HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium

High-Density Lipoprotein–Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1Highlights

(2016) Mario Ruiz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sphingosine-1-phosphate reduces ischaemia–reperfusion injury by phosphorylating the gap junction protein Connexin43

(2016) Sandrine Morel et al.   CARDIOVASCULAR RESEARCH

Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages

(2016) Yumei Zhang et al.   PLoS One

Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation

(2015) Cecilia Frej et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The miR-573/apoM/Bcl2A1-dependent signal transduction pathway is essential for hepatocyte apoptosis and hepatocarcinogenesis

(2015) Yan-Wei Hu et al.   APOPTOSIS

Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL

(2015) Iryna Sutter et al.   ATHEROSCLEROSIS

Uncleaved ApoM Signal Peptide Is Required for Formation of Large ApoM/Sphingosine 1-Phosphate (S1P)-enriched HDL Particles

(2015) Mingxia Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Scavenger Receptor BI and High-Density Lipoprotein Regulate Thymocyte Apoptosis in Sepsis

(2014) Ling Guo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sphingosine 1-phosphate has anti-apoptotic effect on liver sinusoidal endothelial cells and proliferative effect on hepatocytes in a paracrine manner in human

(2014) Takeshi Nowatari et al.   HEPATOLOGY RESEARCH

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

HDL and endothelial protection

(2013) A Tran-Dinh et al.   BRITISH JOURNAL OF PHARMACOLOGY

High density lipoproteins and endothelial functions: mechanistic insights and alterations in cardiovascular disease

(2013) Meliana Riwanto et al.   JOURNAL OF LIPID RESEARCH

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

(2013) C Rutherford et al.   Cell Death & Disease

Sphingosine 1-Phosphate (S1P) Carrier-dependent Regulation of Endothelial Barrier

(2012) Brent A. Wilkerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipopolysaccharide and Sphingosine-1-Phosphate Cooperate To Induce Inflammatory Molecules and Leukocyte Adhesion in Endothelial Cells

(2012) I. Fernandez-Pisonero et al.   JOURNAL OF IMMUNOLOGY

Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P3

(2012) Elisabeth I. Schmitz et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Deletion of RBP-J in dendritic cells compromises TLR-mediated DC activation accompanied by abnormal cytoskeleton reorganization

(2012) Yun-Ru Chen et al.   MOLECULAR BIOLOGY REPORTS

Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

(2011) Sara Elsøe et al.   ATHEROSCLEROSIS

Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems

(2011) Raquel Bajo-Grañeras et al.   GLIA

Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase

(2011) Ko Fujimori et al.   JOURNAL OF NEUROCHEMISTRY

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

(2011) C. Christoffersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Stimulation of Cell Surface F 1 -ATPase Activity by Apolipoprotein A-I Inhibits Endothelial Cell Apoptosis and Promotes Proliferation

(2009) Claudia Radojkovic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proteomic Analysis of Defined HDL Subpopulations Reveals Particle-Specific Protein Clusters

(2009) W. Sean Davidson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apolipoprotein M predicts pre-β-HDL formation: studies in type 2 diabetic and nondiabetic subjects

(2009) P. Plomgaard et al.   JOURNAL OF INTERNAL MEDICINE

Serendipitous Fatty Acid Binding Reveals the Structural Determinants for Ligand Recognition in Apolipoprotein M

(2009) Madhumati Sevvana et al.   JOURNAL OF MOLECULAR BIOLOGY

Sphingosine 1-phosphate attenuates H2O2-induced apoptosis in endothelial cells

(2008) Tetsuya Moriue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Signal Peptide Anchors Apolipoprotein M in Plasma Lipoproteins and Prevents Rapid Clearance of Apolipoprotein M from Plasma

(2008) Christina Christoffersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY