Biologics in Chronic Rhinosinusitis: An Update and Thoughts for Future Directions

Commonality of the IL-4/IL-13 pathway in atopic diseases

(2017) Namita A. Gandhi et al.   Expert Review of Clinical Immunology

Multicenter Study of a Novel Topical Interleukin-1 Receptor Inhibitor, Isunakinra, in Subjects With Moderate to Severe Dry Eye Disease

(2017) Michael H. Goldstein et al.   Eye & Contact Lens-Science and Clinical Practice

Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn’s Disease: A Phase 2a Study

(2017) Bruce E. Sands et al.   GASTROENTEROLOGY

Therapeutic pipeline for atopic dermatitis: End of the drought?

(2017) Amy S. Paller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tildrakizumab versus placebo or etanercept for chronic plaque psoriasis (reSURFACE 1 and reSURFACE 2): results from two randomised controlled, phase 3 trials

(2017) Kristian Reich et al.   LANCET

Tezepelumab in Adults with Uncontrolled Asthma

(2017) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risankizumab versus Ustekinumab for Moderate-to-Severe Plaque Psoriasis

(2017) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term “real-life” safety of omalizumab in patients with severe uncontrolled asthma: A nine-year study

(2017) Danilo Di Bona et al.   RESPIRATORY MEDICINE

Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti-Interferon-γ Antibody, in Patients With Discoid Lupus Erythematosus

(2017) Victoria P. Werth et al.   Arthritis & Rheumatology

Biotherapeutics in Chronic Rhinosinusitis with and without Nasal Polyps

(2017) Claus Bachert et al.   Journal of Allergy and Clinical Immunology-In Practice

A phase 3 randomized trial comparing inolimomab vs usual care in steroid-resistant acute GVHD

(2016) Gérard Socié et al.   BLOOD

Management of rhinosinusitis

(2016) Andrew J. Para et al.   Current Opinion in Allergy and Clinical Immunology

A revolutionary therapeutic approach for psoriasis: bispecific biological agents

(2016) T. Torres et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis

(2016) Claus Bachert et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

(2016) Peter Tomassen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A randomized trial of quilizumab in adults with refractory chronic spontaneous urticaria

(2016) Jeffrey M. Harris et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered Th17/Treg Ratio in Nasal Polyps With Distinct Cytokine Profile

(2016) Dawei Wu et al.   MEDICINE

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Treatment With Sirukumab (CNTO 136) in Patients With Active Lupus Nephritis

(2016) Brad H. Rovin et al.   Arthritis & Rheumatology

Secukinumab (AIN-457) for the treatment of Psoriasis

(2016) Tarannum Jaleel et al.   Expert Review of Clinical Pharmacology

Phenotypes and Emerging Endotypes of Chronic Rhinosinusitis

(2016) Claus Bachert et al.   Journal of Allergy and Clinical Immunology-In Practice

Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy

(2015) Susanne Radonjic-Hoesli et al.   Annual Review of Pharmacology and Toxicology

Targeting Th17 Effector Cytokines for the Treatment of Autoimmune Diseases

(2015) Tetsuya Yamagata et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Emerging biologics for the treatment of chronic rhinosinusitis

(2015) Bauke Pauwels et al.   Expert Review of Clinical Immunology

Medical Therapies for Adult Chronic Sinusitis

(2015) Luke Rudmik et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis

(2015) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second-generation Asians suggest genetic regulation of eosinophilia

(2015) Mahboobeh Mahdavinia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic rhinosinusitis pathogenesis

(2015) Whitney W. Stevens et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophilic esophagitis strongly linked to chronic rhinosinusitis

(2015) Reema Padia et al.   LARYNGOSCOPE

Cost of adult chronic rhinosinusitis: A systematic review

(2015) Kristine A. Smith et al.   LARYNGOSCOPE

Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β

(2015) Susan E Lacy et al.   mAbs

The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β

(2015) Jean-Michel Rondeau et al.   mAbs

A Phase 2 Trial of Guselkumab versus Adalimumab for Plaque Psoriasis

(2015) Kenneth B. Gordon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of omalizumab therapy on medication requirements for chronic rhinosinusitis

(2015) Rakesh K. Chandra et al.   International Forum of Allergy & Rhinology

Biologic Therapies Targeting Eosinophils: Current Status and Future Prospects

(2015) Fanny Legrand et al.   Journal of Allergy and Clinical Immunology-In Practice

Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects

(2014) J. P. Arm et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Anti-interleukin 4 and 13 for asthma treatment in the era of endotypes

(2014) Andrew L. Kau et al.   Current Opinion in Allergy and Clinical Immunology

Novel investigational biologics for the treatment of cancer cachexia

(2014) Joseph D Ma et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Biologic therapy in asthma: entering the new age of personalized medicine

(2014) Merritt L. Fajt et al.   JOURNAL OF ASTHMA

Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

(2014) Gail M. Gauvreau et al.   NEW ENGLAND JOURNAL OF MEDICINE

ICON: chronic rhinosinusitis

(2014) Claus Bachert et al.   World Allergy Organization Journal

Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial

(2013) Tom W J Huizinga et al.   ANNALS OF THE RHEUMATIC DISEASES

Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1  Antibody, in Patients With Type 2 Diabetes

(2013) J. Sloan-Lancaster et al.   DIABETES CARE

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

(2013) Michel Laviolette et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Correlations between Psoriasis and Inflammatory Bowel Diseases

(2013) Nevena Skroza et al.   Biomed Research International

Rituximab modulates the expression of IL-22 in the salivary glands of patients with primary Sjogren's syndrome

(2012) Francesco Ciccia et al.   ANNALS OF THE RHEUMATIC DISEASES

Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma

(2012) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge

(2011) H. Imaoka et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis

(2011) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Health state utility values in patients undergoing endoscopic sinus surgery

(2011) Zachary M. Soler et al.   LARYNGOSCOPE

XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1β-mediated diseases

(2011) Alexander M. Owyang et al.   mAbs

Chronic rhinosinusitis in the setting of other chronic inflammatory diseases

(2010) Rakesh K. Chandra et al.   AMERICAN JOURNAL OF OTOLARYNGOLOGY

Role of Thymic Stromal Lymphopoietin in the Pathogenesis of Nasal Polyposis

(2010) Tao Liu et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Ustekinumab

(2010) Oya Cingoz   mAbs

A Comprehensive Review of the Adverse Effects of Systemic Corticosteroids

(2010) David M. Poetker et al.   OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA

A High-Affinity Fully Human Anti-IL-6 mAb, 1339, for the Treatment of Multiple Myeloma

(2009) M. Fulciniti et al.   CLINICAL CANCER RESEARCH

Tocilizumab

(2009) Vicki Oldfield et al.   DRUGS

The significance of OX40 and OX40L to T-cell biology and immune disease

(2009) Michael Croft et al.   IMMUNOLOGICAL REVIEWS

Fontolizumab in moderate to severe Crohnʼs disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study

(2009) Walter Reinisch et al.   INFLAMMATORY BOWEL DISEASES

Anti-IgE (omalizumab): A new therapeutic approach for chronic rhinosinusitis

(2008) Sonja A. Grundmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY