The role of extracellular matrix stiffness in megakaryocyte and platelet development and function

A new path to platelet production through matrix sensing

(2017) Vittorio Abbonante et al.   HAEMATOLOGICA

Evidence for shear-mediated Ca2+entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line

(2017) Zeki Ilkan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix

(2017) S V Glavey et al.   LEUKEMIA

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

Bone marrow involvement in systemic lupus erythematosus

(2017) E. Chalayer et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

The role of the extracellular matrix in primary myelofibrosis

(2017) O Leiva et al.   Blood Cancer Journal

Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

(2017) M Rocio Servin-Vences et al.   eLife

A new path to platelet production through matrix sensing

(2017) Vittorio Abbonante et al.   HAEMATOLOGICA

Marrow-inspired matrix cues rapidly affect early fate decisions of hematopoietic stem and progenitor cells

(2017) Ji Sun Choi et al.   Science Advances

In vitro fibrillogenesis of tropocollagen type III in collagen type I affects its relative fibrillar topology and mechanics

(2017) Meisam Asgari et al.   Scientific Reports

Major Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures

(2016) Vitalba Di Stefano et al.   AMERICAN JOURNAL OF PATHOLOGY

Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis

(2016) Aaron C. Petrey et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysyl oxidase is associated with increased thrombosis and platelet reactivity

(2016) S. Matsuura et al.   BLOOD

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation

(2016) A. Aguilar et al.   BLOOD

Hyaluronan based hydrogels provide an improved model to study megakaryocyte–matrix interactions

(2016) Manuela Currao et al.   EXPERIMENTAL CELL RESEARCH

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4

(2016) Hannah Uckelmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-term findings from COMFORT-II, a phase 3 study of ruxolitinib vs best available therapy for myelofibrosis

(2016) C N Harrison et al.   LEUKEMIA

Fibrillin-1 microfibrils influence adult bone marrow hematopoiesis

(2016) Silvia Smaldone et al.   MATRIX BIOLOGY

The Role of PIEZO2 in Human Mechanosensation

(2016) Alexander T. Chesler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brief Report: Alternative Splicing of Extra Domain A (EIIIA) of Fibronectin Plays a Tissue-Specific Role in Hematopoietic Homeostasis

(2016) Alessandro Malara et al.   STEM CELLS

Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies

(2015) C. A. Di Buduo et al.   BLOOD

United Kingdom immune thrombocytopenia registry: retrospective evaluation of bone marrow fibrosis in adult patients with primary immune thrombocytopenia and correlation with clinical findings

(2015) Hasan Rizvi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis

(2015) Ayumi Iwasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of hematopoietic progenitor cell fate in vitro by varying collagen oligomer matrix stiffness in the presence or absence of osteoblasts

(2015) Brahmananda Reddy Chitteti et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Mechanics of intact bone marrow

(2015) Lauren E. Jansen et al.   Journal of the Mechanical Behavior of Biomedical Materials

Differential clinical effects of different mutation subtypes in CALR-mutant myeloproliferative neoplasms

(2015) D Pietra et al.   LEUKEMIA

Stress controls the mechanics of collagen networks

(2015) Albert James Licup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1 regulates mechanotransductive release of ATP from human RBCs

(2015) Eyup Cinar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

(2015) Viktor Lukacs et al.   Nature Communications

Myeloproliferative Neoplasms

(2015) Ayalew Tefferi et al.   JAMA Oncology

Mutations in PIEZO2 Cause Gordon Syndrome, Marden-Walker Syndrome, and Distal Arthrogryposis Type 5

(2014) Margaret J. McMillin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Extracellular matrix: A dynamic microenvironment for stem cell niche

(2014) Francesca Gattazzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Bone marrow fibrosis in 66 patients with immune thrombocytopenia treated with thrombopoietin-receptor agonists: a single-center, long-term follow-up

(2014) W. Ghanima et al.   HAEMATOLOGICA

The importance of calcium in the regulation of megakaryocyte function

(2014) C. Andrea Di Buduo et al.   HAEMATOLOGICA

Autoimmune myelofibrosis: an update on morphologic features in 29 cases and review of the literature

(2014) Maria E. Vergara-Lluri et al.   HUMAN PATHOLOGY

Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes

(2014) Sviatoslav N. Bagriantsev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation

(2014) Yongzhi Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The expression of lysyl-oxidase gene family members in myeloproliferative neoplasms

(2013) T. Tadmor et al.   AMERICAN JOURNAL OF HEMATOLOGY

Megakaryocyte polyploidy is inhibited by lysyl oxidase propeptide

(2013) Alexia Eliades et al.   CELL CYCLE

The role of cytokines in the initiation and progression of myelofibrosis

(2013) Hans C. Hasselbalch   CYTOKINE & GROWTH FACTOR REVIEWS

Extracellular Matrix Remodeling by Bone Marrow Fibroblast-like Cells Correlates with Disease Progression in Multiple Myeloma

(2013) Astrid Slany et al.   JOURNAL OF PROTEOME RESEARCH

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

(2013) J. Nangalia et al.   NEW ENGLAND JOURNAL OF MEDICINE

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

(2013) B. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Plasminogen Activator Inhibitor Type-1 Activity Enhances Rapid and Sustainable Hematopoietic Regeneration

(2013) Abd Aziz Ibrahim et al.   STEM CELLS

Megakaryocytes Contribute to the Bone Marrow-Matrix Environment by Expressing Fibronectin, Type IV Collagen, and Laminin

(2013) Alessandro Malara et al.   STEM CELLS

Heparan Sulfate: A Ubiquitous Glycosaminoglycan with Multiple Roles in Immunity

(2013) David Anak Simon Davis et al.   Frontiers in Immunology

Potentiated activation of VLA-4 and VLA-5 accelerates proplatelet-like formation

(2012) Takuya Matsunaga et al.   ANNALS OF HEMATOLOGY

The combined influence of substrate elasticity and ligand density on the viability and biophysical properties of hematopoietic stem and progenitor cells

(2012) Ji S. Choi et al.   BIOMATERIALS

Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection

(2012) N. Papadantonakis et al.   BLOOD

Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration

(2012) A. Nakamura-Ishizu et al.   BLOOD

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study

(2012) M. N. Saleh et al.   BLOOD

Repeated short-term use of eltrombopag in patients with chronic immune thrombocytopenia (ITP)

(2012) James B. Bussel et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hyaluronan Expressed by the Hematopoietic Microenvironment Is Required for Bone Marrow Hematopoiesis

(2012) Valentina Goncharova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

uPA and MMP-2 were involved in self-assembled network formation in a two dimensional co-culture model of bone marrow stromal cells and endothelial cells

(2012) Haiyan Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The unique contribution of ion channels to platelet and megakaryocyte function

(2012) M. P. MAHAUT-SMITH   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The European Consensus on grading of bone marrow fibrosis allows a better prognostication of patients with primary myelofibrosis

(2012) Umberto Gianelli et al.   MODERN PATHOLOGY

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

Ion channels in the regulation of platelet migration

(2011) Eva-Maria Schmidt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The critical role of agrin in the hematopoietic stem cell niche

(2011) C. Mazzon et al.   BLOOD

Extracellular matrix structure and nano-mechanics determine megakaryocyte function

(2011) A. Malara et al.   BLOOD

Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells

(2011) F. Di Giacomo et al.   HAEMATOLOGICA

Control of Megakaryocyte Expansion and Bone Marrow Fibrosis by Lysyl Oxidase

(2011) Alexia Eliades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes

(2011) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations responsible for MYH9-related thrombocytopenia impair SDF-1-driven migration of megakaryoblastic cells

(2011) Valeria Bozzi et al.   THROMBOSIS AND HAEMOSTASIS

TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool

(2010) H. Nakajima et al.   BLOOD

Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A

(2010) A. Malara et al.   BLOOD

Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts

(2010) T. A. M. Steevels et al.   HAEMATOLOGICA

Cytoskeletal mechanics of proplatelet maturation and platelet release

(2010) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Kv1.3 is the exclusive voltage-gated K+channel of platelets and megakaryocytes: roles in membrane potential, Ca2+signalling and platelet count

(2010) Conor McCloskey et al.   JOURNAL OF PHYSIOLOGY-LONDON

Store-operated CRAC channels: function in health and disease

(2010) Anant B. Parekh   NATURE REVIEWS DRUG DISCOVERY

Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) Regulates Hematopoiesis and Bone Formation In Vivo

(2010) Yi Shen et al.   PLoS One

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

The influence of extracellular matrix proteins and mesenchymal stem cells on erythropoietic cell maturation

(2010) P. Lazar-Karsten et al.   VOX SANGUINIS

Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim

(2009) D. J. Kuter et al.   BLOOD

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

(2009) Charles K. Thodeti et al.   CIRCULATION RESEARCH

VLA-5-mediated Adhesion to Fibronectin Accelerates Hemin-stimulated Erythroid Differentiation of K562 Cells through Induction of VLA-4 Expression

(2009) Rika Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Force probing surfaces of living cells to molecular resolution

(2009) Daniel J Müller et al.   Nature Chemical Biology

Regulation of cell signalling by uPAR

(2009) Harvey W. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unrelated stem cell transplant for infantile idiopathic myelofibrosis

(2009) Jennifer Domm et al.   PEDIATRIC BLOOD & CANCER

Bone Marrow Osteoblastic Niche: A New Model to Study Physiological Regulation of Megakaryopoiesis

(2009) Isabella Pallotta et al.   PLoS One

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Thrombospondins function as regulators of angiogenesis

(2009) Paul Bornstein   Journal of Cell Communication and Signaling

Bone Morphogenetic Proteins Are Overexpressed in the Bone Marrow of Primary Myelofibrosis and Are Apparently Induced by Fibrogenic Cytokines

(2008) Oliver Bock et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysyl Oxidase Oxidizes Cell Membrane Proteins and Enhances the Chemotactic Response of Vascular Smooth Muscle Cells

(2008) Héctor A. Lucero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The lung megakaryocytes and pulmonary fibrosis in systemic sclerosis

(2008) Jecko Thachil   MEDICAL HYPOTHESES