The failure of anxiolytic therapies in early clinical trials: what needs to be done
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Title
The failure of anxiolytic therapies in early clinical trials: what needs to be done
Authors
Keywords
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Journal
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume 24, Issue 4, Pages 543-556
Publisher
Informa Healthcare
Online
2015-03-02
DOI
10.1517/13543784.2015.1019063
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- (2015) Allan V. Kalueff et al. BEHAVIOURAL BRAIN RESEARCH
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- (2014) Allan V. Kalueff et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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- (2013) Michael Nguyen et al. BEHAVIOURAL BRAIN RESEARCH
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- (2013) S Hong Lee et al. NATURE GENETICS
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- (2013) Georg Stoll et al. NATURE NEUROSCIENCE
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- (2013) Adam Michael Stewart et al. NEUROCHEMISTRY INTERNATIONAL
- Mouse Phenome Database
- (2013) Stephen C. Grubb et al. NUCLEIC ACIDS RESEARCH
- Developing zebrafish models of autism spectrum disorder (ASD)
- (2013) Adam Michael Stewart et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
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- (2013) George A. Lemieux et al. PLOS BIOLOGY
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- (2012) Kay M. Tye et al. NATURE REVIEWS NEUROSCIENCE
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- (2012) Ehud Fonio et al. PLoS One
- Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology
- (2012) David Kokel et al. TRENDS IN BIOTECHNOLOGY
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- (2011) Joseph Loscalzo et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
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