Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains

Drugging Membrane Protein Interactions

(2016) Hang Yin et al.   Annual Review of Biomedical Engineering

Notch1 endocytosis is induced by ligand and is required for signal transduction

(2016) G. Chapman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways

(2016) Tilman Borggrefe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Role of Brain Cholesterol and its Oxidized Products in Alzheimer's Disease

(2016) Anna Maria Giudetti et al.   Current Alzheimer Research

Notch, lipids, and endothelial cells

(2016) Anaïs Briot et al.   CURRENT OPINION IN LIPIDOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Characterization of Small Isotropic Bicelles with Various Compositions

(2016) K. S. Mineev et al.   LANGMUIR

The many roles of Notch signaling during vertebrate somitogenesis

(2016) Kanu Wahi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

(2016) Philip C. Weisshuhn et al.   STRUCTURE

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

(2016) David M Bolduc et al.   eLife

Structural basis for KCNE3 modulation of potassium recycling in epithelia

(2016) B. M. Kroncke et al.   Science Advances

Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer's Disease and Beyond

(2015) Bart De Strooper et al.   Annual Review of Pharmacology and Toxicology

Notch Transmembrane Domain: Secondary Structure and Topology

(2015) Catherine L. Deatherage et al.   BIOCHEMISTRY

Amyloid beta-protein and lipid rafts focused on biogenesis and catabolism

(2015) Wataru Araki   Frontiers in Bioscience-Landmark

Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators

(2015) Motoo Kitagawa   JOURNAL OF BIOCHEMISTRY

Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail

(2015) Łukasz Nierzwicki et al.   Journal of Physical Chemistry Letters

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region

(2015) Xiang Xu et al.   STRUCTURE

Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

(2015) Marie Decock et al.   FEBS Open Bio

Side-Chain to Main-Chain Hydrogen Bonding Controls the Intrinsic Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix

(2014) Christina Scharnagl et al.   BIOPHYSICAL JOURNAL

Compensatory Flux Changes within an Endocytic Trafficking Network Maintain Thermal Robustness of Notch Signaling

(2014) Hideyuki Shimizu et al.   CELL

Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase

(2014) Thomas Lemmin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structural Heterogeneity in Transmembrane Amyloid Precursor Protein Homodimer Is a Consequence of Environmental Selection

(2014) Laura Dominguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Impact of Bilayer Lipid Composition on the Structure and Topology of the Transmembrane Amyloid Precursor C99 Protein

(2014) Yuanli Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development and Mechanism of γ-Secretase Modulators for Alzheimer’s Disease

(2013) Christina J. Crump et al.   BIOCHEMISTRY

Competition Between Homodimerization and Cholesterol Binding to the C99 Domain of the Amyloid Precursor Protein

(2013) Yuanli Song et al.   BIOCHEMISTRY

Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks

(2013) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

(2013) Daniel R. Roe et al.   Journal of Chemical Theory and Computation

Polyproline-II Helix in Proteins: Structure and Function

(2013) Alexei A. Adzhubei et al.   JOURNAL OF MOLECULAR BIOLOGY

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase

(2012) Oliver Holmes et al.   BIOCHEMISTRY

The Magic of Bicelles Lights Up Membrane Protein Structure

(2012) Ulrich H. N. Dürr et al.   CHEMICAL REVIEWS

Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment

(2012) Kirill D. Nadezhdin et al.   FEBS LETTERS

Generation of Alzheimer Disease-associated Amyloid β42/43Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

(2012) Edith Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ-Secretase

(2012) Oxana Pester et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis

(2012) M. Maulik et al.   MOLECULAR NEUROBIOLOGY

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Notch receptor–ligand binding and activation: Insights from molecular studies

(2012) Chandramouli R. Chillakuri et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NSAID-Based γ-Secretase Modulators Do Not Bind to the Amyloid-β Polypeptide

(2011) Paul J. Barrett et al.   BIOCHEMISTRY

Not(ch) just development: Notch signalling in the adult brain

(2011) Jessica L. Ables et al.   NATURE REVIEWS NEUROSCIENCE

Expression, purification, and reconstitution of the transmembrane domain of the human amyloid precursor protein for NMR studies

(2011) Wen Chen et al.   PROTEIN EXPRESSION AND PURIFICATION

Bicelles: Lipid Nanostructured Platforms with Potential Dermal Applications

(2011) Lucyanna Barbosa-Barros et al.   Small

Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?

(2010) Andrew J. Beel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Nonspecificity of Binding of γ-Secretase Modulators to the Amyloid Precursor Protein

(2009) Andrew J. Beel et al.   BIOCHEMISTRY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

(2009) Ian J. Martins et al.   JOURNAL OF NEUROCHEMISTRY

A helix-to-coil transition at the  -cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

(2009) T. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in the application of solution NMR spectroscopy to multi-span integral membrane proteins

(2009) Hak Jun Kim et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Structure of KCNE1 and Implications for How It Modulates the KCNQ1 Potassium Channel†‡

(2008) Congbao Kang et al.   BIOCHEMISTRY

Computationally Designed Peptide Inhibitors of Protein−Protein Interactions in Membranes†

(2008) Gregory A. Caputo et al.   BIOCHEMISTRY

Amyloidogenic Processing but Not Amyloid Precursor Protein (APP) Intracellular C-terminal Domain Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

(2008) Pascal Kienlen-Campard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular logic of Notch signaling - a structural and biochemical perspective

(2008) W. R. Gordon et al.   JOURNAL OF CELL SCIENCE

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE

More complicated than it looks: assembly of Notch pathway transcription complexes

(2008) R A Kovall   ONCOGENE