Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma

Binimetinib versus dacarbazine in patients with advanced NRAS -mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial

(2017) Reinhard Dummer et al.   LANCET ONCOLOGY

Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma

(2016) G. Carita et al.   EUROPEAN JOURNAL OF CANCER

TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway

(2016) Guohe Song et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancer

(2016) Guangcun Cheng et al.   Molecular Cancer

Dual PI3K/mTOR Inhibition in Colorectal Cancers withAPCandPIK3CAMutations

(2016) Tyler M. Foley et al.   MOLECULAR CANCER RESEARCH

PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets

(2015) M. Scortegagna et al.   CANCER RESEARCH

Protein kinase C in the immune system: from signalling to chromatin regulation

(2015) Pek Siew Lim et al.   IMMUNOLOGY

PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model

(2015) J Du et al.   ONCOGENE

TIMP-1 activated carcinoma-associated fibroblasts inhibit tumor apoptosis by activating SDF1/CXCR4 signaling in hepatocellular carcinoma

(2015) Tao Song et al.   Oncotarget

Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets

(2015) Giuseppe Palmieri et al.   Frontiers in Oncology

TIMP-1 via TWIST1 Induces EMT Phenotypes in Human Breast Epithelial Cells

(2014) R. C. D'Angelo et al.   MOLECULAR CANCER RESEARCH

Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation

(2014) Kuntal Halder et al.   PLoS One

Tissue Inhibitor of Metalloproteinase 1 Expression Associated with Gene Demethylation Confers Anoikis Resistance in Early Phases of Melanocyte Malignant Transformation

(2014) Tatiana I. Ricca et al.   Translational Oncology

Protein Kinase C -Calcineurin Cosignaling Downstream of Toll-Like Receptor 4 Downregulates Fibrosis and Induces Wound Healing Gene Expression in Cardiac Myofibroblasts

(2013) R. F. D. S. Mesquita et al.   MOLECULAR AND CELLULAR BIOLOGY

Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation

(2013) Mariana Toricelli et al.   Molecular Cancer

Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf V600E ::Pten –/– melanoma

(2013) M Scortegagna et al.   ONCOGENE

TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression

(2013) Christina Bjerre et al.   TUMOR BIOLOGY

Specifying protein kinase C functions in melanoma

(2012) Mitchell F. Denning   Pigment Cell & Melanoma Research

Targeting PDK1 in Cancer

(2011) C. Raimondi et al.   CURRENT MEDICINAL CHEMISTRY

VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells

(2011) M. M. Bekhite et al.   JOURNAL OF CELL SCIENCE

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

(2009) Krishna M. Vasudevan et al.   CANCER CELL

PIKKing on PKB: regulation of PKB activity by phosphorylation

(2009) Lana Bozulic et al.   CURRENT OPINION IN CELL BIOLOGY

c-Jun Regulates Phosphoinositide-dependent Kinase 1 Transcription

(2009) Pablo Lopez-Bergami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer Targets

(2009) Elizabeth Iorns et al.   PLoS One

New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

(2008) Christian Peifer et al.   BIOCHEMICAL JOURNAL

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL

Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities

(2008) W. G. Stetler-Stevenson   Science Signaling