Perturbations of Heart Development and Function in Cardiomyocytes from Human Embryonic Stem Cells with Trisomy 21

Domains of genome-wide gene expression dysregulation in Down’s syndrome

(2014) Audrey Letourneau et al.   NATURE

The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome

(2013) M. R. Sailani et al.   GENOME RESEARCH

Novel and functional variants within the TBX18 gene promoter in ventricular septal defects

(2013) Liming Ma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Molecular and Functional Evidence of HCN4 and Caveolin-3 Interaction During Cardiomyocyte Differentiation from Human Embryonic Stem Cells

(2013) Alexis Bosman et al.   STEM CELLS AND DEVELOPMENT

Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation

(2013) Christiana Polydorou et al.   Nature Communications

Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes

(2012) Michelangelo Paci et al.   Biomedical Engineering Online

Trisomy Correction in Down Syndrome Induced Pluripotent Stem Cells

(2012) Li B. Li et al.   Cell Stem Cell

Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis

(2012) P. Vijayaraj et al.   DEVELOPMENT

Modeling neurogenesis impairment in down syndrome with induced pluripotent stem cells from Trisomy 21 amniotic fluid cells

(2012) Huai-En Lu et al.   EXPERIMENTAL CELL RESEARCH

Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors

(2012) J. F. Islas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells

(2012) S. T. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology

(2012) James A. Briggs et al.   STEM CELLS

Mechanisms of T-box gene function in the developing heart

(2011) F. Greulich et al.   CARDIOVASCULAR RESEARCH

Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines

(2011) Christoph Bock et al.   CELL

ETS-dependent regulation of a distal Gata4 cardiac enhancer

(2011) William Schachterle et al.   DEVELOPMENTAL BIOLOGY

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

(2011) Juan Sandoval et al.   Epigenetics

Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG

(2011) L H Mochmann et al.   ONCOGENE

Derivation of three new human embryonic stem cell lines

(2010) Cara K. Bradley et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Common Variation in ISL1 Confers Genetic Susceptibility for Human Congenital Heart Disease

(2010) Kristen N. Stevens et al.   PLoS One

Human Embryonic Stem Cells as Models for Aneuploid Chromosomal Syndromes

(2010) Juan-Carlos Biancotti et al.   STEM CELLS

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

A regulatory pathway involving Notch1/β-catenin/Isl1 determines cardiac progenitor cell fate.

(2009) Chulan Kwon et al.   NATURE CELL BIOLOGY

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RETRACTED: Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts

(2008) Donald E. Kuhn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Trisomy 21 and Down syndrome: a short review

(2008) CA. Sommer et al.   BRAZILIAN JOURNAL OF BIOLOGY

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

Twist1 function in endocardial cushion cell proliferation, migration, and differentiation during heart valve development

(2008) Elaine L. Shelton et al.   DEVELOPMENTAL BIOLOGY

Identification of downstream genetic pathways of Tbx1 in the second heart field

(2008) Jun Liao et al.   DEVELOPMENTAL BIOLOGY

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Characterization of TBX20 in human hearts and its regulation by TFAP2

(2008) Stefanie Hammer et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Functional role of Notch signaling in the developing and postnatal heart

(2008) Mohamed Nemir et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Quantitative Proteomics Characterization of a Mouse Embryonic Stem Cell Model of Down Syndrome

(2008) Yuqin Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Marked differences in differentiation propensity among human embryonic stem cell lines

(2008) Kenji Osafune et al.   NATURE BIOTECHNOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH