Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?

Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis

(2017) Katrin Echtler et al.   PLoS One

Disulfide Bonds as Regulators of Integrin Function in Thrombosis and Hemostasis

(2016) Ronit Mor-Cohen   ANTIOXIDANTS & REDOX SIGNALING

Metastasis: new functional implications of platelets and megakaryocytes

(2016) Raphael Leblanc et al.   BLOOD

Aspirin/antiplatelet agent use improves disease-free survival and reduces the risk of distant metastases in Stage II and III triple-negative breast cancer patients

(2016) J. Shiao et al.   BREAST CANCER RESEARCH AND TREATMENT

The role of integrins in TGFβ activation in the tumour stroma

(2016) Zareen Khan et al.   CELL AND TISSUE RESEARCH

Involvement of platelets in tumor cell metastasis

(2016) Belay Tesfamariam   PHARMACOLOGY & THERAPEUTICS

Research advances on structure and biological functions of integrins

(2016) Li Pan et al.   SpringerPlus

Purinergic Receptors in Thrombosis and Inflammation

(2015) Béatrice Hechler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of integrins in platelets

(2015) Joel S. Bennett   BIOPOLYMERS

Platelets in cancer

(2015) E. Mammadova-Bach et al.   Hamostaseologie

Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in Hematogenous Metastasis

(2015) Wenhui Qian et al.   JOURNAL OF VASCULAR RESEARCH

Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity

(2015) Eric Maurer et al.   THROMBOSIS AND HAEMOSTASIS

Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis

(2015) Yao-Wen Chang et al.   Oncotarget

Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties

(2015) Alain C. Jung et al.   Oncotarget

RUC-4

(2014) Jihong Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Baicalein inhibits agonist- and tumor cell-induced platelet aggregation while suppressing pulmonary tumor metastasis via cAMP-mediated VASP phosphorylation along with impaired MAPKs and PI3K-Akt activation

(2014) Sung Dae Kim et al.   BIOCHEMICAL PHARMACOLOGY

The functional role of platelets in the regulation of angiogenesis

(2014) Tony G. Walsh et al.   PLATELETS

Emerging Evidence for Platelets as Immune and Inflammatory Effector Cells

(2014) Matthew T. Rondina et al.   Frontiers in Immunology

Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

(2013) Dagmar Schumacher et al.   CANCER CELL

Integrin α 6 β 1 Is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion, Activation, and Arterial Thrombosis

(2013) Mathieu Schaff et al.   CIRCULATION

MMP-2 Detective Silicon Nanowire Biosensor Using Enzymatic Cleavage Reaction

(2013) Jin-Ha Choi et al.   Journal of Biomedical Nanotechnology

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors

(2013) Florence Schaffner et al.   Cancers

A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment

(2012) W. Zhang et al.   BLOOD

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

Activated Platelets Interact with Lung Cancer Cells Through P-Selectin Glycoprotein Ligand-1

(2012) Liang Gong et al.   PATHOLOGY & ONCOLOGY RESEARCH

GPIIb/IIIa inhibitors: From bench to bedside and back to bench again

(2012) Paul C. Armstrong et al.   THROMBOSIS AND HAEMOSTASIS

Inhibition of MCF-7 breast cancer cell-induced platelet aggregation using a combination of antiplatelet drugs

(2012) LIAN LIAN et al.   Oncology Letters

The wolf in sheep’s clothing

(2012) Theresa Placke et al.   OncoImmunology

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

The Androgen Receptor Induces Integrin  6 1 to Promote Prostate Tumor Cell Survival via NF- B and Bcl-xL Independently of PI3K Signaling

(2011) L. E. Lamb et al.   CANCER RESEARCH

Targeting the Platelet Integrin GPIIb/IIIa

(2011) Christoph E. Hagemeyer et al.   CURRENT PHARMACEUTICAL DESIGN

A phase II, single-arm study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer

(2011) Katherine M. Bell-McGuinn et al.   GYNECOLOGIC ONCOLOGY

Distinct Roles for Rap1b Protein in Platelet Secretion and Integrin αIIbβ3Outside-in Signaling

(2011) Guoying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 Integrin Mediates Interaction of Melanoma Cells with Platelets

(2011) Anke S. Lonsdorf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The evolution of antiplatelet therapy in cardiovascular disease

(2011) Omair Yousuf et al.   Nature Reviews Cardiology

Platelets, inflammation and tissue regeneration

(2011) Alan Nurden   THROMBOSIS AND HAEMOSTASIS

Extracellular Matrix Proteins in Hemostasis and Thrombosis

(2011) W. Bergmeier et al.   Cold Spring Harbor Perspectives in Biology

Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

(2010) L. Erpenbeck et al.   BLOOD

Anti-platelet therapy: glycoprotein IIb-IIIa antagonists

(2010) David J. Schneider   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

The laminin binding integrin α6β1 in prostate cancer perineural invasion

(2010) Isis C. Sroka et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

(2010) Peter M Rothwell et al.   LANCET

Extracellular Engagement of  6 Integrin Inhibited Urokinase-Type Plasminogen Activator-Mediated Cleavage and Delayed Human Prostate Bone Metastasis

(2009) M. O. Ports et al.   CANCER RESEARCH

Platelet-Derived Transforming Growth Factor-  Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor Reactivity

(2009) H.-G. Kopp et al.   CANCER RESEARCH

Modified heparins inhibit integrin αIIbβ3mediated adhesion of melanoma cells to plateletsin vitroandin vivo

(2009) ChunMei Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

(2009) Hitoshi Takizawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrins in platelet activation

(2009) B. NIESWANDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet Adhesion under Flow

(2009) Zaverio M. Ruggeri   MICROCIRCULATION

Cell Adhesion Mechanisms in Platelets

(2008) David Varga-Szabo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Integrin alpha-2 and beta-3 gene polymorphisms and colorectal cancer risk

(2008) Armin Gerger et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE