Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function

Effects of Duchenne muscular dystrophy on muscle stiffness and response to electrically-induced muscle contraction: A 12-month follow-up

(2017) Lilian Lacourpaille et al.   NEUROMUSCULAR DISORDERS

New aspects of myofibrillar myopathies

(2016) Rudolf A. Kley et al.   CURRENT OPINION IN NEUROLOGY

Limb girdle muscular dystrophies

(2016) John Vissing   CURRENT OPINION IN NEUROLOGY

Work Done by Titin Protein Folding Assists Muscle Contraction

(2016) Jaime Andrés Rivas-Pardo et al.   Cell Reports

New insights into the protein aggregation pathology in myotilinopathy by combined proteomic and immunolocalization analyses

(2016) A. Maerkens et al.   Acta Neuropathologica Communications

Titin stiffness modifies the force-generating region of muscle sarcomeres

(2016) Yong Li et al.   Scientific Reports

Myofibrillar instability exacerbated by acute exercise in filaminopathy

(2015) Frédéric Chevessier et al.   HUMAN MOLECULAR GENETICS

S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding

(2014) Jorge Alegre-Cebollada et al.   CELL

Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke

(2014) Paul Nicholls et al.   FEBS LETTERS

Regulation of protein turnover by heat shock proteins

(2014) Perinur Bozaykut et al.   FREE RADICAL BIOLOGY AND MEDICINE

Small heat shock proteins translocate to the cytoskeleton in human skeletal muscle following eccentric exercise independently of phosphorylation

(2014) Noni T. Frankenberg et al.   JOURNAL OF APPLIED PHYSIOLOGY

Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins

(2014) Sebastian Kötter et al.   JOURNAL OF CELL BIOLOGY

Chemical chaperone ameliorates pathological protein aggregation in plectin-deficient muscle

(2014) Lilli Winter et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-invasive assessment of muscle stiffness in patients with duchenne muscular dystrophy

(2014) Lilian Lacourpaille et al.   MUSCLE & NERVE

The 2015 version of the gene table of monogenic neuromuscular disorders (nuclear genome)

(2014) Jean-Claude Kaplan et al.   NEUROMUSCULAR DISORDERS

Chaperoning heat shock proteins: Proteomic analysis and relevance for normal and dystrophin-deficient muscle

(2014) Heinrich Brinkmeier et al.   Proteomics Clinical Applications

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol

(2013) Saskia Lassche et al.   BMC Neurology

Crucial Role for Ca 2+ /Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation

(2013) Nazha Hamdani et al.   CIRCULATION RESEARCH

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

Differential proteomic analysis of abnormal intramyoplasmic aggregates in desminopathy

(2013) A. Maerkens et al.   Journal of Proteomics

Muscular dystrophies

(2013) Eugenio Mercuri et al.   LANCET

Filamin C-related myopathies: pathology and mechanisms

(2012) Dieter O. Fürst et al.   ACTA NEUROPATHOLOGICA

Influences of temperature, oxidative stress, and phosphorylation on binding of heat shock proteins in skeletal muscle fibers

(2012) Noni T. Larkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function

(2012) Tobias Voelkel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pathophysiology of protein aggregation and extended phenotyping in filaminopathy

(2012) Rudolf A. Kley et al.   BRAIN

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

(2012) L. T. Donlin et al.   GENES & DEVELOPMENT

A Combined Laser Microdissection and Mass Spectrometry Approach Reveals New Disease Relevant Proteins Accumulating in Aggregates of Filaminopathy Patients

(2012) Rudolf A. Kley et al.   MOLECULAR & CELLULAR PROTEOMICS

Thick-Filament Strain and Interfilament Spacing in Passive Muscle: Effect of Titin-Based Passive Tension

(2011) Thomas Irving et al.   BIOPHYSICAL JOURNAL

Large Potentials of Small Heat Shock Proteins

(2011) Evgeny V. Mymrikov et al.   PHYSIOLOGICAL REVIEWS

Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions

(2011) Eman Basha et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Giant Protein Titin as an Integrator of Myocyte Signaling Pathways

(2010) Wolfgang A. Linke et al.   PHYSIOLOGY

Loss of Smyhc1 or Hsp90α1 Function Results in Different Effects on Myofibril Organization in Skeletal Muscles of Zebrafish Embryos

(2010) Marta Codina et al.   PLoS One

Structure and Mechanism of Protein Stability Sensors: Chaperone Activity of Small Heat Shock Proteins

(2009) Hassane S. Mchaourab et al.   BIOCHEMISTRY

PKC Phosphorylation of Titin’s PEVK Element

(2009) Carlos Hidalgo et al.   CIRCULATION RESEARCH

Subcellular movement and expression of HSP27, αB-crystallin, and HSP70 after two bouts of eccentric exercise in humans

(2009) G. Paulsen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Protective Effect of Geranylgeranylacetone via Enhancement of HSPB8 Induction in Desmin-Related Cardiomyopathy

(2009) Atsushi Sanbe et al.   PLoS One

The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis

(2008) T. A. Hawkins et al.   DEVELOPMENT