Insights into the regulation of neuronal viability by nucleophosmin/B23

AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo

(2015) Kim-Ann Saal et al.   NEUROBIOLOGY OF DISEASE

AKT regulates NPM dependent ARF localization and p53mut stability in tumors

(2015) Garth Hamilton et al.   Oncotarget

Granulocyte colony-stimulating factor improves neuron survival in experimental spinal cord injury by regulating nucleophosmin-1 expression

(2014) Yuji Guo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis

(2014) Athanassios Kotsinas et al.   Frontiers in Genetics

Nucleolar dysfunction in Huntington's disease

(2013) Junghee Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A neuroprotective phase precedes striatal degeneration upon nucleolar stress

(2013) G Kreiner et al.   CELL DEATH AND DIFFERENTIATION

SOD2 in mitochondrial dysfunction and neurodegeneration

(2013) James M. Flynn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing

(2013) Katherine E. Sloan et al.   JOURNAL OF CELL BIOLOGY

Pharmacologic Inhibition of ROCK2 Suppresses Amyloid-  Production in an Alzheimer's Disease Mouse Model

(2013) J. H. Herskowitz et al.   JOURNAL OF NEUROSCIENCE

Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib

(2013) M Huang et al.   LEUKEMIA

In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain

(2013) M. Bergeron et al.   NEUROSCIENCE

S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1–GAPDH death cascade

(2012) Sang Bae Lee et al.   JOURNAL OF CELL BIOLOGY

The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation

(2012) Frédéric Lessard et al.   NUCLEIC ACIDS RESEARCH

Emerging roles of the neuronal nucleolus

(2012) Michal Hetman et al.   TRENDS IN NEUROSCIENCES

Nucleolar stress characterized by downregulation of nucleophosmin: A novel cause of neuronal degeneration

(2011) Esther Magdalena Marquez-Lona et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disruption of ATP binding destabilizes NPM/B23 and inhibits anti-apoptotic function

(2011) Joung-Woo Choi et al.   BMB Reports

PI(3,4,5)P3 regulates the interaction between Akt and B23 in the nucleus

(2011) Il-Sun Kwon et al.   BMB Reports

Nucleophosmin/B23 interacts with p21WAF1/CIP1 and contributes to its stability

(2011) Jianyong Xiao et al.   CELL CYCLE

Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin

(2011) N Khandelwal et al.   CELL DEATH AND DIFFERENTIATION

Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling

(2011) C. Rieker et al.   JOURNAL OF NEUROSCIENCE

Gadd45a protects against cell death in dorsal root ganglion neurons following peripheral nerve injury

(2011) Chung-Ren Lin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death

(2011) Jaume Folch et al.   NEUROTOXICITY RESEARCH

Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease

(2011) Maciej Pietrzak et al.   PLoS One

Assembly and disassembly of the nucleolus during the cell cycle

(2011) Danièle Hernandez-Verdun   Nucleus

Critical role of the JNK-p53-GADD45α apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons

(2010) Hye Joung Choi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3

(2010) Mei-Ling Kuo et al.   CELL CYCLE

Akt2 and nucleophosmin/B23 function as an oncogenic unit in human lung cancer cells

(2010) Chung Kwon Kim et al.   EXPERIMENTAL CELL RESEARCH

Dephosphorylation of Nucleophosmin by PP1β Facilitates pRB Binding and Consequent E2F1-dependent DNA Repair

(2010) Chiao Yun Lin et al.   MOLECULAR BIOLOGY OF THE CELL

The ARF Tumor Suppressor Controls Ribosome Biogenesis by Regulating the RNA Polymerase I Transcription Factor TTF-I

(2010) Frédéric Lessard et al.   MOLECULAR CELL

RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication

(2010) M Kanai et al.   ONCOGENE

Polo-Like Kinase 2-Dependent Phosphorylation of NPM/B23 on Serine 4 Triggers Centriole Duplication

(2010) Annekatrin Krause et al.   PLoS One

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Nucleophosmin Blocks Mitochondrial Localization of p53 and Apoptosis

(2009) Sanjit Kumar Dhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleophosmin and Nucleolin Regulate K-Ras Plasma Membrane Interactions and MAPK Signal Transduction

(2009) Kerry L. Inder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoplasmic p53 and Activated Bax Regulate p53-dependent, Transcription-independent Neural Precursor Cell Apoptosis

(2009) Ying Geng et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

(2009) C. Vascotto et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA Damage-Dependent Translocation of B23 and p19ARF Is Regulated by the Jun N-Terminal Kinase Pathway

(2008) O. Yogev et al.   CANCER RESEARCH

The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing

(2008) Markus Haindl et al.   EMBO REPORTS

Lysine 263 residue of NPM/B23 is essential for regulating ATP binding and B23 stability

(2008) Joung Woo Choi et al.   FEBS LETTERS

Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid

(2008) Carme Pelegrí et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Inhibition of nucleolar transcription as a trigger for neuronal apoptosis

(2008) Katarzyna Kalita et al.   JOURNAL OF NEUROCHEMISTRY

Activation of an Endogenous Suicide Response after Perturbation of rRNA Synthesis Leads to Neurodegeneration in Mice

(2008) R. Parlato et al.   JOURNAL OF NEUROSCIENCE

Nucleophosmin Serves as a Rate-Limiting Nuclear Export Chaperone for the Mammalian Ribosome

(2008) L. B. Maggi et al.   MOLECULAR AND CELLULAR BIOLOGY

NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells

(2008) W Qi et al.   ONCOGENE

Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival

(2008) S. B. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Npm1 in proliferation, apoptosis and differentiation of neural stem cells

(2007) Yang Qing et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES