Biophysical and biomolecular determination of cellular age in humans

Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes

(2016) Vivian C. Hecht et al.   JOURNAL OF CELL BIOLOGY

MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents

(2016) M Y Shah et al.   ONCOGENE

Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives

(2016) Mikhail V. Blagosklonny   Aging-US

The Mechanobiology of Aging

(2015) Jude M. Phillip et al.   Annual Review of Biomedical Engineering

High-Throughput Assessment of Cellular Mechanical Properties

(2015) Eric M. Darling et al.   Annual Review of Biomedical Engineering

Cytoskeletal tension induces the polarized architecture of the nucleus

(2015) Dong-Hwee Kim et al.   BIOMATERIALS

Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin

(2015) Daniel M. Waldera Lupa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Statistical analysis of cell migration in 3D using the anisotropic persistent random walk model

(2015) Pei-Hsun Wu et al.   Nature Protocols

Quantification of biological aging in young adults

(2015) Daniel W. Belsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of cellular morpho-phenotypes in cancer metastasis

(2015) Pei-Hsun Wu et al.   Scientific Reports

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Advances in Geroscience: Impact on Healthspan and Chronic Disease

(2014) J. B. Burch et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Three-dimensional cell migration does not follow a random walk

(2014) P.-H. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity

(2013) Yao Lu et al.   ANALYTICAL CHEMISTRY

Modulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repair

(2013) Qiongyu Guo et al.   BIOMATERIALS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Nuclear Mechanics and Mechanotransduction in Health and Disease

(2013) Philipp Isermann et al.   CURRENT BIOLOGY

Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution

(2013) Allison B. Chambliss et al.   FASEB JOURNAL

Functional interplay between the cell cycle and cell phenotypes

(2013) Wei-Chiang Chen et al.   Integrative Biology

Morphological Effects on Expression of Growth Differentiation Factor 15 (GDF15), a Marker of Metastasis

(2013) Koh Meng Aw Yong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle

(2013) Ran Kafri et al.   NATURE

The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

(2013) Dong-Hwee Kim et al.   Soft Matter

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

High-throughput ballistic injection nanorheology to measure cell mechanics

(2012) Pei-Hsun Wu et al.   Nature Protocols

Stiffening of Human Skin Fibroblasts with Age

(2011) Christian Schulze et al.   CLINICS IN PLASTIC SURGERY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization

(2011) Christopher M. Hale et al.   JOURNAL OF CELL SCIENCE

Sex Differences in Human Biological Aging

(2011) E. Nakamura et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Epigenetic Predictor of Age

(2011) Sven Bocklandt et al.   PLoS One

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Age-associated increase in heterochromatic marks in murine and primate tissues

(2010) Jill A. Kreiling et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Cellular Heterogeneity: Do Differences Make a Difference?

(2010) Steven J. Altschuler et al.   CELL

A distinctive role for focal adhesion proteins in three-dimensional cell motility

(2010) Stephanie I. Fraley et al.   NATURE CELL BIOLOGY

Mechanical properties of cells and ageing

(2009) Maria N. Starodubtseva   AGEING RESEARCH REVIEWS

Delayed kinetics of DNA double-strand break processing in normal and pathological aging

(2009) Olga A. Sedelnikova et al.   AGING CELL

Particle-Tracking Microrheology of Living Cells: Principles and Applications

(2009) Denis Wirtz   Annual Review of Biophysics

Non-genetic cell-to-cell variability and the consequences for pharmacology

(2009) Mario Niepel et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Future of Cancer Incidence in the United States: Burdens Upon an Aging, Changing Nation

(2009) Benjamin D. Smith et al.   JOURNAL OF CLINICAL ONCOLOGY

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA