Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

(2016) Amanda W. Lund et al.   JOURNAL OF CLINICAL INVESTIGATION

Visualization of immediate immune responses to pioneer metastatic cells in the lung

(2016) Mark B. Headley et al.   NATURE

Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice

(2016) Rituparna Das et al.   NATURE MEDICINE

The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations

(2016) Katrina Meeth et al.   Pigment Cell & Melanoma Research

Phase I Study of Random Healthy Donor-Derived Allogeneic Natural Killer Cell Therapy in Patients with Malignant Lymphoma or Advanced Solid Tumors

(2016) Y. Yang et al.   Cancer Immunology Research

Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice

(2016) Susann Rahmig et al.   Stem Cell Reports

Patient-Derived Xenograft Models for Pancreatic Adenocarcinoma Demonstrate Retention of Tumor Morphology through Incorporation of Murine Stromal Elements

(2015) Daniel Delitto et al.   AMERICAN JOURNAL OF PATHOLOGY

Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity

(2015) Enping Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor editing and genetic variability in human autoreactive B cells

(2015) Julie Lang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice

(2015) Inessa Schwab et al.   Cell Reports

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

The tumoral and stromal immune microenvironment in malignant pleural mesothelioma: A comprehensive analysis reveals prognostic immune markers

(2015) Hideki Ujiie et al.   OncoImmunology

“In vitro” 3D models of tumor-immune system interaction

(2014) Christian Hirt et al.   ADVANCED DRUG DELIVERY REVIEWS

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

(2014) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Inhibition of KRAS-Driven Tumorigenicity by Interruption of an Autocrine Cytokine Circuit

(2014) Z. Zhu et al.   Cancer Discovery

One mouse, one patient paradigm: New avatars of personalized cancer therapy

(2013) Prerna Malaney et al.   CANCER LETTERS

VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis

(2013) A. K. Alitalo et al.   CANCER RESEARCH

IDO expressing fibroblasts promote the expansion of antigen specific regulatory T cells

(2013) Terry-Ann Curran et al.   IMMUNOBIOLOGY

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

(2013) E. A. Akbay et al.   Cancer Discovery

Targeting Tregs in Malignant Brain Cancer: Overcoming IDO

(2013) Derek A. Wainwright et al.   Frontiers in Immunology

Vaccines for Pancreatic Cancer

(2012) Kevin C. Soares et al.   CANCER JOURNAL

IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival

(2012) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients

(2012) Elsa Quintana et al.   Science Translational Medicine

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF- 

(2011) J. Lohr et al.   CLINICAL CANCER RESEARCH

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors

(2011) Derek A. Wainwright et al.   NEURO-ONCOLOGY

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

(2011) J.-P. Gillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

Structures of PD-1 with its ligands: Sideways and dancing cheek to cheek

(2008) G. J. Freeman   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

(2007) Ronald J Buckanovich et al.   NATURE MEDICINE