Article
Microbiology
Amedee Ego, Lorenzo Peluso, Julie Gorham, Alberto Diosdado, Giovanni Restuccia, Jacques Creteur, Fabio Silvio Taccone
Summary: Patients with COVID-19 related ARDS had significantly longer duration and higher consumption of sedatives and NMBA compared to non-COVID ARDS patients, suggesting the need for different sedation strategies and protocols in COVID-19 patients with ARDS.
Article
Anesthesiology
Paul Michel Mertes, Nadine Petitpain, Charles Tacquard, Marion Delpuech, Cedric Baumann, Jean Marc Malinovsky, Dan Longrois, Aurelie Gouel-Cheron, Diane Le Quang, Pascal Demoly, Jean Louis Gueant, Pierre Gillet, ALPHO Study Grp
Summary: This study assessed the relationship between pholcodine exposure and NMBA-related anaphylaxis. It found that exposure to pholcodine and other quaternary ammonium compounds in the environment can increase sensitivity to NMBAs. Pholcodine and quaternary ammonium sIgEs have a high negative predictive value but a very low positive predictive value for identifying NMBA-related reactions.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Medicine, General & Internal
Choon-Kyu Cho, Minhye Change, Seok-Jin Lee, Tae-Yun Sung
Summary: The use of rocuronium did not increase the success rate of inserting the i-gel or improve surgical conditions in elderly patients. However, it did reduce peak inspiratory pressure, decrease the frequency of spontaneous breathing, lower the requirement for additional fentanyl, and shorten patients' recovery time.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Yao Chai, Longming Chen, Yahan Zhang, Liang Zhao, Zhao Meng, Junyi Chen, Chunju Li, Qingbin Meng
Summary: This study utilized carboxylatopillar[6]arene (CP6A) as a reversal agent to reverse the neuromuscular blocking effect of decamethonium (C10). The experiment confirmed the strong affinity between CP6A and C10, and showed that CP6A could decrease the concentration of C10 in mice blood and facilitate its excretion through urinary clearance, leading to rapid recovery from muscle relaxation.
CHINESE CHEMICAL LETTERS
(2022)
Article
Gastroenterology & Hepatology
Akinobu Nakata, Fumio Tanaka, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Noriko Kamata, Koichi Taira, Yasuaki Nagami, Toshio Watanabe, Yasuhiro Fujiwara
Summary: The study found that patients with eosinophilic esophagitis can be categorized into three groups based on allergic sensitization patterns. These groups showed significant differences in dysphagia prevalence and endoscopic reference scores, indicating a correlation between allergic sensitization and clinical features among EE patients.
JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Anesthesiology
Brian L. Erstad, Jeffrey F. Barletta
Summary: The choice of weight descriptor for weight-based dosing of neuromuscular blocking agents in patients with obesity remains a topic of debate, with actual body weight recommended for succinylcholine and ideal body weight or adjusted body weight recommended for non-depolarising NMBAs. Studies conducted in perioperative settings have evaluated single doses or short-term infusions of NMBAs in obese patients, with the understanding that final dosing regimens must consider patient-specific factors.
ANAESTHESIA AND INTENSIVE CARE
(2021)
Article
Anesthesiology
J. Martinez-Ubieto, C. Aragon-Benedi, J. de Pedro, L. Cea-Calvo, A. Morell, Y. Jiang, S. Cedillo, P. Ramirez-Boix, A. M. Pascual-Bellosta
Summary: This study evaluated the clinical and economic impact of introducing Sugammadex for reversing rocuronium-induced neuromuscular blockade in Spain and found that its introduction led to cost savings and reduced postoperative pulmonary complications.
BMC ANESTHESIOLOGY
(2021)
Review
Anesthesiology
Ting Lyu, Yee S. Lee, Shekhar Dhanvijay, Ross Freebairn
Summary: The use of NMBAs in patients with moderate to severe ARDS is associated with reduced ICU mortality, but does not improve oxygenation, VFDs, 28-day or 90-day mortality. It also does not significantly impact ICU-AW.
MINERVA ANESTESIOLOGICA
(2021)
Article
Medicine, General & Internal
Sung-Hyey Byun, Jae-Min Jeon
Summary: The use of low-dose NMBA for IONM induction may lead to sinus pause or severe bradycardia caused by laryngocardiac reflex. Anesthesiologists should be aware of these risks and maintain adequate anesthesia depth.
Review
Biochemistry & Molecular Biology
Yasser M. Zohny, Samir M. Awad, Maha A. Rabie, Omar A. Al-Saidan
Summary: Hypertension and cardiovascular diseases pose significant medical challenges worldwide, and the development of drugs to manage hypertension is a priority. Some of these drugs, such as those with a dihydropyrimidine structure, act as effective calcium channel blockers and have been extensively studied. The synthesis of these compounds, their structure-activity relationship, and future opportunities in this field have been explored, with a focus on substitutions at specific positions to produce derivatives with antihypertensive activity. This review aims to cover these topics in detail.
Article
Cell Biology
Gabor Cserni, Endre Kalman, Nora Udvarhelyi, Eszter Papp, Isabel Grote, Stephan Bartels, Matthias Christgen, Hans Kreipe, Janina Kulka
Summary: This study tested the value of using E-cadherin immunohistochemistry (IHC) to recognize invasive lobular carcinoma (ILC). The results showed that the routine use of E-cadherin IHC can decrease typing uncertainty and improve diagnostic accuracy, although there are still cases of uncertain ILC diagnosis.
Article
Virology
Maria Infantino, Mariangela Manfredi, Valentina Grossi, Barbara Lari, Sergio Fabbri, Maurizio Benucci, Alberto Fortini, Arianna Damiani, Emanuela Maria Mobilia, Marta Panciroli, Silvia Pancani, Giampaola Pesce
Summary: Including IgA antibody determination in serological tests of COVID-19 diagnosis can improve diagnostic accuracy. IgA antibodies play a crucial role in bridging the serological gap of COVID-19, with their concentrations potentially being more than twice as high as IgG. Variations among anti-SARS-CoV-2 IgG assays should be taken into consideration when interpreting results.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Rui Tang, Xiaohong Lyu, Yuxi Liu, Ruiqi Wang, Lianglu Wang, Hong Li, Jinlyu Sun, Yuxiang Zhi, Jianqing Gu, Kai Guan, Liping Wen, Zixi Wang, Lisha Li, Le Cui, Yingyang Xu, Junxiong Zhou, Tao Xu, Jia Yin
Summary: The study demonstrated that the extracts of D. pteronyssinus for skin prick test were highly accurate and safe in diagnosing D. pteronyssinus allergy, suggesting their potential recommendation for clinical use.
CHINESE MEDICAL JOURNAL
(2022)
Article
Anesthesiology
Tomonori Takazawa, Tatsuo Horiuchi, Kazuhiro Nagumo, Yuki Sugiyama, Tsubasa Akune, Yasuhiro Amano, Masataka Fukuda, Takashi Haraguchi, Chika Ishibashi, Eiki Kanemaru, Takao Kato, Keiichi Katoh, Takashi Kawano, Tsukasa Kochiyama, Michioki Kuri, Akihide Kurita, Yoshikazu Matsuoka, Takahiro Muramatsu, Masaki Orihara, Yutaka Saito, Nobukazu Sato, Toshie Shiraishi, Kaoru Suzuki, Miyuki Takahashi, Toshifumi Takahashi, Kumiko Tanabe, Akihiro Tomioka, Yukinari Tomita, Tatsuya Tsuji, Iwao Watanabe, Takashige Yamada, Nagahide Yoshida, Masao Yamaguchi, Shigeru Saito
Summary: This study describes the utility of a newly developed tool for identifying patients with a high possibility of anaphylaxis and investigates the frequency of anaphylaxis with each drug during the perioperative period in Japan. The developed composite score, which includes skin tests and basophil activation tests, improved the certainty of anaphylaxis diagnosis. The top causative agents were rocuronium, sugammadex, and cefazolin.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Medicine, General & Internal
Jung Yeob Han, Hun Lee, Jae Lim Chung, Young Jun Kim, Jae Yong Kim, Hungwon Tchah
Summary: The study investigated the IgE detection rate and allergen patterns in patients with isolated allergic conjunctivitis using the MAST-immunoblot assay. The most frequently sensitizing allergens were house dust mites and Alternaria. Men had a higher TIgE positive rate while younger patients showed higher sensitization to allergens.
JOURNAL OF CLINICAL MEDICINE
(2021)