Multipronged approach for engineering novel peptide analogues of existing lantibiotics

Biosynthesis and Transport of the Lantibiotic Mutacin 1140 Produced by Streptococcus mutans

(2015) Jerome Escano et al.   JOURNAL OF BACTERIOLOGY

Product Formation by the Promiscuous Lanthipeptide Synthetase ProcM is under Kinetic Control

(2015) Yi Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In VivoPharmacokinetics and Pharmacodynamics of the Lantibiotic NAI-107 in a Neutropenic Murine Thigh Infection Model

(2014) Alexander J. Lepak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment

(2014) Jack C. Slootweg et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Price To Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases ProcM and HalM2

(2014) Christopher J. Thibodeaux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

(2014) Manuel A. Ortega et al.   NATURE

Cloning and Optimization of a Nisin Biosynthesis Pathway for Bacteriocin Harvest

(2014) Wentao Kong et al.   ACS Synthetic Biology

Site-Directed Mutations in the Lanthipeptide Mutacin 1140

(2013) Shaorong Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synthesis, Antimicrobial Activity, and Membrane Permeabilizing Properties of C-Terminally Modified Nisin Conjugates Accessed by CuAAC

(2013) Jack C. Slootweg et al.   BIOCONJUGATE CHEMISTRY

Heterologous Expression and Engineering Studies of Labyrinthopeptins, Class III Lantibiotics from Actinomadura namibiensis

(2013) Joanna M. Krawczyk et al.   CHEMISTRY & BIOLOGY

Chemical Synthesis of the Lantibiotic Lacticin 481 Reveals the Importance of Lanthionine Stereochemistry

(2013) Patrick J. Knerr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Saturation Mutagenesis of Lysine 12 Leads to the Identification of Derivatives of Nisin A with Enhanced Antimicrobial Activity

(2013) Evelyn M. Molloy et al.   PLoS One

Intensive Mutagenesis of the Nisin Hinge Leads to the Rational Design of Enhanced Derivatives

(2013) Brian Healy et al.   PLoS One

In vitro activity of the nisin dehydratase NisB

(2013) N. Garg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba

(2013) E. J. Sherwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Saturation mutagenesis of selected residues of the α-peptide of the lantibiotic lacticin 3147 yields a derivative with enhanced antimicrobial activity

(2013) Des Field et al.   Microbial Biotechnology

Generation of an actagardine A variant library through saturation mutagenesis

(2012) Steven Boakes et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli

(2012) Yanxiang Shi et al.   CHEMICAL COMMUNICATIONS

Developing oral probiotics fromStreptococcus salivarius

(2012) Philip A Wescombe et al.   Future Microbiology

Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010

(2012) Dawn M. Sievert et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Evaluation of NVB302 versus vancomycin activity in an in vitro human gut model of Clostridium difficile infection

(2012) G. S. Crowther et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Chemical Synthesis and Biological Activity of Analogues of the Lantibiotic Epilancin 15X

(2012) Patrick J. Knerr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Synthesis of Active and Stable Diaminopimelate Analogues of the Lantibiotic Peptide Lactocin S

(2012) Avena C. Ross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Bioengineered Nisin A Derivatives with Enhanced Activity against Both Gram Positive and Gram Negative Pathogens

(2012) Des Field et al.   PLoS One

The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S

(2012) Shaun M. K. McKinnie et al.   MedChemComm

Efficacy of the New Lantibiotic NAI-107 in Experimental Infections Induced by Multidrug-Resistant Gram-Positive Pathogens

(2011) Daniela Jabés et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcription Analysis of a Lantibiotic Gene Cluster from Bifidobacterium longum DJO10A

(2011) Ju-Hoon Lee et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacterial Display and Screening of Posttranslationally Thioether-Stabilized Peptides

(2011) Tjibbe Bosma et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Heterologous Expression, Biosynthesis, and Mutagenesis of Type II Lantibiotics from Bacillus licheniformis in Escherichia coli

(2011) Tânia Caetano et al.   CHEMISTRY & BIOLOGY

Methodologies and Strategies for the Bioengineering of Lantibiotics

(2011) Jun-ichi Nagao et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Critical shortage of new antibiotics in development against multidrug-resistant bacteria—Time to react is now

(2011) Laura Freire-Moran et al.   DRUG RESISTANCE UPDATES

Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans

(2011) Auke Johan van Heel et al.   Expert Opinion on Drug Metabolism & Toxicology

Antibiotics in the clinical pipeline in 2011

(2011) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Homologues and Bioengineered Derivatives of LtnJ Vary in Ability to Form D-Alanine in the Lantibiotic Lacticin 3147

(2011) S. Suda et al.   JOURNAL OF BACTERIOLOGY

Solid Supported Chemical Syntheses of Both Components of the Lantibiotic Lacticin 3147

(2011) Wei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nine Post-translational Modifications during the Biosynthesis of Cinnamycin

(2011) Ayşe Ökesli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

(2011) Alethea B. Tabor   ORGANIC & BIOMOLECULAR CHEMISTRY

Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates

(2011) Sabesan Yoganathan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Expression of the Lantibiotic Mersacidin in Bacillus amyloliquefaciens FZB42

(2011) Anna Maria Herzner et al.   PLoS One

Microbial engineering of dehydro-amino acids and lanthionines in non-lantibiotic peptides

(2010) Gert N. Moll et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Antibiotic discovery in the twenty-first century: current trends and future perspectives

(2010) Stefano Donadio et al.   JOURNAL OF ANTIBIOTICS

Production of Lantipeptides inEscherichia coli

(2010) Yanxiang Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The dawning of a ‘Golden era’ in lantibiotic bioengineering

(2010) Des Field et al.   MOLECULAR MICROBIOLOGY

Optimization of the production of the lantibiotic mutacin 1140 in minimal media

(2010) Neeti Dahal et al.   PROCESS BIOCHEMISTRY

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

(2010) Yuki Goto et al.   PLOS BIOLOGY

Insights into the Mode of Action of the Two-Peptide Lantibiotic Haloduracin

(2009) Trent J. Oman et al.   ACS Chemical Biology

Investigation of the Substrate Specificity of Lacticin 481 Synthetase by Using Nonproteinogenic Amino Acids

(2009) Matthew R. Levengood et al.   CHEMBIOCHEM

Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin

(2009) Antony N. Appleyard et al.   CHEMISTRY & BIOLOGY

Hospital and Societal Costs of Antimicrobial‐Resistant Infections in a Chicago Teaching Hospital: Implications for Antibiotic Stewardship

(2009) Rebecca R. Roberts et al.   CLINICAL INFECTIOUS DISEASES

Lantibiotics: Mode of Action, Biosynthesis and Bioengineering

(2009) G. Bierbaum et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Chemical Modification of the Carboxyl Terminal of Nisin A with Biotin does not Abolish Antimicrobial Activity Against the Indicator Organism, Kocuria rhizophila

(2009) Sam Maher et al.   International Journal of Peptide Research and Therapeutics

Synthesis and antibacterial activity of nisin-containing block copolymers

(2009) Pranav R. Joshi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Development of a high cell-density protocol for the production of pregallidermin, a non-toxic precursor of the lantibiotic gallidermin

(2009) Giovanni Medaglia et al.   JOURNAL OF BIOTECHNOLOGY

Pharmacokinetic and pharmacodynamic evaluation of the lantibiotic MU1140

(2009) Oliver Ghobrial et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids

(2009) Matthew R. Levengood et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase

(2009) Avena C. Ross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of essential and variable residues of nukacin ISK-1 by NNK scanning

(2009) Mohammad R. Islam et al.   MOLECULAR MICROBIOLOGY

Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system

(2009) Steven Boakes et al.   MOLECULAR MICROBIOLOGY

Synthesis and Biological Activity of Oxa-Lacticin A2, a Lantibiotic Analogue with Sulfur Replaced by Oxygen

(2009) Hongqiang Liu et al.   ORGANIC LETTERS

Solid-Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide Bis(desmethyl) Lacticin 3147 A2

(2008) Vijaya R. Pattabiraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidation of Lanthionines Renders the Lantibiotic Nisin Inactive

(2008) S. Wilson-Stanford et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Vancomycin−Nisin(1−12) Hybrid Restores Activity against Vancomycin Resistant Enterococci†

(2008) Christopher J. Arnusch et al.   BIOCHEMISTRY

Elucidation of the Antimicrobial Mechanism of Mutacin 1140

(2008) Leif Smith et al.   BIOCHEMISTRY

Use of lantibiotic synthetases for the preparation of bioactive constrained peptides

(2008) Matthew R. Levengood et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The lantibiotic mersacidin is a strong inducer of the cell wall stress response of Staphylococcus aureus

(2008) Peter Sass et al.   BMC MICROBIOLOGY

Therapeutic potential of type A (I) lantibiotics, a group of cationic peptide antibiotics

(2008) Leif Smith et al.   CURRENT OPINION IN MICROBIOLOGY

Pharmacodynamic activity of the lantibiotic MU1140

(2008) Oliver G. Ghobrial et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The generation of nisin variants with enhanced activity against specific Gram-positive pathogens

(2008) Des Field et al.   MOLECULAR MICROBIOLOGY