Article
Engineering, Biomedical
Zhen Liu, Junfei Huang, Deni Kang, Yi Zhou, Lijuan Du, Qian Qu, Jin Wang, Lihong Wen, Danlan Fu, Zhiqi Hu, Yong Miao
Summary: An optimized 3-D co-culture system was developed to restore the hair-inductive characteristics of human dermal papilla cells (hDPCs) by mimicking the in-vivo microenvironment. The study showed that Matrigel-encapsulated hDPCs spontaneously formed hDPC aggregates (hDPAs) with better activity, higher proliferation rates, and less apoptosis and hypoxia. The co-culture with hair matrix cells and dermal sheath cup cells further enhanced the expression of hair regeneration-related genes and improved mature hair follicle induction.
ACTA BIOMATERIALIA
(2023)
Article
Cell Biology
Alireza Sohrabi, Austin E. Y. T. Lefebvre, Mollie J. Harrison, Michael C. Condro, Talia M. Sanazzaro, Gevick Safarians, Itay Solomon, Soniya Bastola, Shadi Kordbacheh, Nadia Toh, Harley I. Kornblum, Michelle A. Digman, Stephanie K. Seidlits
Summary: The mechanical properties of solid tumors play a crucial role in influencing tumor cell phenotype and invasive behavior. This study demonstrates that a soft, brain-like matrix can induce a metabolic shift in glioblastoma (GBM) cells towards glycolysis, leading to increased migration activities. These mechanical cues are transduced via CD44 and integrin receptors, resulting in metabolic and phenotypic changes in cancer cells.
Review
Biochemistry & Molecular Biology
Zongzhe Xuan, Vladimir Zachar, Cristian Pablo Pennisi
Summary: Urethral stricture is a common disorder in men that often requires reconstructive surgery. Current approaches use autologous tissue from the oral mucosa. However, recent research suggests that stem cells from adipose tissue and urine may also be potential candidates for future treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Yu Chen, Zhenghao Ye, Ursula Seidler, Dean Tian, Fang Xiao
Summary: During intestinal inflammation, niche cells around ISCs and their secreted niche factors can facilitate the regeneration of ISCs via niche signals. Additionally, the growth of ISCs can respond to inflammatory cells, inflammatory cytokines, and inflammatory signals. Understanding the adaptive mechanism of ISCs in supporting intestinal epithelial regeneration during inflammation is crucial for the treatment of patients with intestinal inflammation.
Review
Oncology
Yunong Xie, Stephanie Ma, Man Tong
Summary: Accumulating evidence suggests that cancer stem cells (CSCs) use reprogrammed metabolic strategies to adapt to a hostile tumor microenvironment (TME) for survival and maintenance of stemness. This metabolic alteration is facilitated by microenvironmental cues, including metabolites such as glucose, amino acids, and lipids, as well as environmental properties like hypoxia and acidity in the TME. Additionally, interactions between CSCs and tumor-infiltrating cells promote cancer stemness, contributing to tumor development and progression.
Article
Immunology
Magdalena Lang, Corinna Krump, Anastasia Meshcheryakova, Carmen Tam-Amersdorfer, Elke Schwarzenberger, Christina Passegger, Sally Connolly, Diana Mechtcheriakova, Herbert Strobl
Summary: Inflammatory and psoriatic epidermal signals instruct cDC2 cells to differentiate and acquire characteristics of multiple tissue-resident cell subsets. These cells express the efferocytosis receptor Axl and exhibit a bone morphogenetic protein (BMP) and p38MAPK signaling marker. In addition, inflammatory signals also induce the expression of the non-classical NFkB transcription factor RelB in a subset of cDC2 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Martina Addeo, Giuseppina Di Paola, Henu Kumar Verma, Simona Laurino, Sabino Russi, Pietro Zoppoli, Geppino Falco, Pellegrino Mazzone
Summary: Gastric cancer stem cells play a crucial role in the initiation and progression of gastric cancer, with features like self-renewal capability and resistance to current anticancer therapies. Targeting metabolic pathways of cancer stem cells could be a promising strategy in cancer therapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell & Tissue Engineering
Mauro Krampera, Katarina Le Blanc
Summary: MSCs have shown exceptional safety in clinical trials, but reliable potency assays to predict their immunosuppressive efficacy are still lacking. They are approved for certain diseases in Japan and Europe, but not in the United States. Researchers discuss potential mechanisms of action, experimental models, and approaches for identifying MSC effects in vivo.
Review
Biochemistry & Molecular Biology
Quentin Alle, Enora Le Borgne, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Aging is traditionally seen as an unavoidable process, but new strategies have been developed to delay or reverse aging. Some of these approaches may have medical applications to improve healthspan and longevity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Elisa Stellaria Grassi, Viola Ghiandai, Luca Persani
Summary: Recent studies have shown intratumoral heterogeneity in thyroid cancer, with cancer stem-like cells hypothesized to drive tumor heterogeneity, contributing to its metastatic potential and therapy resistance. These cancer stem cells primarily exist in specific tumor areas, known as stem cell niches.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Belgin Yalcin, Michelle Monje
Summary: Developmental myelination is a prolonged process with cell-intrinsic mechanisms and microenvironmental interactions guiding every aspect of myelination. Neuron-oligodendroglial interactions fine-tune neural circuit dynamics and promote healthy neurological function during development and throughout adult life.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Larischa de Wet, Anthony Williams, Marc Gillard, Steven Kregel, Sophia Lamperis, Lisa C. Gutgesell, Jordan E. Vellky, Ryan Brown, Kelly Conger, Gladell P. Paner, Heng Wang, Elizabeth E. Platz, Angelo M. De Marzo, Ping Mu, Jonathan L. Coloff, Russell Z. Szmulewitz, Donald J. Vander Griend
Summary: This study investigated the impact of SOX2 expression on patient outcomes and its function within prostate cancer cells. The results revealed that SOX2 expression promotes metastatic progression and therapy resistance in prostate cancer, and affects the metabolic pathways and metabolites of cancer cells. These findings contribute to a better understanding of the role of SOX2 in prostate cancer and suggest its potential as a biomarker and pharmacologic target in clinical settings.
Article
Materials Science, Multidisciplinary
Anish Hiresha Verma, Swarna Ganesh, Krishnan Venkatakrishnan, Bo Tan
Summary: This study used ultra-small gold nanoparticles as a nanoscale probe to demethylate the genomic DNA of cancer stem cells, leading to their reprogramming into cancer cells. The results showed a significant decrease in genetic and phenotypic stemness as well as cell cycle quiescence of lung cancer stem cells. This research opens up new avenues for effective anti-cancer treatments and precision nanomedicine.
APPLIED MATERIALS TODAY
(2023)
Article
Biochemistry & Molecular Biology
Yuting Liu, Jiangping He, Ruhai Chen, He Liu, Jocelyn Chen, Yujian Liu, Bo Wang, Lin Guo, Duanqing Pei, Jie Wang, Jing Liu, Jiekai Chen
Summary: The study found that the closing of somatic loci is slower in humans compared to mice, with the AP-1 motif highly enriched among closed loci. The introduction of JDP2 enhances human reprogramming, while known pluripotent factors like ESRRB, KDM2B, and SALL4 fail to increase human iPSC generation. JDP2 promotes the closing of somatic loci enriching AP-1 motifs to enhance human reprogramming.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sam Buckberry, Xiaodong Liu, Daniel Poppe, Jia Ping Tan, Guizhi Sun, Joseph Chen, Trung Viet Nguyen, Alex de Mendoza, Jahnvi Pflueger, Thomas Frazer, Dulce B. Vargas-Landin, Jacob M. Paynter, Nathan Smits, Ning Liu, John F. Ouyang, Fernando J. Rossello, Hun S. Chy, Owen J. L. Rackham, Andrew L. Laslett, James Breen, Geoffrey J. Faulkner, Christian M. Nefzger, Jose M. Polo, Ryan Lister
Summary: Cells undergo a significant epigenome reconfiguration during reprogramming to hiPS cells. The differences in epigenomes between hiPS cells and hES cells affect the function of hiPS cells. Researchers characterized the emergence and persistence of these epigenetic differences and developed a TNT reprogramming strategy that corrects epigenetic memory and aberrations, making hiPS cells more similar to hES cells at a molecular and functional level.
