Plant-Derived Compounds Targeting Pancreatic Beta Cells for the Treatment of Diabetes

50 years forward: mechanisms of hyperglycaemia-driven diabetic complications

(2015) Nicholas D. F. Russell et al.   DIABETOLOGIA

Bidens pilosaFormulation Improves Blood Homeostasis andβ-Cell Function in Men: A Pilot Study

(2015) Bun-Yueh Lai et al.   Evidence-based Complementary and Alternative Medicine

Anti-apoptotic Function and Mechanism of Ginseng Saponins in Rattus Pancreatic β-Cells

(2015) Fang Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Silymarin Inhibits Cytokine-Stimulated Pancreatic Beta Cells by Blocking the ERK1/2 Pathway

(2014) Eun Jeong Kim et al.   Biomolecules & Therapeutics

Silymarin Induces Expression of Pancreatic Nkx6.1 Transcription Factor and β-Cells Neogenesis in a Pancreatectomy Model

(2014) Claudia Soto et al.   MOLECULES

Economic Costs of Diabetes in the U.S. in 2012

(2013)   DIABETES CARE

Antidiabetic Effect and Mode of Action of Cytopiloyne

(2013) Cicero Lee-Tian Chang et al.   Evidence-based Complementary and Alternative Medicine

Bidens pilosaL. (Asteraceae): Botanical Properties, Traditional Uses, Phytochemistry, and Pharmacology

(2013) Arlene P. Bartolome et al.   Evidence-based Complementary and Alternative Medicine

Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats

(2012) Isela Esther Juárez-Rojop et al.   BMC Complementary and Alternative Medicine

Curcumin Extract for Prevention of Type 2 Diabetes

(2012) S. Chuengsamarn et al.   DIABETES CARE

Investigation of intracellular signalling cascades mediating stimulatory effect of aGymnema sylvestreextract on insulin secretion from isolated mouse and human islets of Langerhans

(2012) A. Al-Romaiyan et al.   DIABETES OBESITY & METABOLISM

Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis

(2012) Hui Dong et al.   Evidence-based Complementary and Alternative Medicine

Hypoglycemic Activity of Gymnema sylvestre Extracts on Oxidative Stress and Antioxidant Status in Diabetic Rats

(2012) Myung-Hwa Kang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of physiological quercetin metabolites on interleukin-1β-induced inducible NOS expression

(2012) Jae Min Cho et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance

(2012) Jill P. Crandall et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

(2012) Jayesh Kumar Bhatt et al.   NUTRITION RESEARCH

A Novel Extract ofGymnema sylvestreImproves Glucose ToleranceIn Vivoand Stimulates Insulin Secretion and SynthesisIn Vitro

(2012) A. Al-Romaiyan et al.   PHYTOTHERAPY RESEARCH

Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic β-cell function

(2012) Elizabeth. R. Gilbert et al.   Food & Function

Increase in Insulin Secretion Induced by Panax ginseng Berry Extracts Contributes to the Amelioration of Hyperglycemia in Streptozotocin-induced Diabetic Mice

(2012) Eun-Young Park et al.   Journal of Ginseng Research

Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials

(2011) Sina Kim et al.   Chinese Journal of Integrative Medicine

Conophylline Suppresses Pancreatic Stellate Cells and Improves Islet Fibrosis in Goto-Kakizaki Rats

(2011) Rie Saito et al.   ENDOCRINOLOGY

The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids

(2011) Mohamed A. El-Moselhy et al.   FOOD AND CHEMICAL TOXICOLOGY

Antihyperglycaemic effects of ethanol extracts ofCarica papayaandPandanus amaryfolliusleaf in streptozotocin-induced diabetic mice

(2011) Sreenivasan Sasidharan et al.   NATURAL PRODUCT RESEARCH

Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus

(2011) Ji-Hye Kim et al.   Nutrition Research and Practice

Promotion of β-cell differentiation by the alkaloid conophylline in porcine pancreatic endocrine cells

(2010) M. Kawakami et al.   BIOMEDICINE & PHARMACOTHERAPY

Quercetin potentiates insulin secretion and protects INS-1 pancreatic β-cells against oxidative damage via the ERK1/2 pathway

(2010) E Youl et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice

(2010) Zhuo Fu et al.   ENDOCRINOLOGY

Berberine: a potential phytochemical with multispectrum therapeutic activities

(2010) Parameswara Rao Vuddanda et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation

(2010) David G. I. Kingston   JOURNAL OF NATURAL PRODUCTS

Curcumin improves insulin resistance in skeletal muscle of rats

(2010) L.-X. Na et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate β-cells regeneration and anti-diabetic activity in Wistar rats

(2010) A. Bakrudeen Ali Ahmed et al.   PHYTOMEDICINE

A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro

(2010) A. Al-Romaiyan et al.   PHYTOTHERAPY RESEARCH

Partial regeneration of β-cells in the islets of Langerhans by Nymphayol a sterol isolated from Nymphaea stellata (Willd.) flowers

(2009) P. Subash-Babu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Prooxidative effects of green tea polyphenol (−)-epigallocatethin-3-gallate on the HIT-T15 pancreatic beta cell line

(2009) Kwang Sik Suh et al.   CELL BIOLOGY AND TOXICOLOGY

Characterisation of the Insulinotropic Activity of an Aqueous Extract of Gymnema Sylvestre in Mouse β-Cells and Human Islets of Langerhans

(2009) Bo Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Administration of Conophylline and Betacellulin-δ4 Increases the β-cell Mass in Neonatal Streptozotocin-treated Rats

(2009) Tsutomu KODERA et al.   ENDOCRINE JOURNAL

Epigallocatechin Gallate (EGCG) and Rutin Suppress the Glucotoxicity through Activating IRS2 and AMPK Signaling in Rat Pancreatic β Cells

(2009) Erica P. Cai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats

(2009) Pitchai Daisy et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 CellsviaPKA-Dependent Pathways

(2008) Sunmin PARK et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Overexpression of SIRT1 Protects Pancreatic  -Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor- B Signaling Pathway

(2008) J.-H. Lee et al.   DIABETES

Berberine Acutely Inhibits Insulin Secretion from β-Cells through 3′,5′-Cyclic Adenosine 5′-Monophosphate Signaling Pathway

(2008) Libin Zhou et al.   ENDOCRINOLOGY

Dietary Supplements in the Management of Diabetes: Potential Risks and Benefits

(2008) Patti Geil et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Efficacy of berberine in patients with type 2 diabetes mellitus

(2008) Jun Yin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hypoglycemic and Antihyperglycemic Activity of Nymphaea stellata Flowers in Normal and Alloxan Diabetic Rats

(2008) K. Rajagopal et al.   PHARMACEUTICAL BIOLOGY

Dietary red chilli (Capsicum frutescens L.) is insulinotropic rather than hypoglycemic in type 2 diabetes model of rats

(2008) Md. Shahidul Islam et al.   PHYTOTHERAPY RESEARCH

Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: Results of a randomized, double-blind, placebo-controlled study of efficacy and safety

(2006) Vladimir Vuksan et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES