Engineering therapeutic T cells to suppress alloimmune responses using TCRs, CARs, or BARs

Generation of human islet-specific regulatory T cells by TCR gene transfer

(2017) Caroline M. Hull et al.   JOURNAL OF AUTOIMMUNITY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Therapeutic T cell engineering

(2017) Michel Sadelain et al.   NATURE

Increasing the safety and efficacy of chimeric antigen receptor T cell therapy

(2017) Hua Li et al.   Protein & Cell

Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision

(2017) Patrick R. Adair et al.   Frontiers in Immunology

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells

(2017) Nicholas A. J. Dawson et al.   Frontiers in Immunology

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII

(2016) Jeongheon Yoon et al.   BLOOD

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Immunosuppressive Drugs on Humoral Allosensitization after Kidney Transplant

(2016) O. Thaunat et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors

(2016) Hiroki Torikai et al.   MOLECULAR THERAPY

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

One-year Results of the Effects of Rituximab on Acute Antibody-Mediated Rejection in Renal Transplantation

(2016) Bénédicte Sautenet et al.   TRANSPLANTATION

How antigen specificity directs regulatory T-cell function: self, foreign and engineered specificity

(2016) R. E. Hoeppli et al.   HLA

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells

(2015) I. E. Dijke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Targeting indirect pathway CD4 T-cell alloresponses in the prevention of chronic transplant rejection

(2015) Jason Ali et al.   LANCET

Cell Therapy to Induce Allograft Tolerance: Time to Switch to Plan B?

(2015) Antoine Sicard et al.   Frontiers in Immunology

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

(2014) Y. C. Kim et al.   BLOOD

Chimeric Antigen Receptor T-cell Therapy to Target Hematologic Malignancies

(2014) S. S. Kenderian et al.   CANCER RESEARCH

Disappearance of T Cell-Mediated Rejection Despite Continued Antibody-Mediated Rejection in Late Kidney Transplant Recipients

(2014) P. F. Halloran et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells

(2014) Dan Blat et al.   MOLECULAR THERAPY

Prevention of Allogeneic Cardiac Graft Rejection by Transfer of Ex Vivo Expanded Antigen-Specific Regulatory T-Cells

(2014) Fumika Takasato et al.   PLoS One

Allorecognition Pathways in Transplant Rejection and Tolerance

(2013) Jason M. Ali et al.   TRANSPLANTATION

The Spleen Is the Major Source of Antidonor Antibody-Secreting Cells in Murine Heart Allograft Recipients

(2012) A. Sicard et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells

(2012) T. Kinnunen et al.   BLOOD

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

(2012) Moa Fransson et al.   Journal of Neuroinflammation

Understanding the Causes of Kidney Transplant Failure: The Dominant Role of Antibody-Mediated Rejection and Nonadherence

(2011) J. Sellarés et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Functional Regulatory T Cells Produced by Inhibiting Cyclic Nucleotide Phosphodiesterase Type 3 Prevent Allograft Rejection

(2011) G. Feng et al.   Science Translational Medicine

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Plasma cells negatively regulate the follicular helper T cell program

(2010) Nadége Pelletier et al.   NATURE IMMUNOLOGY

Direct versus Indirect Allorecognition Pathways: On the Right Track

(2009) G. Benichou et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

(2009) Graham P. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The importance of the indirect pathway of allorecognition in clinical transplantation

(2008) M Refik Gökmen et al.   CURRENT OPINION IN IMMUNOLOGY

Redirection of Regulatory T Cells With Predetermined Specificity for the Treatment of Experimental Colitis in Mice

(2008) Eran Elinav et al.   GASTROENTEROLOGY

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice

(2008) Julia Yuen-Shan Tsang et al.   JOURNAL OF CLINICAL INVESTIGATION