HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance
Authors
Keywords
-
Journal
Cancers
Volume 9, Issue 12, Pages 40
Publisher
MDPI AG
Online
2017-04-27
DOI
10.3390/cancers9050040
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer
- (2017) Sara Duhachek-Muggy et al. Molecular Cancer
- Epithelial-mesenchymal transition in patients with HER2+ metastatic breast cancer.
- (2017) A. Giordano et al. JOURNAL OF CLINICAL ONCOLOGY
- Inhibition of Sonic Hedgehog Signaling Pathway by Thiazole Antibiotic Thiostrepton Attenuates the CD44+/CD24-Stem-Like Population and Sphere-Forming Capacity in Triple-Negative Breast Cancer
- (2016) Na Yang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Tunicamycin-induced endoplasmic reticulum stress reduces in vitro subpopulation and invasion of CD44+/CD24- phenotype breast cancer stem cells
- (2016) Babak Nami et al. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
- The Hedgehog signaling pathway is associated with poor prognosis in breast cancer patients with the CD44+/CD24− phenotype
- (2016) Haishan Zhao et al. Molecular Medicine Reports
- Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying γ-secretase Inhibitors
- (2016) Veronika Mamaeva et al. MOLECULAR THERAPY
- Lapatinib-resistant cancer cells possessing epithelial cancer stem cell properties develop sensitivity during sphere formation by activation of the ErbB/AKT/cyclin D2 pathway
- (2016) Yuichi Ohnishi et al. ONCOLOGY REPORTS
- COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis
- (2016) Mousumi Majumder et al. STEM CELLS
- The efficiency and safety of trastuzumab and lapatinib added to neoadjuvant chemotherapy in Her2-positive breast cancer patients: a randomized meta-analysis
- (2016) Zhe-Ling Chen et al. OncoTargets and Therapy
- In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors
- (2016) Monica Benvenuto et al. Oncotarget
- Aldehyde dehydrogenase 1A1 in stem cells and cancer
- (2016) Hiroyuki Tomita et al. Oncotarget
- Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
- (2016) Rae-Kwon Kim et al. Oncotarget
- Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells
- (2016) Mingjuan Sun et al. Cell and Bioscience
- Cancer Stem Cell Plasticity Drives Therapeutic Resistance
- (2016) Mary Doherty et al. Cancers
- ADAM10: a new player in breast cancer progression?
- (2015) Maeve Mullooly et al. BRITISH JOURNAL OF CANCER
- Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells
- (2015) F Caiazza et al. BRITISH JOURNAL OF CANCER
- Diverse Targets of -Catenin during the Epithelial-Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse
- (2015) Y.-W. Chang et al. CANCER RESEARCH
- ErbB2 signaling activates the Hedgehog pathway via PI3K–Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts
- (2015) Maxim Kebenko et al. CELLULAR SIGNALLING
- Salinomycin exerts anticancer effects on human breast carcinoma MCF-7 cancer stem cells via modulation of Hedgehog signaling
- (2015) Ying Lu et al. CHEMICO-BIOLOGICAL INTERACTIONS
- PKC Attenuates Jagged-1-Mediated Notch Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance
- (2015) K. Pandya et al. CLINICAL CANCER RESEARCH
- The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients
- (2015) Miao He et al. CLINICAL SCIENCE
- Matrix metalloproteinases as drivers and therapeutic targets in breast cancer
- (2015) Evette S. Radisky Frontiers in Bioscience-Landmark
- CEREBEL (EGF111438): A Phase III, Randomized, Open-Label Study of Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer
- (2015) Xavier Pivot et al. JOURNAL OF CLINICAL ONCOLOGY
- Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner
- (2015) Shan Shao et al. Molecular Cancer
- Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells
- (2015) Armine Matevossian et al. Molecular Cancer
- HER2 induced EMT and tumorigenicity in breast epithelial progenitor cells is inhibited by coexpression of EGFR
- (2015) S Ingthorsson et al. ONCOGENE
- Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia
- (2015) D Kern et al. ONCOGENE
- TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
- (2015) M-F Pang et al. ONCOGENE
- Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway
- (2015) YING-ZI FU et al. ONCOLOGY REPORTS
- p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling
- (2015) Elisa Maria Memmi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LGR5 Promotes Breast Cancer Progression and Maintains Stem-Like Cells Through Activation of Wnt/β-Catenin Signaling
- (2015) Lu Yang et al. STEM CELLS
- PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth
- (2015) Narinder Sharma et al. Oncotarget
- Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer
- (2015) Azeem Saleem et al. EJNMMI Research
- Hedgehog Signaling in the Maintenance of Cancer Stem Cells
- (2015) Catherine Cochrane et al. Cancers
- TGFβSignaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
- (2015) Panagiotis Papageorgis Journal of Oncology
- Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells
- (2015) Seiji Mori et al. PLoS One
- The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-β-Induced Epithelial to Mesenchymal Transition
- (2015) Michaël Ruff et al. PLoS One
- Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts
- (2015) Sílvia Cufí et al. Oncotarget
- ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer
- (2015) Katharina Feldinger et al. Oncotarget
- Quantitative Measurements of Tumoral p95HER2 Protein Expression in Metastatic Breast Cancer Patients Treated with Trastuzumab: Independent Validation of the p95HER2 Clinical Cutoff
- (2014) R. Duchnowska et al. CLINICAL CANCER RESEARCH
- Loss of E-cadherin expression is not a prerequisite for c-erbB2-induced epithelial-mesenchymal transition
- (2014) GISELA M.A. NILSSON et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Inhibition of Cdk2 kinase activity selectively targets the CD44+/CD24−/Low stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells
- (2014) MATEUSZ OPYRCHAL et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Ras Promotes Transforming Growth Factor-β (TGF-β)-induced Epithelial-Mesenchymal Transition via a Leukotriene B4Receptor-2-linked Cascade in Mammary Epithelial Cells
- (2014) Hyunju Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells
- (2014) Di Zhao et al. JOURNAL OF CLINICAL INVESTIGATION
- Fc-Optimized NKG2D–Fc Constructs Induce NK Cell Antibody-Dependent Cellular Cytotoxicity against Breast Cancer Cells Independently of HER2/neu Expression Status
- (2014) Stefanie Raab et al. JOURNAL OF IMMUNOLOGY
- Sonic hedgehog–Gli1 signals promote epithelial–mesenchymal transition in ovarian cancer by mediating PI3K/AKT pathway
- (2014) Zhang Ke et al. MEDICAL ONCOLOGY
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- STAT3 Signaling Is Activated Preferentially in Tumor-Initiating Cells in Claudin-Low Models of Human Breast Cancer
- (2014) Wei Wei et al. STEM CELLS
- Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer
- (2014) Andrew T. Baker et al. Frontiers in Oncology
- HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage
- (2013) Ji-hyun Ju et al. BIOCHEMICAL JOURNAL
- HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer
- (2013) Allan Lipton et al. BREAST CANCER RESEARCH AND TREATMENT
- HER2 Drives Luminal Breast Cancer Stem Cells in the Absence of HER2 Amplification: Implications for Efficacy of Adjuvant Trastuzumab
- (2013) S. Ithimakin et al. CANCER RESEARCH
- Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation
- (2013) C. Y.-F. Lee et al. CANCER RESEARCH
- Lapatinib inhibits stem/progenitor proliferation in preclinical in vitro models of ductal carcinoma in situ (DCIS)
- (2013) Gillian Farnie et al. CELL CYCLE
- Expression of Matrix Metalloproteinases in Human Breast Cancer Tissues
- (2013) Chellakkan Selvanesan Benson et al. DISEASE MARKERS
- Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses
- (2013) Diana J. Azzam et al. EMBO Molecular Medicine
- STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits
- (2013) SEYUNG S. CHUNG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition
- (2013) J Park et al. ONCOGENE
- Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition
- (2013) L Guo et al. ONCOGENE
- Signaling cross-talk in the resistance to HER family receptor targeted therapy
- (2013) H Yamaguchi et al. ONCOGENE
- Induction of epithelial–mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent
- (2013) F M Davis et al. ONCOGENE
- Targeting CD44-STAT3 Signaling by Gemini Vitamin D Analog Leads to Inhibition of Invasion in Basal-Like Breast Cancer
- (2013) Jae Young So et al. PLoS One
- Wnt Pathway Activity in Breast Cancer Sub-Types and Stem-Like Cells
- (2013) Rebecca Lamb et al. PLoS One
- Spontaneous Epithelial-Mesenchymal Transition and Resistance to HER-2-Targeted Therapies in HER-2-Positive Luminal Breast Cancer
- (2013) David Lesniak et al. PLoS One
- Differential Activation of Wnt-β-Catenin Pathway in Triple Negative Breast Cancer Increases MMP7 in a PTEN Dependent Manner
- (2013) Nandini Dey et al. PLoS One
- Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24− Subpopulations of Breast Cancer Cells
- (2013) Li Lin et al. PLoS One
- TGF-β-Id1 Signaling Opposes Twist1 and Promotes Metastatic Colonization via a Mesenchymal-to-Epithelial Transition
- (2013) Marko Stankic et al. Cell Reports
- Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis
- (2013) Vicki Plaks et al. Cell Reports
- Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway
- (2012) B. Ramaswamy et al. CANCER RESEARCH
- Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin)
- (2012) Cristina Oliveras-Ferraros et al. CELL CYCLE
- Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland
- (2012) Renée van Amerongen et al. Cell Stem Cell
- TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
- (2012) S. Lamouille et al. JOURNAL OF CELL SCIENCE
- Expression of Wnt3 Activates Wnt/ -Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells
- (2012) Y. Wu et al. MOLECULAR CANCER RESEARCH
- Epithelial-Mesenchymal Transition and Stem Cell Markers in Patients with HER2-Positive Metastatic Breast Cancer
- (2012) A. Giordano et al. MOLECULAR CANCER THERAPEUTICS
- TGFβ signalling in context
- (2012) Joan Massagué NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Activation Status of Wnt/ß-Catenin Signaling in Normal and Neoplastic Breast Tissues: Relationship to HER2/neu Expression in Human and Mouse
- (2012) Sara Khalil et al. PLoS One
- Correlation of HER2, p95HER2 and HER3 Expression and Treatment Outcome of Lapatinib plus Capecitabine in her2-Positive Metastatic Breast Cancer
- (2012) Sae-Won Han et al. PLoS One
- Correction: Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model
- (2012) Bhuvanesh Dave et al. PLoS One
- Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2+:ER - breast cancer
- (2012) J. C. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence
- (2011) K Pandya et al. BRITISH JOURNAL OF CANCER
- TGF /TNF -Mediated Epithelial-Mesenchymal Transition Generates Breast Cancer Stem Cells with a Claudin-Low Phenotype
- (2011) M. K. Asiedu et al. CANCER RESEARCH
- Nuclear ErbB2 Enhances Translation and Cell Growth by Activating Transcription of Ribosomal RNA Genes
- (2011) L.-Y. Li et al. CANCER RESEARCH
- HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis
- (2011) Z. C. Hartman et al. CANCER RESEARCH
- p95HER2 and Breast Cancer
- (2011) J. Arribas et al. CANCER RESEARCH
- CD24 enhances DNA damage-induced apoptosis by modulating NF-κB signaling in CD44-expressing breast cancer cells
- (2011) Ji-hyun Ju et al. CARCINOGENESIS
- Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
- (2011) Christina Scheel et al. CELL
- From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer
- (2011) Benjamin Tiede et al. CELL RESEARCH
- CD24 promotes tumor cell invasion by suppressing tissue factor pathway inhibitor-2 (TFPI-2) in a c-Src-dependent fashion
- (2011) Niko Bretz et al. CLINICAL & EXPERIMENTAL METASTASIS
- Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells
- (2011) Héctor Hernández-Vargas et al. Epigenetics
- Hyaluronan Facilitates Transforming Growth Factor-β1-dependent Proliferation via CD44 and Epidermal Growth Factor Receptor Interaction
- (2011) Soma Meran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
- (2011) Lauren L.C. Marotta et al. JOURNAL OF CLINICAL INVESTIGATION
- When Tumor Suppressor TGFβ Meets the HER2 (ERBB2) Oncogene
- (2011) Amy Chow et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy
- (2011) Phuc V Pham et al. Journal of Translational Medicine
- Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial
- (2011) Luca Gianni et al. LANCET ONCOLOGY
- Notch1 Inhibition Alters the CD44hi/CD24lo Population and Reduces the Formation of Brain Metastases from Breast Cancer
- (2011) P. M. McGowan et al. MOLECULAR CANCER RESEARCH
- Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
- (2011) Siyuan Zhang et al. NATURE MEDICINE
- Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
- (2011) Thordur Oskarsson et al. NATURE MEDICINE
- The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation
- (2011) J T Buijs et al. ONCOGENE
- Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+breast cancer patients
- (2011) Maurizio Scaltriti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome
- (2010) Andrey I. Khramtsov et al. AMERICAN JOURNAL OF PATHOLOGY
- Dynamic emergence of the mesenchymal CD44posCD24neg/low phenotype in HER2-gene amplified breast cancer cells with de novo resistance to trastuzumab (Herceptin)
- (2010) Cristina Oliveras-Ferraros et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Multiple molecular mechanisms underlying trastuzumab and lapatinib resistance in JIMT-1 breast cancer cells
- (2010) Katri Köninki et al. CANCER LETTERS
- Inhibition of Notch signaling reduces the stem-like cell population in T47D breast cancer cells and prevents mammosphere formation.
- (2010) P Grudzien et al. CANCER RESEARCH
- Smad Signaling Is Required to Maintain Epigenetic Silencing during Breast Cancer Progression
- (2010) P. Papageorgis et al. CANCER RESEARCH
- Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor
- (2010) H. Harrison et al. CANCER RESEARCH
- Combined inhibitory effect of formestane and herceptin on a subpopulation of CD44+/CD24low breast cancer cells
- (2010) Carla Cavaliere et al. CANCER SCIENCE
- Quantitation of p95HER2 in Paraffin Sections by Using a p95-Specific Antibody and Correlation with Outcome in a Cohort of Trastuzumab-Treated Breast Cancer Patients
- (2010) J. Sperinde et al. CLINICAL CANCER RESEARCH
- Context-Dependent Bidirectional Regulation of the MutS Homolog 2 by Transforming Growth Factor Contributes to Chemoresistance in Breast Cancer Cells
- (2010) Y. Yu et al. MOLECULAR CANCER RESEARCH
- Markers of Tumor-Initiating Cells Predict Chemoresistance in Breast Cancer
- (2010) Chang Gong et al. PLoS One
- Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models
- (2010) H. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells
- (2010) Irene Ma et al. Stem Cell Reviews and Reports
- HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer
- (2010) Merel Gijsen et al. PLOS BIOLOGY
- Expression of matrix metalloproteinases (MMPs) in primary human breast cancer and breast cancer cell lines: New findings and review of the literature
- (2009) Andrea Köhrmann et al. BMC CANCER
- Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer
- (2009) Karin Rennstam et al. BREAST CANCER RESEARCH AND TREATMENT
- Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
- (2009) Teemu T. Junttila et al. CANCER CELL
- Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer
- (2009) Panayiotis A. Theodoropoulos et al. CANCER LETTERS
- Immunoselection of Breast and Ovarian Cancer Cells with Trastuzumab and Natural Killer Cells: Selective Escape of CD44high/CD24low/HER2low Breast Cancer Stem Cells
- (2009) F. Reim et al. CANCER RESEARCH
- Tumor-Initiating Cells of HER2-Positive Carcinoma Cell Lines Express the Highest Oncoprotein Levels and Are Sensitive to Trastuzumab
- (2009) A. Magnifico et al. CLINICAL CANCER RESEARCH
- Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
- (2009) M.-H. Chen et al. GENES & DEVELOPMENT
- The basics of epithelial-mesenchymal transition
- (2009) Raghu Kalluri et al. JOURNAL OF CLINICAL INVESTIGATION
- A Naturally Occurring HER2 Carboxy-Terminal Fragment Promotes Mammary Tumor Growth and Metastasis
- (2009) K. Pedersen et al. MOLECULAR AND CELLULAR BIOLOGY
- Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis
- (2009) Suruchi Mittal et al. Molecular Cancer
- ErbB2-Mediated Src and Signal Transducer and Activator of Transcription 3 Activation Leads to Transcriptional Up-Regulation of p21Cip1 and Chemoresistance in Breast Cancer Cells
- (2009) V. S. Hawthorne et al. MOLECULAR CANCER RESEARCH
- Stat3 is required for anchorage-independent growth and metastasis but not for mammary tumor development downstream of the ErbB-2 oncogene
- (2009) Isaia Barbieri et al. MOLECULAR CARCINOGENESIS
- Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells
- (2009) N J Sullivan et al. ONCOGENE
- Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
- (2009) C. J. Creighton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling
- (2009) H. O.-L. Cheung et al. Science Signaling
- Tissue-Specific Promoters Active in CD44+CD24-/low Breast Cancer Cells
- (2008) G. J. Bauerschmitz et al. CANCER RESEARCH
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Roles of TGF-β family signaling in stem cell renewal and differentiation
- (2008) Tetsuro Watabe et al. CELL RESEARCH
- Non-Smad pathways in TGF-β signaling
- (2008) Ying E Zhang CELL RESEARCH
- Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment
- (2008) Toula Bouras et al. Cell Stem Cell
- ERK5/MAPK is activated by TGFβ in hepatocytes and required for the GSK-3β-mediated Snail protein stabilization
- (2008) Alessandra Marchetti et al. CELLULAR SIGNALLING
- A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
- (2008) Ulrike Burk et al. EMBO REPORTS
- The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
- (2008) S.-M. Park et al. GENES & DEVELOPMENT
- The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2
- (2008) Manav Korpal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β
- (2008) Kana Horiguchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Slug is a direct Notch target required for initiation of cardiac cushion cellularization
- (2008) Kyle Niessen et al. JOURNAL OF CELL BIOLOGY
- High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability
- (2008) Alysha K. Croker et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Refinement of breast cancer classification by molecular characterization of histological special types
- (2008) B Weigelt et al. JOURNAL OF PATHOLOGY
- Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy
- (2008) X. Li et al. JNCI-Journal of the National Cancer Institute
- Chromatin Immunoprecipitation on Microarray Analysis of Smad2/3 Binding Sites Reveals Roles of ETS1 and TFAP2A in Transforming Growth Factor Signaling
- (2008) D. Koinuma et al. MOLECULAR AND CELLULAR BIOLOGY
- The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
- (2008) Philip A. Gregory et al. NATURE CELL BIOLOGY
- HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
- (2008) H Korkaya et al. ONCOGENE
- ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a γ-secretase inhibitor
- (2008) C Osipo et al. ONCOGENE
- Trastuzumab in the Adjuvant Treatment of Early-Stage Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- (2008) I. J. Dahabreh et al. ONCOLOGIST
- Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
- (2008) Anne-Pierre Morel et al. PLoS One
- Notch signaling mediates hypoxia-induced tumor cell migration and invasion
- (2008) C. Sahlgren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expression profiles of protein tyrosine kinase genes in human embryonic stem cells
- (2008) Mi-Young Son et al. REPRODUCTION
- Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle permutations
- (2007) David M. Burns et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation