High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis

Application of RNAi to Genomic Drug Target Validation in Schistosomes

(2015) Alessandra Guidi et al.   PLoS Neglected Tropical Diseases

Decades down the line: the viability of praziquantel for future schistosomiasis treatment

(2012) Donato Cioli et al.   Expert Review of Anti-Infective Therapy

Identification of Thioredoxin Glutathione Reductase Inhibitors That Kill Cestode and Trematode Parasites

(2012) Fabiana Ross et al.   PLoS One

Praziquantel and Schistosomiasis

(2010) Alexander Dömling et al.   ChemMedChem

Phenylsulfonylfuroxans as Modulators of Multidrug-Resistance-Associated Protein-1 and P-Glycoprotein

(2010) Roberta Fruttero et al.   JOURNAL OF MEDICINAL CHEMISTRY

Africa is desperate for praziquantel

(2010) Peter J Hotez et al.   LANCET

RNA Interference in Schistosoma mansoni Schistosomula: Selectivity, Sensitivity and Operation for Larger-Scale Screening

(2010) Saša Štefanić et al.   PLoS Neglected Tropical Diseases

Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis

(2009) Ganesha Rai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Schistosomiasis in Africa: An Emerging Tragedy in Our New Global Health Decade

(2009) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

A 1,536-Well-Based Kinetic HTS Assay for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase

(2008) Wendy A. Lea et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

(2008) Ahmed A Sayed et al.   NATURE MEDICINE

Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

(2008) Anton Simeonov et al.   PLoS Neglected Tropical Diseases