Peptide hormone relaxin: from bench to bedside

Short-term (48 hours) intravenous serelaxin infusion has no effect on myogenic tone or vascular remodeling in rat mesenteric arteries

(2017) Maria Jelinic et al.   MICROCIRCULATION

Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial

(2017) Victoria K. Snowdon et al.   PLOS MEDICINE

Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes

(2017) Hooi Hooi Ng et al.   Scientific Reports

Serelaxin improves the pathophysiology of placental ischemia in the reduced uterine perfusion pressure rat model of preeclampsia

(2016) Jose A. Santiago-Font et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

9th Hatter Biannual Meeting: position document on ischaemia/reperfusion injury, conditioning and the ten commandments of cardioprotection

(2016) R. M. Bell et al.   BASIC RESEARCH IN CARDIOLOGY

Effects of relaxin on cardiac fibrosis, apoptosis, and tachyarrhythmia in rats with myocardial infarction

(2016) Deguo Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Vascular actions of relaxin: nitric oxide and beyond

(2016) C H Leo et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vitro fertilization success rates by patient occupation, income and educational level

(2016) J. Anderson et al.   FERTILITY AND STERILITY

Pre-eclampsia

(2016) Ben W J Mol et al.   LANCET

Does serelaxin treatment alter passive mechanical wall properties in small resistance arteries?

(2016) Maria Jelinic et al.   MICROCIRCULATION

Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation

(2016) Sarah A. Marshall et al.   Reproductive Biology and Endocrinology

Serelaxin: A Novel Therapeutic for Vascular Diseases

(2016) Chen Huei Leo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Recombinant human relaxin versus placebo for cervical ripening: a double-blind randomised trial in pregnant women scheduled for induction of labour

(2016) Gerson Weiss et al.   BMC Pregnancy and Childbirth

Reduced Uterine Perfusion Pressure (RUPP) Model of Preeclampsia in Mice

(2016) Tomofumi Fushima et al.   PLoS One

The Microenvironment of Human Implantation: Determinant of Reproductive Success

(2015) Lois A. Salamonsen et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Relaxin Peptide Hormones Are Protective During the Early Stages of Ischemic Stroke in Male Rats

(2015) Lindsay H. Bergeron et al.   ENDOCRINOLOGY

Relaxin protects cardiac muscle cells from hypoxia/reoxygenation injury: involvement of the Notch-1 pathway

(2015) Giulia Boccalini et al.   FASEB JOURNAL

Cardioprotective potential of annexin-A1 mimetics in myocardial infarction

(2015) Chengxue Qin et al.   PHARMACOLOGY & THERAPEUTICS

Therapeutic Effects of Serelaxin in Acute Heart Failure

(2014) Xiao-Jun Du et al.   CIRCULATION JOURNAL

Associations between Individual and Combined Polymorphisms of the TNF and VEGF Genes and the Embryo Implantation Rate in Patients Undergoing In Vitro Fertilization (IVF) Programs

(2014) Radia Boudjenah et al.   PLoS One

Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes

(2014) Jennifer L. Rojko et al.   TOXICOLOGIC PATHOLOGY

A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure

(2013) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

Treatment for cerebral small vessel disease: effect of relaxin on the function and structure of cerebral parenchymal arterioles during hypertension

(2013) Siu-Lung Chan et al.   FASEB JOURNAL

Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment

(2013) Maria Jelinic et al.   FASEB JOURNAL

Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury

(2013) Massimo Collino et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Renal Ischemia-Reperfusion Injury Amplifies the Humoral Immune Response

(2013) R. Fuquay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Relaxin decreases the severity of established hepatic fibrosis in mice

(2013) Robert G. Bennett et al.   LIVER INTERNATIONAL

Ischaemia-reperfusion injury: a major protagonist in kidney transplantation

(2013) C. Ponticelli   NEPHROLOGY DIALYSIS TRANSPLANTATION

Impaired effect of relaxin on vasoconstrictor reactivity in spontaneous hypertensive rats

(2013) Joris van Drongelen et al.   PEPTIDES

Relaxin Protects Rat Lungs from Ischemia-Reperfusion Injury via Inducible NO Synthase: Role of ERK-1/2, PI3K, and Forkhead Transcription Factor FKHRL1

(2013) Konstantin Alexiou et al.   PLoS One

A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model

(2012) Jing Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Anatomical, Physiological and Metabolic Changes with Gestational Age during Normal Pregnancy

(2012) Khaled Abduljalil et al.   CLINICAL PHARMACOKINETICS

Effect of Serelaxin on Cardiac, Renal, and Hepatic Biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) Development Program

(2012) Marco Metra et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

(2012) John R Teerlink et al.   LANCET

Aging attenuates the vasodilator response to relaxin

(2011) Joris van Drongelen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Maternal vasodilation in pregnancy: the emerging role of relaxin

(2011) Kirk P. Conrad   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effects of Relaxin on Arterial Dilation, Remodeling, and Mechanical Properties

(2011) Kirk P. Conrad et al.   CURRENT HYPERTENSION REPORTS

Relaxin Ameliorates Hypertension and Increases Nitric Oxide Metabolite Excretion in Angiotensin II But Not N ω -Nitro- l -Arginine Methyl Ester Hypertensive Rats

(2011) Jennifer M. Sasser et al.   HYPERTENSION

Impaired vascular responses to relaxin in diet-induced overweight female rats

(2011) Joris van Drongelen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Animal models of preeclampsia; uses and limitations

(2011) F.P. McCarthy et al.   PLACENTA

Relaxin Therapy Reverses Large Artery Remodeling and Improves Arterial Compliance in Senescent Spontaneously Hypertensive Rats

(2010) Qi Xu et al.   HYPERTENSION

Unveiling the Vasodilatory Actions and Mechanisms of Relaxin

(2010) Kirk P. Conrad   HYPERTENSION

Cervical remodeling during pregnancy and parturition

(2010) Brenda Timmons et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Scientific Rationale and Design of a Phase I Safety Study of Relaxin in Women with Severe Preeclampsia

(2009) Elaine Unemori et al.   Annals of the New York Academy of Sciences

Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester

(2009) Dilly O.C. Anumba et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarction

(2007) Silvia Nistri et al.   PHARMACOLOGICAL RESEARCH