Identification of T-cell epitopes from benzylpenicillin conjugated to human serum albumin and implication in penicillin allergy

Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients

(2017) Xiaoli Meng et al.   JOURNAL OF IMMUNOLOGY

The Effect of Inhibitory Signals on the Priming of Drug Hapten–Specific T Cells That Express Distinct Vβ Receptors

(2017) Andrew Gibson et al.   JOURNAL OF IMMUNOLOGY

Bioinspired Design and Oriented Synthesis of Immunogenic Site-Specifically Penicilloylated Peptides

(2016) Noémie Scornet et al.   BIOCONJUGATE CHEMISTRY

Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune Receptors

(2015) Werner J. Pichler et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

The Tumor Antigen Cyclin B1 Hosts Multiple CD4 T Cell Epitopes Differently Recognized by Pre-Existing Naive and Memory Cells in Both Healthy and Cancer Donors

(2015) Claire Chevaleyre et al.   JOURNAL OF IMMUNOLOGY

A Population Response Analysis Approach To Assign Class II HLA-Epitope Restrictions

(2015) Sinu Paul et al.   JOURNAL OF IMMUNOLOGY

Decision-making critical amino acids: role in designing peptide vaccines for eliciting Th1 and Th2 immune response

(2014) Khurram Mushtaq et al.   AMINO ACIDS

Mass Spectrometric Strategies for the Identification and Characterization of Human Serum Albumin Covalently Adducted by Amoxicillin: Ex Vivo Studies

(2014) Davide Garzon et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The importance of hapten–protein complex formation in the development of drug allergy

(2014) Lee Faulkner et al.   Current Opinion in Allergy and Clinical Immunology

The effect of haptens on protein-carrier immunogenicity

(2014) Tal Gefen et al.   IMMUNOLOGY

Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22-Secreting T Cells and the Influence of PD-1 on Effector T Cell Function

(2014) A. Gibson et al.   JOURNAL OF IMMUNOLOGY

The immune epitope database (IEDB) 3.0

(2014) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

Identification and frequency of circulating CD4+T lymphocytes specific to Benzylpenicillin in healthy donors

(2013) C. Nhim et al.   ALLERGY

β-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis

(2013) Rosalind E. Jenkins et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Hierarchy of CD4 T Cell Epitopes of the ANRS Lipo5 Synthetic Vaccine Relies on the Frequencies of Pre-Existing Peptide-Specific T Cells in Healthy Donors

(2013) F. A. Castelli et al.   JOURNAL OF IMMUNOLOGY

The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude

(2012) M. K. Jenkins et al.   JOURNAL OF IMMUNOLOGY

Protein haptenation by amoxicillin: High resolution mass spectrometry analysis and identification of target proteins in serum

(2012) Adriana Ariza et al.   Journal of Proteomics

Immune epitope database analysis resource

(2012) Y. Kim et al.   NUCLEIC ACIDS RESEARCH

Quantitative analysis of the CD4 T-cell repertoire specific to therapeutic antibodies in healthy donors

(2011) Stephanie Delluc et al.   FASEB JOURNAL

Immune pathomechanism of drug hypersensitivity reactions

(2011) Werner J. Pichler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

European Surveillance of Antimicrobial Consumption (ESAC): quality appraisal of antibiotic use in Europe

(2011) Niels Adriaenssens et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis

(2011) P. Whitaker et al.   JOURNAL OF IMMUNOLOGY

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

(2011) X. Meng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Evaluation of a New Routine Diagnostic Test for Immunoglobulin E Sensitization to Neuromuscular Blocking Agents

(2010) Dominique Laroche et al.   ANESTHESIOLOGY

Quantification of the preexisting CD4 T-cell repertoire specific for human erythropoietin reveals its immunogenicity potential

(2010) S. Delluc et al.   BLOOD

Molecular Determinants of T Cell Epitope Recognition to the Common Timothy Grass Allergen

(2010) C. Oseroff et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of Drug-Induced Allergy

(2009) Benno Schnyder et al.   MAYO CLINIC PROCEEDINGS

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSAin vitroandin vivo

(2009) Rosalind E. Jenkins et al.   Proteomics Clinical Applications

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1

(2009) Rym Megherbi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY