Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity

Distinct Membrane Disruption Pathways Are Induced by 40-Residue β-Amyloid Peptides

(2016) Dennis A. Delgado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Phenotypic spectrum of alpha-synuclein mutations: New insights from patients and cellular models

(2016) Simona Petrucci et al.   PARKINSONISM & RELATED DISORDERS

Foldamer-mediated manipulation of a pre-amyloid toxin

(2016) Sunil Kumar et al.   Nature Communications

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

(2016) Rehana Akter et al.   Journal of Diabetes Research

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity

(2015) Daniel Ysselstein et al.   NEUROBIOLOGY OF DISEASE

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

In Vitro Study of α-Synuclein Protofibrils by Cryo-EM Suggests a Cu2+-Dependent Aggregation Pathway

(2013) Hangyu Zhang et al.   BIOPHYSICAL JOURNAL

α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity

(2013) Robert H. C. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains

(2012) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

Structural Intermediates during α-Synuclein Fibrillogenesis on Phospholipid Vesicles

(2012) Gemma Comellas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radiating Amyloid Fibril Formation on the Surface of Lipid Membranes through Unit-Assembly of Oligomeric Species of α-Synuclein

(2012) Jung-Ho Lee et al.   PLoS One

Mechanism of Membrane Interaction and Disruption by α-Synuclein

(2011) Nicholas P. Reynolds et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

First appraisal of brain pathology owing to A30P mutant alpha-synuclein

(2010) K Seidel et al.   ANNALS OF NEUROLOGY

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

(2010) Tim Bartels et al.   BIOPHYSICAL JOURNAL

Adsorption of α-Synuclein on Lipid Bilayers: Modulating the Structure and Stability of Protein Assemblies

(2010) Farzin Haque et al.   JOURNAL OF PHYSICAL CHEMISTRY B

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

α-Synuclein and dopamine at the crossroads of Parkinson's disease

(2010) Lara Lourenço Venda et al.   TRENDS IN NEUROSCIENCES

Lipid bilayer disruption by oligomeric α-synuclein depends on bilayer charge and accessibility of the hydrophobic core

(2009) Bart D. van Rooijen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Clustering of α -Synuclein on Supported Lipid Bilayers: Role of Anionic Lipid, Protein, and Divalent Ion Concentration

(2009) Anjan P. Pandey et al.   BIOPHYSICAL JOURNAL

A Peptidomimetic Approach to Targeting Pre-amyloidogenic States in Type II Diabetes

(2009) James A. Hebda et al.   CHEMISTRY & BIOLOGY

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   JOURNAL OF MOLECULAR BIOLOGY

Membrane-Induced Folding of the cAMP-Regulated Phosphoprotein Endosulfine-α†

(2008) John M. Boettcher et al.   BIOCHEMISTRY

Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson’s disease

(2008) Fang Liu et al.   JOURNAL OF NEUROCHEMISTRY

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin

(2008) Jefferson D. Knight et al.   PROTEIN SCIENCE