Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L

Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings

(2017) Jie Li et al.   Frontiers in Pharmacology

Phase I trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine

(2016) Masafumi Ikeda et al.   CANCER SCIENCE

Arctigenin Confers Neuroprotection Against Mechanical Trauma Injury in Human Neuroblastoma SH-SY5Y Cells by Regulating miRNA-16 and miRNA-199a Expression to Alleviate Inflammation

(2016) Jie Song et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2

(2016) Jie Chen et al.   RESEARCH IN VETERINARY SCIENCE

Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa–induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways

(2016) Yuanyuan Hou et al.   Acta Pharmaceutica Sinica B

Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway

(2015) Xin Wu et al.   BIOCHEMICAL PHARMACOLOGY

Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration

(2015) Xiao-yan Zeng et al.   FITOTERAPIA

Arctigenin suppresses transforming growth factor-β1-induced expression of monocyte chemoattractant protein-1 and the subsequent epithelial–mesenchymal transition through reactive oxygen species-dependent ERK/NF-κB signaling pathway in renal tubular epithelial cells

(2015) A. Li et al.   FREE RADICAL RESEARCH

Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling

(2015) Wen-zhou Zhang et al.   INFLAMMATION

Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin

(2015) Hong Xin et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPK and PPAR-γ/ROR-γt Signaling

(2015) Wen Li et al.   MOLECULAR NEUROBIOLOGY

Elucidation of Arctigenin Pharmacokinetics After Intravenous and Oral Administrations in Rats: Integration of In Vitro and In Vivo Findings via Semi-mechanistic Pharmacokinetic Modeling

(2014) Qiong Gao et al.   AAPS Journal

Observational study of Arctium lappa in the treatment of acne vulgaris

(2014) Anjali Miglani et al.   Homeopathy

Arctigenin Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Rats

(2014) Xianbao Shi et al.   INFLAMMATION

Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice

(2014) Xin Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Arctigenin promotes cholesterol efflux from THP-1 macrophages through PPAR-γ/LXR-α signaling pathway

(2013) Xiaolin Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of an LC/MS/MS method in order to determine arctigenin in rat plasma: its application to a pharmacokinetic study

(2013) Quanfei Zou et al.   BIOMEDICAL CHROMATOGRAPHY

The efficacy and safety of a proposed herbal moisturising cream for dry skin and itch relief: a randomised, double-blind, placebo-controlled trial- study protocol

(2013) Dong-Hyo Lee et al.   BMC Complementary and Alternative Medicine

Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages

(2013) Supriya R. Hyam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC

(2013) Wei Wang et al.   FITOTERAPIA

Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both  -Amyloid Production and Clearance

(2013) Z. Zhu et al.   JOURNAL OF NEUROSCIENCE

Extensive intestinal first-pass metabolism of arctigenin: Evidenced by simultaneous monitoring of both parent drug and its major metabolites

(2013) Qiong Gao et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Visual Data Analysis with Support Vector Machine for the Analysis of Three Processed Aconitum Drugs

(2013) W Gao et al.   PLANTA MEDICA

Identification of Adiponectin Receptor Agonist Utilizing a Fluorescence Polarization Based High Throughput Assay

(2013) Yiyi Sun et al.   PLoS One

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Arctigenin alleviates ER stress via activating AMPK

(2012) Yuan Gu et al.   ACTA PHARMACOLOGICA SINICA

Arctigenin Protects Focal Cerebral Ischemia-Reperfusion Rats through Inhibiting Neuroinflammation

(2012) Tao Fan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists

(2012) Hsiang-Ru Lin   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Arctigenin promotes degradation of inducible nitric oxide synthase through CHIP-associated proteasome pathway and suppresses its enzyme activity

(2012) Xiangyang Yao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pharmacokinetic study of arctigenin in rat plasma and organ tissue by RP-HPLC method

(2012) Fan He et al.   NATURAL PRODUCT RESEARCH

Optimum Yields of Dibenzylbutyrolactone-type Lignans from Cynareae Fruits, During their Ripening, Germination and Enzymatic Hydrolysis Processes, Determined by On-line Chromatographic Methods

(2012) Lilla Szokol-Borsodi et al.   PHYTOCHEMICAL ANALYSIS

Phytochemical Profile and Apoptotic Activity of Onopordum cynarocephalum

(2012) Carmen Formisano et al.   PLANTA MEDICA

Effects of Arctiin on Streptozotocin-Induced Diabetic Retinopathy in Sprague-Dawley Rats

(2012) Lai-chun Lu et al.   PLANTA MEDICA

Antioxidative and in vitro antiproliferative activity of Arctium lappa root extracts

(2011) Fabricia S Predes et al.   BMC Complementary and Alternative Medicine

Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway

(2011) Xianjuan Kou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway

(2011) Xiangyang Yao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Novel PI3K/Akt Inhibitors Screened by the Cytoprotective Function of Human Immunodeficiency Virus Type 1 Tat

(2011) Yuri Kim et al.   PLoS One

Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes

(2011) Wei-Jern Tsai et al.   Chinese Medicine

Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I–IV allergic inflammation and pro-inflammatory enzymes

(2010) Ji Yun Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Dibenzylbutyrolactone Lignans from Forsythia koreana Fruits Attenuate Lipopolysaccharide-Induced Inducible Nitric Oxide Synthetase and Cyclooxygenase-2 Expressions through Activation of Nuclear Factor-κB and Mitogen-Activated Protein Kinase in RAW264.7 Cells

(2010) Ji Yun Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus

(2010) Kyoko Hayashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Human Intestinal Bacterium, Strain END-2 Is Responsible for Demethylation as Well as Lactonization during Plant Lignan Metabolism

(2010) Jong-Sik Jin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Lignans inhibit cell growth via regulation of Wnt/β-catenin signaling

(2010) Ji-Hye Yoo et al.   FOOD AND CHEMICAL TOXICOLOGY

Complementary fragmentation pattern analysis by gas chromatography–mass spectrometry and liquid chromatography tandem mass spectrometry confirmed the precious lignan content of Cirsium weeds

(2010) I. Boldizsár et al.   JOURNAL OF CHROMATOGRAPHY A

Development of antibodies against secoisolariciresinol – Application to the immunolocalization of lignans in Linum usitatissimum seeds

(2010) Jacques Attoumbré et al.   PHYTOCHEMISTRY

Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria

(2010) Bence Csapi et al.   PHYTOTHERAPY RESEARCH

A review of the pharmacological effects of Arctium lappa (burdock)

(2010) Yuk-Shing Chan et al.   INFLAMMOPHARMACOLOGY

In vitro estrogenic activity of Asplenium trichomanes L. extracts and isolated compounds

(2009) Stefano Dall’Acqua et al.   JOURNAL OF ETHNOPHARMACOLOGY

In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway

(2009) Feng Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats

(2009) Jian-Guo Wu et al.   PHYTOMEDICINE

Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan

(2008) V. Swarup et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Anti-inflammatory activity of arctigenin from Forsythiae Fructus

(2007) Hyo Sook Kang et al.   JOURNAL OF ETHNOPHARMACOLOGY