Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway

Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma

(2014) Claudia Friesen et al.   CELL CYCLE

Hydrogen sulfide protected gastric epithelial cell from ischemia/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-κB dependent anti-inflammation pathway

(2014) Cheng Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prooxidant Properties of p66shc Are Mediated by Mitochondria in Human Cells

(2014) Evgeny R. Galimov et al.   PLoS One

Cell Signaling Associated with Na+/K+-ATPase: Activation of Phosphatidylinositide 3-Kinase IA/Akt by Ouabain Is Independent of Src

(2013) Jian Wu et al.   BIOCHEMISTRY

Thrombin-induced NF-κB activation and IL-8/CXCL8 release is mediated by c-Src-dependent Shc, Raf-1, and ERK pathways in lung epithelial cells

(2013) Chien-Huang Lin et al.   CELLULAR SIGNALLING

Calcium oscillations triggered by cardiotonic steroids

(2013) Jacopo M. Fontana et al.   FEBS Journal

Nanomolar ouabain augments Ca2+signalling in rat hippocampal neurones and glia

(2013) Hong Song et al.   JOURNAL OF PHYSIOLOGY-LONDON

β-Amyloid-evoked Apoptotic Cell Death is Mediated Through MKK6–p66shc Pathway

(2013) Muneesa Bashir et al.   NEUROMOLECULAR MEDICINE

Ouabain downregulates Mcl-1 and sensitizes lung cancer cells to TRAIL-induced apoptosis

(2012) Pithi Chanvorachote et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

(−)Clausenamide facilitates synaptic transmission at hippocampal Schaffer collateral-CA1 synapses

(2012) Na Ning et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pro-death and pro-survival properties of ouabain in U937 lymphoma derived cells

(2012) Francesca Cuozzo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mechanistic distinction between activation and inhibition of (Na++K+)-ATPase-mediated Ca2+ influx in cardiomyocytes

(2011) Kai Y. Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1

(2011) Zhengguang Wang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Distinct Transcriptional Regulation of Human Large Conductance Voltage- and Calcium-activated K+Channel Gene (hSlo1) by Activated Estrogen Receptor α and c-Src Tyrosine Kinase

(2011) Shahab M. Danesh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src

(2011) J Jung et al.   ONCOGENE

Cisplatin induces apoptosis through the ERK–p66shc pathway in renal proximal tubule cells

(2010) Jeb S. Clark et al.   CANCER LETTERS

p66shcInhibits Insulin-like Growth Factor-I Signaling via Direct Binding to Src through Its Polyproline and Src Homology 2 Domains, Resulting in Impairment of Src Kinase Activation

(2010) Gang Xi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell death: Insights into the ultrastructure of mitochondria

(2010) C. Ulivieri   TISSUE & CELL

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

TARGETING THE α 1 SUBUNIT OF THE SODIUM PUMP TO COMBAT GLIOBLASTOMA CELLS

(2009) Florence Lefranc et al.   NEUROSURGERY

Src activation generates reactive oxygen species and impairs metabolism–secretion coupling in diabetic Goto–Kakizaki and ouabain-treated rat pancreatic islets

(2008) R. Kominato et al.   DIABETOLOGIA

Cardiac Glycosides as Novel Cancer Therapeutic Agents

(2008) R. A. Newman et al.   MOLECULAR INTERVENTIONS

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY