) Sarah E. Heywood et al.   Science Translational Medicine

High-Density Lipoprotein–Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1Highlights

(2016) Mario Ruiz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

RVX-208, a BET-inhibitor for treating atherosclerotic cardiovascular disease, raises ApoA-I/HDL and represses pathways that contribute to cardiovascular disease

(2016) Dean Gilham et al.   ATHEROSCLEROSIS

High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I

(2016) Joanne T.M. Tan et al.   DIABETES

The role of high-density lipoproteins in the regulation of angiogenesis

(2015) Joanne T.M. Tan et al.   CARDIOVASCULAR RESEARCH

Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach

(2015) Kapil Gadkar et al.   JOURNAL OF LIPID RESEARCH

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Novel concepts in HDL pharmacology

(2014) A. T. Remaley et al.   CARDIOVASCULAR RESEARCH

High-density lipoproteins as modulators of endothelial cell functions: alterations in patients with coronary artery disease

(2014) A. Kratzer et al.   CARDIOVASCULAR RESEARCH

HDL-mediated mechanisms of protection in cardiovascular disease

(2014) A. Kontush   CARDIOVASCULAR RESEARCH

The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment

(2014) Qiao Cheng et al.   Cellular & Molecular Immunology

High-Density Lipoprotein

(2014) Thomas F. Lüscher et al.   CIRCULATION RESEARCH

High-Density Lipoproteins in the Prevention of Cardiovascular Disease: Changing the Paradigm

(2014) S Tuteja et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Beginning to Understand High-Density Lipoproteins

(2014) Carlos G. Santos-Gallego et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking

(2013) Fengyan Jin et al.   ANGIOGENESIS

Hyperlipidemia Attenuates Vascular Endothelial Growth Factor–Induced Angiogenesis, Impairs Cerebral Blood Flow, and Disturbs Stroke Recovery via Decreased Pericyte Coverage of Brain Endothelial Cells

(2013) Anil Zechariah et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HDL and endothelial protection

(2013) A Tran-Dinh et al.   BRITISH JOURNAL OF PHARMACOLOGY

SDF-1 restores angiogenesis synergistically with VEGF upon LDL exposure despite CXCR4 internalization and degradation

(2013) Fengyan Jin et al.   CARDIOVASCULAR RESEARCH

Multifunctional regulation of angiogenesis by high-density lipoproteins

(2013) Hamish C.G. Prosser et al.   CARDIOVASCULAR RESEARCH

HDL and endothelial protection: examining evidence from HDL inherited disorders

(2013) Monica Gomaraschi et al.   Clinical Lipidology

High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α

(2013) Joanne T. M. Tan et al.   FASEB JOURNAL

An involvement of SR-B1 mediated PI3K–Akt–eNOS signaling in HDL-induced cyclooxygenase 2 expression and prostacyclin production in endothelial cells

(2012) Qing-Hai Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine kinase and sphingosine 1-phosphate in the heart: A decade of progress

(2012) Joel S. Karliner   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

(2012) Konstantin Gaengel et al.   DEVELOPMENTAL CELL

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

(2012) Bongnam Jung et al.   DEVELOPMENTAL CELL

Sphingosine kinase inhibition exerts both pro- and anti-atherogenic effects in low-density lipoprotein receptor-deficient (LDL-R−/−) mice

(2012) Francesco Potì et al.   THROMBOSIS AND HAEMOSTASIS

Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins

(2008) A. R. Tall   JOURNAL OF INTERNAL MEDICINE

Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: Effect of simvastatin

(2008) María González-Díez et al.   THROMBOSIS AND HAEMOSTASIS