The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na+ pump endocrine system

Na/K pump inactivation, subsarcolemmal Na measurements, and cytoplasmic ion turnover kinetics contradict restricted Na spaces in murine cardiac myocytes

(2017) Fang-Min Lu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

(2017) Thomas A Longden et al.   NATURE NEUROSCIENCE

Update on angiotensin II: new endocrine connections between the brain, adrenal glands and the cardiovascular system

(2017) Frans H H Leenen et al.   Endocrine Connections

The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction

(2017) Motoi Kobayashi et al.   PLoS One

Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells

(2017) Paula F. Kinoshita et al.   Scientific Reports

Logical Issues With the Pressure Natriuresis Theory of Chronic Hypertension

(2016) Theodore W. Kurtz et al.   AMERICAN JOURNAL OF HYPERTENSION

Glutathionylation-Dependence of Na + -K + -Pump Currents Can Mimic Reduced Subsarcolemmal Na + Diffusion

(2016) Alvaro Garcia et al.   BIOPHYSICAL JOURNAL

Endogenous cardiac steroids in animal models of mania

(2016) Anastasia Hodes et al.   BIPOLAR DISORDERS

Vasodysfunction That Involves Renal Vasodysfunction, Not Abnormally Increased Renal Retention of Sodium, Accounts for the Initiation of Salt-Induced HypertensionResponse to Morris et al

(2016) R. Curtis Morris et al.   CIRCULATION

Renal Dysfunction, Rather Than Nonrenal Vascular Dysfunction, Mediates Salt-Induced HypertensionResponse to Hall

(2016) John E. Hall   CIRCULATION

Structural analysis of the α subunit of Na + /K + ATPase genes in invertebrates

(2016) Rahma Thabet et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Endogenous Ouabain

(2016) John M. Hamlyn et al.   HYPERTENSION

Endogenous ouabain and aldosterone are coelevated in the circulation of patients with essential hypertension

(2016) Stefano Tentori et al.   JOURNAL OF HYPERTENSION

Evolution of the α-Subunit of Na/K-ATPase from Paramecium to Homo sapiens: Invariance of Transmembrane Helix Topology

(2016) Gene A. Morrill et al.   JOURNAL OF MOLECULAR EVOLUTION

Pivotal role of α2 Na+pumps and their high affinity ouabain binding site in cardiovascular health and disease

(2016) Mordecai P. Blaustein et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prevention of apoptosis averts glomerular tubular disconnection and podocyte loss in proteinuric kidney disease

(2016) Ievgeniia Burlaka et al.   KIDNEY INTERNATIONAL

Role of brain aldosterone and mineralocorticoid receptors in aldosterone-salt hypertension in rats

(2016) H.-W. Wang et al.   NEUROSCIENCE

Cardiotonic Steroids as Modulators of Neuroinflammation

(2016) Ana Maria Orellana et al.   Frontiers in Endocrinology

Endogenous Cardiotonic Steroids in Kidney Failure: A Review and an Hypothesis

(2015) John M. Hamlyn et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Expression of rat Na-K-ATPase α2 enables ion pumping but not ouabain-induced signaling in α1-deficient porcine renal epithelial cells

(2015) Joe Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Letter to the Editor concerning Baecher et al. (Clin Chim Acta 2014;431:87–92)

(2015) Mordecai P. Blaustein   CLINICA CHIMICA ACTA

Correspondence concerning the article No endogenous ouabain is detectable in human plasma by ultra-sensitive UPLC-MS/MS. Clin Chim Acta. 2014;431:87-92 by S. Baecher et al.

(2015) Michael Vogeser et al.   CLINICA CHIMICA ACTA

Effects of mood stabilizers on oxidative stress-induced cell death signaling pathways in the brains of rats subjected to the ouabain-induced animal model of mania

(2015) Samira S. Valvassori et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Endogenous Ouabain: An Old Cardiotonic Steroid as a New Biomarker of Heart Failure and a Predictor of Mortality after Cardiac Surgery

(2015) Marco Simonini et al.   Biomed Research International

Actions of Circulating Angiotensin II and Aldosterone in the Brain Contributing to Hypertension

(2014) F. H. H. Leenen   AMERICAN JOURNAL OF HYPERTENSION

Why isn't endogenous ouabain more widely accepted?

(2014) Mordecai P. Blaustein   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Digitalis-induced cell signaling by the sodium pump: On the relation of Src to Na+/K+-ATPase

(2014) Marjorie E. Gable et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

No endogenous ouabain is detectable in human plasma by ultra-sensitive UPLC-MS/MS

(2014) Silvia Baecher et al.   CLINICA CHIMICA ACTA

The central renin–angiotensin system and sympathetic nerve activity in chronic heart failure

(2014) Irving H. Zucker et al.   CLINICAL SCIENCE

Endogenous Ouabain Is Not Ouabain

(2014) Lynley K. Lewis et al.   HYPERTENSION

Reduction in Maternal Circulating Ouabain Impairs Offspring Growth and Kidney Development

(2014) M. Dvela-Levitt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway

(2014) Xiaofei Yan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A new clinical multivariable model that predicts postoperative acute kidney injury: impact of endogenous ouabain

(2014) M. Simonini et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Increased Na+/Ca2+ Exchanger Expression/Activity Constitutes a Point of Inflection in the Progression to Heart Failure of Hypertensive Rats

(2014) Jesica S. Rodriguez et al.   PLoS One

Wistar Rats Resistant to the Hypertensive Effects of Ouabain Exhibit Enhanced Cardiac Vagal Activity and Elevated Plasma Levels of Calcitonin Gene-Related Peptide

(2014) Elham Ghadhanfar et al.   PLoS One

Neuroendocrine Humoral and Vascular Components in the Pressor Pathway for Brain Angiotensin II: A New Axis in Long Term Blood Pressure Control

(2014) John M. Hamlyn et al.   PLoS One

Knockout of the Na,K-ATPase α2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction

(2013) Tara N. Rindler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cell Signaling Associated with Na+/K+-ATPase: Activation of Phosphatidylinositide 3-Kinase IA/Akt by Ouabain Is Independent of Src

(2013) Jian Wu et al.   BIOCHEMISTRY

Kainate-induced calcium overload of cortical neurons in vitro: Dependence on expression of AMPAR GluA2-subunit and down-regulation by subnanomolar ouabain

(2013) Polina A. Abushik et al.   CELL CALCIUM

Preoperative Endogenous Ouabain Predicts Acute Kidney Injury in Cardiac Surgery Patients*

(2013) Elena Bignami et al.   CRITICAL CARE MEDICINE

Anatomy of Success

(2013) Young S. Oh et al.   HYPERTENSION

Amino acid substitutions of Na,K-ATPase conferring decreased sensitivity to cardenolides in insects compared to mammals

(2013) Safaa Dalla et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults

(2013) Paul A. James et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Involvement of Reactive Oxygen Species in a Feed-forward Mechanism of Na/K-ATPase-mediated Signaling Transduction

(2013) Yanling Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ouabain-digoxin antagonism in rat arteries and neurones

(2013) Hong Song et al.   JOURNAL OF PHYSIOLOGY-LONDON

Management of heart failure

(2013) Henry Krum et al.   MEDICAL JOURNAL OF AUSTRALIA

High Vascular Tone of Mouse Femoral Arteries In Vivo Is Determined by Sympathetic Nerve Activity Via α1A- and α1D-Adrenoceptor Subtypes

(2013) Joseph Zacharia et al.   PLoS One

Crystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site

(2013) M. Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase

(2012) John N. Lorenz et al.   AMERICAN JOURNAL OF HYPERTENSION

Activation of c-SRC underlies the differential effects of ouabain and digoxin on Ca2+ signaling in arterial smooth muscle cells

(2012) Alessandra Zulian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Normal pregnancy: mechanisms underlying the paradox of a ouabain-resistant state with elevated endogenous ouabain, suppressed arterial sodium calcium exchange, and low blood pressure

(2012) Brandiese E. Jacobs et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Central Sympathetic Inhibition by Mineralocorticoid Receptor But Not Angiotensin II Type 1 Receptor Blockade

(2012) Frans H.H. Leenen et al.   HYPERTENSION

Central neuromodulatory pathways regulating sympathetic activity in hypertension

(2012) Alexander Gabor et al.   JOURNAL OF APPLIED PHYSIOLOGY

Tissue-specific Role of the Na,K-ATPase α2 Isozyme in Skeletal Muscle

(2012) Tatiana L. Radzyukevich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous ouabain regulates cell viability

(2011) Moran Dvela et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypertension from chronic central sodium chloride in mice is mediated by the ouabain-binding site on the Na,K-ATPase α2-isoform

(2011) James W. Van Huysse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Increased arterial smooth muscle Ca2+ signaling, vasoconstriction, and myogenic reactivity in Milan hypertensive rats

(2011) Cristina I. Linde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension

(2011) Mordecai P. Blaustein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neural Mechanisms of Angiotensin II–Salt Hypertension: Implications for Therapies Targeting Neural Control of the Splanchnic Circulation

(2011) John W. Osborn et al.   CURRENT HYPERTENSION REPORTS

Neutralization of endogenous digitalis-like compounds alters catecholamines metabolism in the brain and elicits anti-depressive behavior

(2011) Inbal Goldstein et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone

(2011) Bing S. Huang et al.   EXPERIMENTAL PHYSIOLOGY

Influence of N-methyl-D-aspartate receptors on ouabain activation of nuclear factor-κB in the rat hippocampus

(2011) E.M. Kawamoto et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

(2011) Danielle Ingrid Bezerra de Vasconcelos et al.   MEDIATORS OF INFLAMMATION

Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase  3 sodium pump

(2011) G. S. Kirshenbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin

(2011) Jan A Staessen et al.   Trials

The Ouabain-Binding Site of the  2 Isoform of Na,K-ATPase Plays a Role in Blood Pressure Regulation During Pregnancy

(2010) N. Oshiro et al.   AMERICAN JOURNAL OF HYPERTENSION

Does Na+ really play a role in Ca2+ homeostasis in hypertension?

(2010) Fernanda R. Giachini et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure

(2010) Jin Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats

(2010) Alessandra Zulian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy

(2010) Arshani N. Wansapura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Physiological Significance of the Cardiotonic Steroid/Ouabain-Binding Site of the Na,K-ATPase

(2010) Jerry B Lingrel   Annual Review of Physiology

The central role of the brain aldosterone–“ouabain” pathway in salt-sensitive hypertension

(2010) Frans H.H. Leenen   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endogenous cardiotonic steroids and salt-sensitive hypertension

(2010) Olga V. Fedorova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ouabain attenuates cardiotoxicity induced by other cardiac steroids

(2010) M Nesher et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ca2+signaling in smooth muscle: TRPC6, NCX, and LNats in nanodomains

(2010) Damon Poburko et al.   Channels

Ouabain - the insulin of the heart

(2010) H. Fürstenwerth   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Alterations of Na+/K+-ATPase function in caveolin-1 knockout cardiac fibroblasts

(2010) Luis E.M. Quintas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase

(2010) Laure Yatime et al.   JOURNAL OF STRUCTURAL BIOLOGY

Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 2: Clinical Studies

(2010) C. Lanzani et al.   Science Translational Medicine

Targeted mutations in the Na,K-ATPase alpha 2 isoform confer ouabain resistance and result in abnormal behavior in mice

(2010) Tori L. Schaefer et al.   SYNAPSE

Ouabain protects against adverse developmental programming of the kidney

(2010) Juan Li et al.   Nature Communications

Altered expression and insulin-induced trafficking of Na+-K+-ATPase in rat skeletal muscle: effects of high-fat diet and exercise

(2009) Dana Galuska et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Physiological roles of endogenous ouabain in normal rats

(2009) Maoz Nesher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Marinobufagenin enhances cardiac contractility in mice with ouabain-sensitive α1 Na+-K+-ATPase

(2009) Arshani N. Wansapura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Low-dose ouabain constricts small arteries from ouabain-hypertensive rats: implications for sustained elevation of vascular resistance

(2009) Jin Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Upregulation of Na+ and Ca2+ transporters in arterial smooth muscle from ouabain-induced hypertensive rats

(2009) Maria V. Pulina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Brain renin–angiotensin–aldosterone system and ventricular remodeling after myocardial infarct: a reviewThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research.

(2009) Katherine V. Westcott et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Understanding the contribution of Guyton's large circulatory model to long-term control of arterial pressure

(2009) Jean-Pierre Montani et al.   EXPERIMENTAL PHYSIOLOGY

Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure

(2009) John W. Osborn et al.   EXPERIMENTAL PHYSIOLOGY

Mutation I810N in the  3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS

(2009) S. J. Clapcote et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cardiac glycoside binding site on the Na,K-ATPase α2 isoform plays a role in the dynamic regulation of active transport in skeletal muscle

(2009) T. L. Radzyukevich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ACTH-induced hypertension is dependent on the ouabain-binding site of the α2-Na+-K+-ATPase subunit

(2008) John N. Lorenz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Does Aldosterone Upregulate the Brain Renin-Angiotensin System in Rats With Heart Failure?

(2008) Yang Yu et al.   HYPERTENSION

Comparison of non-digitalis binding properties of digoxin-specific Fabs using direct binding methods

(2008) Mark A. Pullen et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Endogenous ouabain and cardiomyopathy in dialysis patients

(2008) P. Stella et al.   JOURNAL OF INTERNAL MEDICINE

Ouabain-Sensitive  1 Na,K-ATPase Enhances Natriuretic Response to Saline Load

(2008) E. L. Loreaux et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Analytic Reviews: Cardiac Surgery as a Cause of Acute Kidney Injury: Pathogenesis and Potential Therapies

(2008) Mitchell H. Rosner et al.   JOURNAL OF INTENSIVE CARE MEDICINE