Streamlining drug synthesis

Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance May 20–21, 2014 Continuous Manufacturing Symposium

(2015) Ian R. Baxendale et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

(2015) Tetsu Tsubogo et al.   NATURE

A Three-Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous-Flow Processing

(2014) David R. Snead et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide

(2014) Claudio Battilocchio et al.   ORGANIC LETTERS

Process Intensification for the Continuous Flow Hydrogenation of Ethyl Nicotinate

(2014) Takashi Ouchi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Flow chemistry syntheses of natural products

(2013) Julio C. Pastre et al.   CHEMICAL SOCIETY REVIEWS

Sustainable Flow Oppenauer Oxidation of Secondary Benzylic Alcohols with a Heterogeneous Zirconia Catalyst

(2013) Rajeev Chorghade et al.   ORGANIC LETTERS

A Mild and Efficient Flow Procedure for the Transfer Hydrogenation of Ketones and Aldehydes using Hydrous Zirconia

(2013) Claudio Battilocchio et al.   ORGANIC LETTERS

A flow-based synthesis of Imatinib: the API of Gleevec

(2010) Mark D. Hopkin et al.   CHEMICAL COMMUNICATIONS