Article
Cell Biology
Diletta Overi, Guido Carpino, Marta Moretti, Antonio Franchitto, Lorenzo Nevi, Paolo Onori, Enrico De Smaele, Luca Federici, Daniele Santorelli, Marella Maroder, Lola M. Reid, Vincenzo Cardinale, Domenico Alvaro, Eugenio Gaudio
Summary: There is contrasting evidence on the contribution of stem/progenitor cell populations to pancreatic regeneration in diabetes, however, the PDG compartment may play a role in this process. T2DM patients show signs of pancreatic islet regeneration and involvement of the PDG niche, and PDX1 administration could support increased endocrine pancreatic regeneration in experimental diabetes. These findings contribute to defining the role and participation of stem/progenitor cell compartments within the pancreas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Butian Wei, Xin Zhang, Jiwei Qian, Zhe Tang, Bo Zhang
Summary: Nrf2 is an important intracellular regulator of antioxidant stress, regulating not only antioxidant function but also insulin secretion, proliferation, and differentiation of beta cells, ER stress, and mitochondrial function. Pharmacological activation of Nrf2 has been shown to protect islet cells during different stages of transplantation in experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Roi Anteby, Aaron Lucander, Piotr J. Bachul, Jordan Pyda, Damian Grybowski, Lindsay Basto, Gabriela S. Generette, Laurencia Perea, Karolina Golab, Ling-jia Wang, Martin Tibudan, Celeste Thomas, John Fung, Piotr Witkowski
Summary: This study evaluated the prognostic utility of monitoring islet autoantibodies in diabetic patients after islet transplantation. It was found that GAD antibody levels could potentially serve as a predictive marker for outcomes post-transplant, while IA-2A and ZnT8A were undetectable in all patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Martha Campbell-Thompson, Elizabeth A. Butterworth, J. Lucas Boatwright, Malavika A. Nair, Lith H. Nasif, Kamal Nasif, Andy Y. Revell, Alberto Riva, Clayton E. Mathews, Ivan C. Gerling, Desmond A. Schatz, Mark A. Atkinson
Summary: The dysregulation of glucagon secretion in type 1 diabetes involves the sympathetic nervous system and noradrenalin degradation pathways. The study found that sympathetic innervation at islets and intrinsic adrenergic signaling pathways could be novel targets for improving glucagon secretion in T1D patients.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, Emma Vanderleeden, Melanie I. Trombly, Christina E. Baer, David M. Harlan, Dale L. Greiner, Manuel Garber, Jennifer P. Wang
Summary: This article explores the early cellular processes of autoimmune type 1 diabetes in rats, and identifies the stress response of beta- and alpha-cells as well as their association with immune cells. These findings provide insights for the development of therapeutic and prevention strategies for T1D.
Article
Biochemistry & Molecular Biology
Sarah Duin, Shreya Bhandarkar, Susann Lehmann, Elisabeth Kemter, Eckhard Wolf, Michael Gelinsky, Barbara Ludwig, Anja Lode
Summary: The transplantation of pancreatic islets can prevent complications in diabetes patients. 3D bioprinting can encapsulate islets and improve the success rate of transplantation. This study successfully bioprinted neonatal porcine islet-like cell clusters and demonstrated their functionality in vitro.
Article
Medicine, Research & Experimental
Katharina Warncke, Andreas Weiss, Peter Achenbach, Thekla von dem Berge, Reinhard Berner, Kristina Casteels, Lidia Groele, Konstantinos Hatzikotoulas, Angela Hommel, Olga Kordonouri, Helena Elding Larsson, Markus Lundgren, Benjamin A. Marcus, Matthew D. Snape, Agnieszka Szypowska, John A. Todd, Ezio Bonifacio, Anette-G. Ziegler
Summary: The etiology of type 1 diabetes involves autoimmune responses against pancreatic beta cells. This study found heterogeneity in blood glucose control in children with high genetic risk of type 1 diabetes and suggested that islet autoimmunity occurs concurrently or subsequent to insults on the pancreatic islets.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Sayaka Sawada, Chika Miyagi-Shiohira, Kazuho Kuwae, Yoshihito Tamaki, Kai Nishime, Mayuko Sakai-Yonaha, Tasuku Yonaha, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi
Summary: The study found that adding amphotericin B to the preservation solution deteriorates islet yield during porcine islet isolation, and it is also cytotoxic to porcine islets and acinar tissue.
XENOTRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Glenn M. Ward, Jacqueline M. Walters, Judith L. Gooley, Raymond C. Boston
Summary: The authors discuss modifications made to glucose challenge protocols and mathematical models in order to estimate insulin secretion, insulin sensitivity, and glucose effectiveness in patients with Insulin-Requiring Diabetes and those who received Pancreatic Islet Transplants for Type I diabetes. The evolution of protocols and models for use in Type I Diabetes and Insulin-Requiring Type 2 Diabetes that were the basis for studies in Islet Recipients is outlined. The ongoing application of adaptations is helping to clarify Islet pathophysiology in Islet Transplant Recipients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
J. Cantley, D. L. Eizirik, E. Latres, C. M. Dayan
Summary: This article provides an overview of the main themes discussed at the JDRF-DiabetesUK-INNODIA-nPOD symposium in Stockholm, Sweden, highlighting promising conclusions and key unmet needs in achieving better approaches to prevent or reverse T1D.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Marluce da Cunha Mantovani, Ilana Gabanyi, Carlos Andres Pantanali, Vinicius Rocha Santos, Maria Lucia Cardillo Correa-Giannella, Mari Cleide Sogayar
Summary: Background: Type 1 diabetes mellitus (T1D) is a condition caused by autoimmune destruction of pancreatic beta cells. Transplantation of isolated pancreatic islets from donors is a potential treatment for T1D, but the limited availability of suitable pancreas donors is a major challenge. Methods: A retrospective study was conducted to analyze the profile of brain-dead human pancreas donors and the reasons for organ refusal. Results: The main reasons for refusal were hyperglycemia, technical issues, age, positive serology, and hyperamylasemia. Conclusions: This study provides insights to improve the availability of suitable pancreas donors and enhance the outcome of islet isolation and transplantation.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Review
Food Science & Technology
Yang Liu, Qianwen Wang, Kangze Wu, Zhouyi Sun, Zhe Tang, Xian Li, Bo Zhang
Summary: The incidence of diabetes mellitus is increasing every year, causing a global burden. Existing treatments have limitations, and new approaches are needed. Anthocyanins have positive effects on diabetes, reducing the risk and improving metabolism and antioxidant activity. They also improve the damage and function of pancreatic islets after transplantation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Endocrinology & Metabolism
Diego Balboa, Diepiriye G. Iworima, Timothy J. Kieffer
Summary: The review discusses the recent progress in generating and characterizing functional stem cell-derived beta cells, as well as the possibilities and challenges in diabetes disease modeling using stem cells.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Review
Endocrinology & Metabolism
D. Walker Hagan, Sandra M. M. Ferreira, Gustavo J. J. Santos, Edward A. A. Phelps
Summary: GABA, a neurotransmitter produced in the islet, influences the activity of islet cells through multiple receptors and interacts with cellular metabolism. Loss or reduction of GABA in diabetic individuals may contribute to disease pathogenesis and dysfunction of islet cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)