Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
David Hernandez-Silva, Francisca Alcaraz-Perez, Horacio Perez-Sanchez, Maria Luisa Cayuela
Summary: Virtual Screening (VS) techniques combined with in vivo screening in the zebrafish model are used in drug development for faster and more efficient results. This review discusses different VS techniques, the use of zebrafish as a vertebrate model for drug discovery, and the benefits of combining these approaches.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Article
Environmental Sciences
Agnieszka Gajewicz-Skretna, Maciej Gromelski, Ewelina Wyrzykowska, Ayako Furuhama, Hiroshi Yamamoto, Noriyuki Suzuki
Summary: The study demonstrates that key factors driving acute aquatic toxicity include lipophilicity, electrophilic reactivity, molecular polarizability, and size. Local models, trained on homogeneous data sets, show less errors and are superior to the global models. Despite worse performance metrics, global models have a wider applicability domain, making them more useful in practical regulatory applications.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Pharmacology & Pharmacy
Rashid Giniatullin
Summary: 5-hydroxytryptamine (5-HT) is considered a key mediator in migraine, but the role of 5-HT3 receptors in pain transmission remains controversial. The applicability of currently available 5-HT3 antagonists in migraine treatment is not clearly supported by clinical data.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Minjie Wan, Zhanchuan Ma, Jiawen Han, Min Rao, Feng Hu, Pujun Gao, Xiaocong Wang
Summary: The 5-HT/5-HT7R signaling pathway helps to constrain inflammation through functional Bregs in ulcerative colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Joanna Miklosz, Bartlomiej Kalaska, Piotr Podlasz, Malgorzata Chmielewska-Krzesinska, Milosz Zajaczkowski, Adam Kosinski, Dariusz Pawlak, Andrzej Mogielnicki
Summary: The research found that protamine sulfate (PS) can cause cardiovascular and respiratory abnormalities in zebrafish and rats, but not signs of heart damage in mice. The cardiorespiratory toxicity of PS appears to be charge-dependent and involves enhanced release of nitric oxide.
Article
Psychiatry
Jan Terock, Antoine Weihs, Alexander Teumer, Johanna Klinger-Koenig, Deborah Janowitz, Hans J. Grabe
Summary: Previous studies have suggested a connection between childhood trauma, serotonergic neurotransmission, and alexithymia. The study found that childhood trauma and the rs6295 polymorphism have a significant interaction effect on alexithymia in male subjects.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Kate Beecher, Joshua Wang, Fatemeh Chehrehasa, Ronan Depoortere, Mark A. Varney, Adrian Newman-Tancredi, Selena E. Bartlett, Arnauld Belmer
Summary: The consumption of high-sugar food has been linked to the increase in obesity prevalence. A recent study found that chronic sucrose consumption can alter the serotonergic neuroplasticity in the neural circuits involved in feeding control. Specifically, the 5-HT1A receptor subtype plays a role in the regulation of mood, anxiety, and appetite, and may be involved in reversing addiction to substances of abuse. Targeting the 5-HT1A autoreceptors could be an effective therapeutic strategy to combat obesity resulting from overconsumption of high-sugar diet.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Anoosha Attaran, Arash Salahinejad, Mohammad Naderi, Adam L. Crane, Douglas P. Chivers, Som Niyogi
Summary: The study found that maternal exposure to high levels of Se-Met had significant transgenerational effects on the social behavior and cognition of zebrafish offspring, including increased stress, weakened group preferences, and impaired social learning in the exposed descendants. These effects were associated with dysregulation of the serotonergic system due to changes in mRNA expression of serotonin receptors, transporter, and monoamine oxidase.
ENVIRONMENTAL POLLUTION
(2021)
Article
Behavioral Sciences
Savita Kumari, Poonam Dhiman, Rajneesh Kumar, Shubham Nilkanth Rahmatkar, Damanpreet Singh
Summary: Zebrafish have become an important animal model for screening potential antiepileptic molecules in epilepsy research. This study developed a chronic zebrafish model of epilepsy and investigated the effect of PTZ kindling on cognitive functions. The findings showed that PTZ kindling caused spatial cognition deficits and reduced social exploration in zebrafish.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Engineering, Environmental
Gongqing Dong, Nan Wang, Ting Xu, Jingyu Liang, Ruxia Qiao, Daqiang Yin, Sijie Lin
Summary: Toxicology studies rely on morphometric analysis to detect abnormalities. A deep learning-based morphometric analysis (DLMA) has been proposed to identify abnormal phenotypes and vital organ features of zebrafish larvae. A data set of 2532 images was generated from toxicity screening of three categories of chemicals, and deep learning models were trained to achieve accurate analysis.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Li Wang, Yang Chen
Summary: In this study, a dual-emissive europium-copper cluster was designed and synthesized for the catalysis and sensing of serotonin (5-HT). This clusterzyme was found to be highly tyrosinase-active and ultra-sensitive for 5-HT, enabling the detection of 5-HT as low as 0.5 nM. It exhibited outstanding specificity even in the presence of similar neurotransmitters. The clusterzyme could catalyze the oxidation of 5-HT to generate a neurotoxic product, providing a potential alternative to natural enzymes and chromogenic agents in enzyme-based assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Liping Fang, Shan He, Peng Yin, Ning Wang, Bin Zhang, Haixiao Jin
Summary: This study presents the design, synthesis, and evaluation of a series of novel tryptamine derivatives with 5-HT 1B R activation. Several compounds were identified as more potent 5-HT 1B R activators compared to the FDA-approved drug sumatriptan. The molecular docking results provided insights into the binding mode and interactions between the compounds and 5-HT 1B R.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Zoology
Huan Wang, Tian-Xiu Qiu, Jian-Fei Lu, Han-Wei Liu, Ling Hu, Lei Liu, Jiong Chen
Summary: Exposure to trifloxystrobin (TFS) can decrease the resistance of fish to viral infections, leading to significant increases in viral replication. TFS induces autophagy and suppresses the immune response through the mTOR-mediated pathway, potentially contributing to viral disease outbreaks in aquatic environments.
ZOOLOGICAL RESEARCH
(2021)
Article
Chemistry, Analytical
Xiaofeng Zhu, Congcong Du, Ali Mohsin, Qian Yin, Feng Xu, Zebo Liu, Zejian Wang, Yingping Zhuang, Ju Chu, Meijin Guo, Xiwei Tian
Summary: A highly efficient, accurate, noninvasive detection method for gentamicin was developed to provide timely feedback for high-throughput screening of high-yield strains. The random forest algorithm was found to have the highest prediction accuracy. A stable genetically high-yield strain was successfully screened out and the new data sets were updated in the model database to improve the learning ability of the DBTL cycle.
ANALYTICAL CHEMISTRY
(2022)
Review
Neurosciences
Barbara D. Fontana, Talise E. Muller, Madeleine Cleal, Murilo S. de Abreu, William H. J. Norton, Konstantin A. Demin, Tamara G. Amstislavskaya, Elena Petersen, Allan Kalueff, Matthew O. Parker, Denis B. Rosemberg
Summary: Social behavior plays a crucial role in maintaining health and wellbeing, while dysfunctional interactions pose risks for physical and psychiatric disorders. Despite extensive research on the effects of positive and negative social interactions, the underlying mechanisms remain unclear. Zebrafish, with well-characterized social behavior phenotypes and genetic similarities to humans, offer a promising model for studying the fundamental mechanisms of social interactions.
PROGRESS IN NEUROBIOLOGY
(2022)
Review
Neurosciences
Fabiano Costa, Luiz Rosa, Vanessa A. Quadros, Murilo S. de Abreu, Adair R. S. Santos, Lynne U. Sneddon, Allan Kalueff, Denis B. Rosemberg
Summary: This article introduces the advantages of zebrafish as a pain model and its applications in studying the mechanisms of pain response. The article also discusses the latest research advances and outlines the potential advantages and limitations of zebrafish models in studying pain behaviors and mood disorders, as well as facilitating analgesic therapy screening.
CURRENT NEUROPHARMACOLOGY
(2022)
Review
Neurosciences
Murilo S. de Abreu, Fabiano Costa, Ana C. V. V. Giacomini, Konstantin A. Demin, Elena Petersen, Denis B. Rosemberg, Allan Kalueff
Summary: Although traditional medicine has been practiced for a long time, its therapeutic mechanisms are not fully understood. This study highlights the importance of using zebrafish as a model organism to study the neurotropic effects of traditional medicine and their potential in treating brain disorders.
CURRENT NEUROPHARMACOLOGY
(2022)
Review
Clinical Neurology
Murilo S. de Abreu, Fabiano Costa, Ana C. V. V. Giacomini, Konstantin A. Demin, Konstantin N. Zabegalov, Gleb O. Maslov, Yuriy M. Kositsyn, Elena Petersen, Tatiana Strekalova, Denis B. Rosemberg, Allan Kalueff
Summary: Mood disorders, particularly depression, are a leading cause of disability in humans. Anhedonia, the loss of pleasure, is a common and severe symptom of clinical depression. Experimental animal models are used extensively to understand the mechanisms of depression and develop new treatments, with rodents being widely validated. Zebrafish, as a model organism, is emerging as a powerful tool for studying affective disorders and modeling anhedonia, offering potential for translational research.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Letter
Veterinary Sciences
Murilo S. de Abreu, Ana C. V. V. Giacomini, Konstantin A. Demin, Elena V. Petersen, Allan V. Kalueff
Article
Neurosciences
Murilo S. de Abreu, Ana C. V. V. Giacomini, Rafael Genario, Konstantin A. Demin, Tamara G. Amstislavskaya, Fabiano Costa, Denis B. Rosemberg, Lynne U. Sneddon, Tatyana Strekalova, Marta C. Soares, Allan Kalueff
Summary: Pain is critical for organismal survival, evoking strong physiological and behavioral responses in various species. However, the long-term effects of early-life pain exposure on human and animal emotional responses remain poorly understood, indicating a need for further research in this area.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Leticia Marcon, Ana C. V. V. Giacomini, Bruna E. dos Santos, Fabiano Costa, Denis B. Rosemberg, Konstantin A. Demin, Allan V. Kalueff, Murilo S. de Abreu
Summary: Sex is an important variable in translational biomedical research, and there may be sex differences in zebrafish behavioral responses to pain and fear stimuli.
NEUROSCIENCE LETTERS
(2022)
Article
Cell Biology
Evgeniy Svirin, Ekaterina Veniaminova, Joao Pedro Costa-Nunes, Anna Gorlova, Aleksei Umriukhin, Allan Kalueff, Andrey Proshin, Daniel C. Anthony, Andrey Nedorubov, Anna Chung Kwan Tse, Susanne Walitza, Lee Wei Lim, Klaus-Peter Lesch, Tatyana Strekalova
Summary: The interaction between brain serotonin deficiency and environmental adversity leads to excessive aggression in females. Complete inactivation of the gene encoding tryptophan hydroxylase-2 results in the absence of neuronal serotonin synthesis and aggression in male and female mice. Moderate reduction in brain serotonin levels and exposure to stress also lead to increased aggression in male mice. Furthermore, changes in gene expression and myelination-related processes may underlie the molecular mechanisms of aggressive behavior.
Article
Pharmacology & Pharmacy
Maria A. Tikhonova, Nikolai A. Maslov, Alim A. Bashirzade, Eugenyi V. Nehoroshev, Vladislav Y. Babchenko, Nadezhda D. Chizhova, Elena O. Tsibulskaya, Anna A. Akopyan, Evgeniya V. Markova, Yi-Ling Yang, Kwok-Tung Lu, Allan V. Kalueff, Lyubomir I. Aftanas, Tamara G. Amstislavskaya
Summary: Researchers developed a laser-induced brain injury model in zebrafish, which successfully replicated behavioral and neuroanatomical changes observed in traumatic brain injury (TBI). The model showed similarities to mammalian TBI models, validating its effectiveness. The study also examined the changes in neurons and brain-derived neurotrophic factor (BDNF) after the injury, as well as the activation of microglia and the levels of hypoxia-inducible factor 1-alpha (Hif1a).
Review
Biochemistry & Molecular Biology
Evgeniy Svirin, Johannes de Munter, Aleksei Umriukhin, Elisaveta Sheveleva, Allan Kalueff, Andrei Svistunov, Sergey Morozov, Susanne Walitza, Tatyana Strekalova
Summary: Gangliosides play important roles in neural development and function, and their dysfunction is associated with neurological disorders and psychiatric conditions. Abnormal ganglioside function can result in neuroinflammation, aberrant myelination, and altered insulin receptor signaling. Understanding the role of gangliosides in developmental neuropsychiatric disorders is of great clinical significance.
Review
Biochemistry & Molecular Biology
Tatiana O. Kolesnikova, Konstantin A. Demin, Fabiano Costa, Konstantin N. Zabegalov, Murilo S. de Abreu, Elena Gerasimova, Allan Kalueff
Summary: Channelopathies are systemic disorders associated with dysfunctional ion channels. The zebrafish has become a popular model organism for studying these disorders, but there are still challenges to overcome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ilya S. Zhukov, Inessa Karpova, Nataliya A. Krotova, Ilya Y. Tissen, Konstantin A. Demin, Petr D. Shabanov, Evgeny A. Budygin, Allan Kalueff, Raul R. Gainetdinov
Summary: The study characterizes the behavioral and neurochemical phenotypes of TAAR1 knockout mice, finding that these mice exhibit increased aggression in the resident-intruder test, reduced self-grooming behavior in the novelty-induced grooming test, and higher cortical serotonin levels. The findings suggest a potential association between TAAR1 and aggression-related neuropsychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Fabiano V. Costa, Tatiana O. Kolesnikova, David S. Galstyan, Nikita P. Ilyin, Murilo S. de Abreu, Elena V. Petersen, Konstantin A. Demin, Konstantin B. Yenkoyan, Allan V. Kalueff
Summary: Psychiatric disorders are prevalent brain pathologies. Reliable animal models are needed for effective treatment. Zebrafish show complex behaviors similar to rodents and humans, making them suitable for modeling psychiatric disorders. However, there are challenges and the field needs further discussion and consideration of clinical prevalence and pathological complexity. Recent developments in molecular biology might pave the way for wider use of zebrafish in CNS disease modeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anton D. D. Shevlyakov, Tatiana O. O. Kolesnikova, Murilo S. S. de Abreu, Elena V. V. Petersen, Konstantin B. B. Yenkoyan, Konstantin A. A. Demin, Allan V. V. Kalueff
Summary: Epilepsy is a neurological disorder characterized by seizures and neuronal hyperactivity. The exact pathogenesis is not fully understood, but genetic factors are known to play a key role. In this study, a computational approach was used to generate a comprehensive network of molecular pathways associated with epilepsy. The study identified potential key interactors and revealed functional molecular pathways, highlighting the importance of targeting downstream pathways for more effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Veterinary Sciences
Maria M. Kotova, David S. Galstyan, Tatiana O. Kolesnikova, Murilo S. de Abreu, Tamara G. Amstislavskaya, Tatyana Strekalova, Elena V. Petersen, Konstantin B. Yenkoyan, Konstantin A. Demin, Allan V. Kalueff
Summary: Antimicrobial drugs can influence the central nervous system and gut microbiota, leading to changes in brain and behavior. Zebrafish models are useful for studying the effects of these drugs on the central nervous system. Recent research has revealed the impacts of a wide range of antimicrobial drugs on brain and behavior in zebrafish.
VETERINARY SCIENCES
(2023)