Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 10, Pages 903-906Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.666745
Keywords
pharmacokinetics; distribution; arctigenin; HPLC
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Funding
- National Eleventh-five-year Plan in R&D of Important New Medicine [2009ZX09103-423]
- Supporting Plan Project for Excellent Researcher of Liaoning Provincial Education Department [2008RC34]
- Scientific and Technical Bureau of Shenyang [F11-264-1-20]
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A high-performance liquid chromatography (HPLC) technique was developed for the determination of arctigenin in plasma and various organs of rats after the oral administration of 30, 50 and 70mgkg(-1) of arctigenin to the Sprague-Dawley rats. Results showed that the validated HPLC method was simple, fast, reproducible and suitable to the determination of arctigenin in rat plasma and organ tissue and one-compartmental model with zero-order absorption process can well describe the changes of arctigenin concentration in the plasma. The concentration of compound was highest in the spleen, less in the liver and the least in the lung.
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