Regulation of mTOR, Metabolic Fitness, and Effector Functions by Cytokines in Natural Killer Cells
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Regulation of mTOR, Metabolic Fitness, and Effector Functions by Cytokines in Natural Killer Cells
Authors
Keywords
-
Journal
Cancers
Volume 9, Issue 12, Pages 132
Publisher
MDPI AG
Online
2017-09-28
DOI
10.3390/cancers9100132
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
- (2017) Hyungseok Seo et al. Nature Communications
- Transforming growth factor-β: A therapeutic target for cancer
- (2017) Sulsal Haque et al. Human Vaccines & Immunotherapeutics
- High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors
- (2017) Antoine Marçais et al. eLife
- IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56 bright NK Cells and Increases NK-Cell Cytokine Release Capabilities
- (2017) Sigrid Dubois et al. Cancer Immunology Research
- NK Cell Exhaustion
- (2017) Jiacheng Bi et al. Frontiers in Immunology
- What Fuels Natural Killers? Metabolism and NK Cell Responses
- (2017) Clair M. Gardiner et al. Frontiers in Immunology
- IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells
- (2016) Y. Mao et al. BLOOD
- Stimulation of Natural Killer Cell–Mediated Tumor Immunity by an IL15/TGFβ–Neutralizing Fusion Protein
- (2016) Spencer Ng et al. CANCER RESEARCH
- A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells
- (2016) Meromit Singer et al. CELL
- IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function
- (2016) D. A. Vallera et al. CLINICAL CANCER RESEARCH
- Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with Myeloma
- (2016) M. Carlsten et al. CLINICAL CANCER RESEARCH
- The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
- (2016) Nicole E. Scharping et al. IMMUNITY
- Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
- (2016) Bertram Bengsch et al. IMMUNITY
- MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade
- (2016) Peter J.R. Ebert et al. IMMUNITY
- A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody Demonstrates Antigen-specific Antitumor Responses
- (2016) Bai Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies
- (2016) Annette Romanski et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Metabolic Reprogramming Supports IFN-γ Production by CD56brightNK Cells
- (2016) Sinéad E. Keating et al. JOURNAL OF IMMUNOLOGY
- CIS is a potent checkpoint in NK cell–mediated tumor immunity
- (2016) Rebecca B Delconte et al. NATURE IMMUNOLOGY
- Phosphatase PP2A is requisite for the function of regulatory T cells
- (2016) Sokratis A Apostolidis et al. NATURE IMMUNOLOGY
- Targeting natural killer cells in cancer immunotherapy
- (2016) Camille Guillerey et al. NATURE IMMUNOLOGY
- TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
- (2016) Sébastien Viel et al. Science Signaling
- Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia
- (2016) Rizwan Romee et al. Science Translational Medicine
- Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host
- (2016) Anna Schurich et al. Cell Reports
- TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
- (2016) Sébastien Viel et al. Science Signaling
- Phenotypic and Functional Dysregulated Blood NK Cells in Colorectal Cancer Patients Can Be Activated by Cetuximab Plus IL-2 or IL-15
- (2016) Yamila Sol Rocca et al. Frontiers in Immunology
- Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds
- (2015) K. Lagrue et al. BLOOD
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory
- (2015) Timothy E. O’Sullivan et al. IMMUNITY
- Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer
- (2015) Kevin C. Conlon et al. JOURNAL OF CLINICAL ONCOLOGY
- Activation-Specific Metabolic Requirements for NK Cell IFN-γ Production
- (2015) Molly P. Keppel et al. JOURNAL OF IMMUNOLOGY
- Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor
- (2015) Kurt Schönfeld et al. MOLECULAR THERAPY
- The cytotoxic T cell proteome and its shaping by the kinase mTOR
- (2015) Jens L Hukelmann et al. NATURE IMMUNOLOGY
- T cell metabolic fitness in antitumor immunity
- (2015) Peter J. Siska et al. TRENDS IN IMMUNOLOGY
- PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
- (2015) Nikolaos Patsoukis et al. Nature Communications
- Cytokine therapy reverses NK cell anergy in MHC-deficient tumors
- (2014) Michele Ardolino et al. JOURNAL OF CLINICAL INVESTIGATION
- TGF- Utilizes SMAD3 to Inhibit CD16-Mediated IFN- Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells
- (2014) R. Trotta et al. JOURNAL OF IMMUNOLOGY
- mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function
- (2014) Raymond P. Donnelly et al. JOURNAL OF IMMUNOLOGY
- The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
- (2014) Antoine Marçais et al. NATURE IMMUNOLOGY
- NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response
- (2014) Anne L. Ruiz et al. Nature Communications
- TGF-β Activation and Function in Immunity
- (2013) Mark A. Travis et al. Annual Review of Immunology
- Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies
- (2013) H. E. Kohrt et al. BLOOD
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- Targeting Natural Killer Cells to Acute Myeloid Leukemia In Vitro with a CD16 x 33 Bispecific Killer Cell Engager and ADAM17 Inhibition
- (2013) A. Wiernik et al. CLINICAL CANCER RESEARCH
- mTOR and lymphocyte metabolism
- (2013) Hu Zeng et al. CURRENT OPINION IN IMMUNOLOGY
- The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells
- (2013) J-S Delisle et al. GENES AND IMMUNITY
- Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
- (2013) Laura A. Sena et al. IMMUNITY
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors
- (2012) Jing Ni et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy
- (2012) Jason Park et al. NATURE MATERIALS
- IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
- (2011) D. M. Benson et al. BLOOD
- Fk506 Binding Protein 12 Deficiency in Endothelial and Hematopoietic Cells Decreases Regulatory T Cells and Causes Hypertension
- (2011) Valorie L. Chiasson et al. HYPERTENSION
- Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity
- (2011) Emilie Mamessier et al. JOURNAL OF CLINICAL INVESTIGATION
- The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
- (2010) D. M. Benson et al. BLOOD
- The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism
- (2010) Jonathan D. Powell et al. IMMUNITY
- Serine/Threonine Phosphatases: Mechanism through Structure
- (2009) Yigong Shi CELL
- Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo
- (2009) C. Sola et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functions of natural killer cells
- (2008) Eric Vivier et al. NATURE IMMUNOLOGY
- T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
- (2008) S. Sauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More