The Plasticity of Th17 Cells in the Pathogenesis of Rheumatoid Arthritis

Associations between circulating IL-17 levels and rheumatoid arthritis and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis

(2017) Young Ho Lee et al.   POSTGRADUATE MEDICAL JOURNAL

Switching biologics in the treatment of psoriatic arthritis

(2017) Joseph F. Merola et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Secukinumab in Active Rheumatoid Arthritis: A Phase III Randomized, Double-Blind, Active Comparator- and Placebo-Controlled Study

(2017) Francisco J. Blanco et al.   Arthritis & Rheumatology

Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity

(2017) Katrina J. Binger et al.   Frontiers in Immunology

Reverse plasticity: TGF-β and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut

(2016) Jens Geginat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antibody engineering & therapeutics, the annual meeting of the antibody society December 7–10, 2015, San Diego, CA, USA

(2016) Matthias Pauthner et al.   mAbs

Anti-IL-17 therapy in treatment of rheumatoid arthritis: a systematic literature review and meta-analysis of randomized controlled trials

(2016) Sumit Kunwar et al.   RHEUMATOLOGY INTERNATIONAL

Efficacy and safety of monoclonal antibodies targeting interleukin-17 pathway for inflammatory arthritis: a meta-analysis of randomized controlled clinical trials

(2016) Min Wei et al.   Drug Design Development and Therapy

Ratio of Circulating IFNγ+“Th17 Cells” in Memory Th Cells Is Inversely Correlated with the Titer of Anti-CCP Antibodies in Early-Onset Rheumatoid Arthritis Patients Based on Flow Cytometry Methods of the Human Immunology Project

(2016) Shigeru Kotake et al.   Biomed Research International

Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161+Th1 Cells) to CD161+Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients

(2016) Shigeru Kotake et al.   Biomed Research International

Th1-Induced CD106 Expression Mediates Leukocytes Adhesion on Synovial Fibroblasts from Juvenile Idiopathic Arthritis Patients

(2016) Laura Maggi et al.   PLoS One

A cell-based bioassay for circulating bioactive IL-17: application to destruction in rheumatoid arthritis

(2015) Ndiémé Ndongo-Thiam et al.   ANNALS OF THE RHEUMATIC DISEASES

TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression

(2015) Hou-Pu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Safety and Efficacy of Open-label Subcutaneous Ixekizumab Treatment for 48 Weeks in a Phase II Study in Biologic-naive and TNF-IR Patients with Rheumatoid Arthritis

(2015) Mark C. Genovese et al.   JOURNAL OF RHEUMATOLOGY

Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases

(2015) Michela Silacci et al.   mAbs

Association ofHLA-DRB1alleles with clinical responses to the anti-interleukin-17A monoclonal antibody secukinumab in active rheumatoid arthritis

(2015) Gerd R. Burmester et al.   RHEUMATOLOGY

A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity

(2015) Mariana Esther Martinez-Sanchez et al.   PLoS Computational Biology

Human T helper type 1 dichotomy: origin, phenotype and biological activities

(2014) Francesco Annunziato et al.   IMMUNOLOGY

Th17 and Non-Classic Th1 Cells in Chronic Inflammatory Disorders: Two Sides of the Same Coin

(2014) Lorenzo Cosmi et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

One-year Efficacy and Safety Results of Secukinumab in Patients With Rheumatoid Arthritis: Phase II, Dose-finding, Double-blind, Randomized, Placebo-controlled Study

(2014) M. C. Genovese et al.   JOURNAL OF RHEUMATOLOGY

Anti-TNF and anti-IL-17 antibodies—better together!

(2014) Jenny Buckland   Nature Reviews Rheumatology

Circulating Th17 and Th1 cells expressing CD161 are associated with disease activity in rheumatoid arthritis

(2014) J Miao et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

A Phase II Randomized Study of Subcutaneous Ixekizumab, an Anti-Interleukin-17 Monoclonal Antibody, in Rheumatoid Arthritis Patients Who Were Naive to Biologic Agents or Had an Inadequate Response to Tumor Necrosis Factor Inhibitors

(2014) Mark C. Genovese et al.   Arthritis & Rheumatology

Brief Report: Etanercept Inhibits the Tumor Necrosis Factor α-Driven Shift of Th17 Lymphocytes Toward a Nonclassic Th1 Phenotype in Juvenile Idiopathic Arthritis

(2014) Laura Maggi et al.   Arthritis & Rheumatology

Combined Inhibition of Tumor Necrosis Factor α and Interleukin-17 As a Therapeutic Opportunity in Rheumatoid Arthritis: Development and Characterization of a Novel Bispecific Antibody

(2014) Jens A. A. Fischer et al.   Arthritis & Rheumatology

Mechanisms underlying helper T-cell plasticity: Implications for immune-mediated disease

(2013) Kiyoshi Hirahara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dynamic visualization of RANKL and Th17-mediated osteoclast function

(2013) Junichi Kikuta et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Circulating CD4+CD161+ T Lymphocytes Are Increased in Seropositive Arthralgia Patients but Decreased in Patients with Newly Diagnosed Rheumatoid Arthritis

(2013) Paulina Chalan et al.   PLoS One

Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study

(2012) Mark C Genovese et al.   ANNALS OF THE RHEUMATIC DISEASES

Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis

(2012) Maxime Samson et al.   ARTHRITIS AND RHEUMATISM

Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells

(2012) Laura Maggi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD4+CD161+ T Lymphocytes Infiltrate Crohn’s Disease-Associated Perianal Fistulas and Are Reduced by Anti-TNF-a Local Therapy

(2012) Laura Maggi et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis

(2011) Lorenzo Cosmi et al.   ARTHRITIS AND RHEUMATISM

Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis

(2010) Heidi Kokkonen et al.   ARTHRITIS AND RHEUMATISM

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

(2010) Yuta Kochi et al.   NATURE GENETICS

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

(2010) K. Nistala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

IL-17 in protective immunity to intracellular pathogens

(2010) Shabaana A. Khader et al.   Virulence

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

(2009) Natalia Martin-Orozco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-α antibody: A novel mechanism of osteoclastogenesis by IL-17

(2009) Toru Yago et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

(2009) David Bending et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

(2009) Melanie A. Kleinschek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PILAR is a novel modulator of human T-cell expansion

(2008) E. Huarte et al.   BLOOD

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE