Modeling Myeloid Malignancies Using Zebrafish

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

(2017) Kiyohiro Ando et al.   JOURNAL OF CELL BIOLOGY

Genome editing using CRISPR/Cas9-based knock-in approaches in zebrafish

(2017) Shahad Albadri et al.   METHODS

SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast

(2017) Tucker J. Carrocci et al.   NUCLEIC ACIDS RESEARCH

Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells

(2017) Tuoen Liu et al.   PLoS One

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

(2016) Esther A. Obeng et al.   CANCER CELL

Spliceosomal component Sf3b1 is essential for hematopoietic differentiation in zebrafish

(2016) Adriana De La Garza et al.   EXPERIMENTAL HEMATOLOGY

SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing

(2016) Qing Tang et al.   GENES & DEVELOPMENT

Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish

(2016) Finola E. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure

(2016) Jason Ear et al.   Journal of Genetics and Genomics

Overexpression of FLT3-ITD driven by spi-1 results in expanded myelopoiesis with leukemic phenotype in zebrafish

(2016) J-W Lu et al.   LEUKEMIA

Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts

(2016) A Mupo et al.   LEUKEMIA

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development

(2016) Jonathan Henninger et al.   NATURE CELL BIOLOGY

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

(2016) Andrew P. Feinberg et al.   NATURE REVIEWS GENETICS

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

(2016) C. K. Kaufman et al.   SCIENCE

Zebrafish Genome Engineering Using the CRISPR–Cas9 System

(2016) Mingyu Li et al.   TRENDS IN GENETICS

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

(2016) Samar Alsafadi et al.   Nature Communications

‘Acute myeloid leukemia: a comprehensive review and 2016 update’

(2016) I De Kouchkovsky et al.   Blood Cancer Journal

Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development

(2016) Elisa Barbieri et al.   Oncotarget

Active recombinant Tol2 transposase for gene transfer and gene discovery applications

(2016) Jun Ni et al.   Mobile DNA

RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1

(2015) J. Ear et al.   BLOOD

Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish

(2015) X. Shi et al.   BLOOD

A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish

(2015) Julien Ablain et al.   DEVELOPMENTAL CELL

Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98–HOXA9-induced myeloid disease

(2015) A P Deveau et al.   LEUKEMIA

Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence

(2015) Cheng Li et al.   Cell Reports

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

(2015) Rachel B. Darman et al.   Cell Reports

Incidence and Burden of the Myelodysplastic Syndromes

(2015) Christopher R. Cogle   Current Hematologic Malignancy Reports

Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers

(2015) Christopher DeBoever et al.   PLoS Computational Biology

Myelodysplastic syndromes in the United States: an update for clinicians

(2014) Jesse D. Troy et al.   ANNALS OF MEDICINE

L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way

(2014) Anupama Narla et al.   BRITISH JOURNAL OF HAEMATOLOGY

Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes

(2014) GanLin He et al.   Cancer Cell International

Zebrafish as a model to assess cancer heterogeneity, progression and relapse

(2014) J. S. Blackburn et al.   Disease Models & Mechanisms

U2AF1mutations alter splice site recognition in hematological malignancies

(2014) Janine O. Ilagan et al.   GENOME RESEARCH

Human Flt3 Is Expressed at the Hematopoietic Stem Cell and the Granulocyte/Macrophage Progenitor Stages to Maintain Cell Survival

(2014) Y. Kikushige et al.   JOURNAL OF IMMUNOLOGY

SF3B1mutations constitute a novel therapeutic target in breast cancer

(2014) Sarah L Maguire et al.   JOURNAL OF PATHOLOGY

PRPF8 defects cause missplicing in myeloid malignancies

(2014) A Kurtovic-Kozaric et al.   LEUKEMIA

Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients

(2014) R Kihara et al.   LEUKEMIA

A Zebrafish Model of Myelodysplastic Syndrome Produced throughtet2Genomic Editing

(2014) Evisa Gjini et al.   MOLECULAR AND CELLULAR BIOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Critical Role of Jak2 in the Maintenance and Function of Adult Hematopoietic Stem Cells

(2014) Hajime Akada et al.   STEM CELLS

Initial experience with L-leucine therapy in myelodysplastic syndromes with associated chromosome 5q deletion

(2013) D. P. Steensma et al.   BLOOD

Clinical and biological implications of driver mutations in myelodysplastic syndromes

(2013) E. Papaemmanuil et al.   BLOOD

Erythro-myeloid progenitors: “Definitive” hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells

(2013) Jenna M. Frame et al.   BLOOD CELLS MOLECULES AND DISEASES

In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation

(2013) Maria-Cristina Keightley et al.   FEBS LETTERS

FLT3-ITD confers poor prognosis in patients with acute promyelocytic leukemia treated with AIDA protocols: long-term follow-up analysis

(2013) M. Breccia et al.   HAEMATOLOGICA

Mutational analysis of splicing machinery genesSF3B1, U2AF1andSRSF2in myelodysplasia and other common tumors

(2013) Eun Mi Je et al.   INTERNATIONAL JOURNAL OF CANCER

Acquired Mutations That Affect Pre-mRNA Splicing in Hematologic Malignancies and Solid Tumors

(2013) L. M. Scott et al.   JNCI-Journal of the National Cancer Institute

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

(2013) T Haferlach et al.   LEUKEMIA

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma

(2013) J William Harbour et al.   NATURE GENETICS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptome Analysis of the Zebrafish Model of Diamond-Blackfan Anemia from RPS19 Deficiency via p53-Dependent and -Independent Pathways

(2013) Qiong Jia et al.   PLoS One

SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma

(2013) S. J. Furney et al.   Cancer Discovery

Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms

(2012) M. Cazzola et al.   BLOOD

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

(2012) H. Makishima et al.   BLOOD

L-leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway

(2012) E. M. Payne et al.   BLOOD

Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR

(2012) Jared J. Ganis et al.   DEVELOPMENTAL BIOLOGY

Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafish

(2012) S. M. N. Onnebo et al.   HAEMATOLOGICA

Whole-genome analysis informs breast cancer response to aromatase inhibition

(2012) Matthew J. Ellis et al.   NATURE

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

(2011) L. Malcovati et al.   BLOOD

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

(2011) D. Rossi et al.   BLOOD

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

(2011) Z. Li et al.   BLOOD

NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis

(2011) A. Michael Forrester et al.   BRITISH JOURNAL OF HAEMATOLOGY

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy

(2011) B. Pruvot et al.   HAEMATOLOGICA

RUNX1 Mutations in Acute Myeloid Leukemia: Results From a Comprehensive Genetic and Clinical Analysis From the AML Study Group

(2011) Verena I. Gaidzik et al.   JOURNAL OF CLINICAL ONCOLOGY

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

(2011) Timothy A Graubert et al.   NATURE GENETICS

Spliceosome mutations in hematopoietic malignancies

(2011) Christopher N Hahn et al.   NATURE GENETICS

SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

(2011) E. Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

AML1/RUNX1 gene point mutations in childhood myeloid malignancies

(2011) Alexandr Migas et al.   PEDIATRIC BLOOD & CANCER

p53 Upregulation Is a Frequent Response to Deficiency of Cell-Essential Genes

(2011) Nadia Danilova et al.   PLoS One

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia

(2010) A. C. H. Smith et al.   BLOOD

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish

(2010) N. Bolli et al.   BLOOD

Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants

(2010) K. M. Balla et al.   BLOOD

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

(2010) Stefan Gross et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

MYST family histone acetyltransferases take center stage in stem cells and development

(2009) Anne K. Voss et al.   BIOESSAYS

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

(2009) P. P. Zarrinkar et al.   BLOOD

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

(2009) H. Dohner et al.   BLOOD

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer

(2009) B L Ebert   LEUKEMIA

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

(2009) Jing-Ruey J Yeh et al.   Nature Chemical Biology

MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

(2008) Julia Zhuravleva et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis

(2008) J. Y. Bertrand et al.   DEVELOPMENT

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE