Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf V600E ::Pten –/– melanoma

3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner

(2015) Paolo Armando Gagliardi et al.   NEOPLASIA

The 16p13.3 (PDPK1) Genomic Gain in Prostate Cancer: A Potential Role in Disease Progression

(2014) Khalil A. Choucair et al.   Translational Oncology

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

(2013) Stefan Eser et al.   CANCER CELL

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors

(2012) Ayaz Najafov et al.   BIOCHEMICAL JOURNAL

Melanoma: from mutations to medicine

(2012) H. Tsao et al.   GENES & DEVELOPMENT

Mechanisms of intrinsic and acquired resistance to kinase-targeted therapies

(2012) Shubha Bagrodia et al.   Pigment Cell & Melanoma Research

PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models

(2011) K. Ellwood-Yen et al.   CANCER RESEARCH

Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors

(2011) Jesús R. Medina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

(2010) Ayaz Najafov et al.   BIOCHEMICAL JOURNAL

Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells

(2010) Kumiko Nagashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimizing the noise versus bias trade-off for Illumina whole genome expression BeadChips

(2010) Wei Shi et al.   NUCLEIC ACIDS RESEARCH

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

(2010) B. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

(2009) Krishna M. Vasudevan et al.   CANCER CELL

3-Phosphoinositide-Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma

(2009) M. Maurer et al.   CANCER RESEARCH

Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma

(2009) S. A. Aziz et al.   CLINICAL CANCER RESEARCH

c-Jun Regulates Phosphoinositide-dependent Kinase 1 Transcription

(2009) Pablo Lopez-Bergami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

(2009) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Genomic alterations in lung adenocarcinomas detected by multicolor fluorescence in situ hybridization and comparative genomic hybridization

(2008) Hua Shen et al.   CANCER GENETICS AND CYTOGENETICS

Cracking the system: melanoma complexity demands new therapeutic approaches

(2008) Adina Vultur et al.   Pigment Cell & Melanoma Research