Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells

An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells

(2017) Scott G. Canfield et al.   JOURNAL OF NEUROCHEMISTRY

Streptococcus suis small RNA rss04 contributes to the induction of meningitis by regulating capsule synthesis and by inducing biofilm formation in a mouse infection model

(2017) Genhui Xiao et al.   VETERINARY MICROBIOLOGY

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

(2017) Ryan G. Lim et al.   Cell Reports

Host–pathogen interactions in bacterial meningitis

(2016) Kelly S. Doran et al.   ACTA NEUROPATHOLOGICA

SILAC and LC-MS/MS identification of Streptococcus equi ssp. zooepidemicus proteins that contribute to mouse brain microvascular endothelial cell infection

(2016) Ma Zhe et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Immortalized endothelial cell lines for in vitro blood–brain barrier models: A systematic review

(2016) Nurul Adhwa Rahman et al.   BRAIN RESEARCH

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells

(2016) Matthew J. Stebbins et al.   METHODS

Identification of CiaR Regulated Genes That Promote Group B Streptococcal Virulence and Interaction with Brain Endothelial Cells

(2016) Rong Mu et al.   PLoS One

Bacterial induction of Snail1 contributes to blood-brain barrier disruption

(2015) Brandon J. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Streptococcus agalactiae infection in zebrafish larvae

(2015) Brandon J. Kim et al.   MICROBIAL PATHOGENESIS

Srr2, a multifaceted adhesin expressed by ST-17 hypervirulent Group BStreptococcusinvolved in binding to both fibrinogen and plasminogen

(2015) Anne Six et al.   MOLECULAR MICROBIOLOGY

Identification of a Group B Streptococcal Fibronectin Binding Protein, SfbA, That Contributes to Invasion of Brain Endothelium and Development of Meningitis

(2014) R. Mu et al.   INFECTION AND IMMUNITY

Matrix Metalloproteinase Inhibition Lowers Mortality and Brain Injury in Experimental Pneumococcal Meningitis

(2014) Fabian D. Liechti et al.   INFECTION AND IMMUNITY

The Role of Autophagy during Group BStreptococcusInfection of Blood-Brain Barrier Endothelium

(2014) Andrew S. Cutting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Group B Streptococcal Serine-Rich Repeat Proteins Promote Interaction With Fibrinogen and Vaginal Colonization

(2014) N.-Y. Wang et al.   JOURNAL OF INFECTIOUS DISEASES

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

(2014) Ethan S. Lippmann et al.   Scientific Reports

Characterization of Fibrinogen Binding by Glycoproteins Srr1 and Srr2 ofStreptococcus agalactiae

(2013) Ho Seong Seo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Adult zebrafish model of bacterial meningitis in Streptococcus agalactiae infection

(2012) Hayley Patterson et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Defense at the border: the blood–brain barrier versus bacterial foreigners

(2012) Nina M van Sorge et al.   Future Microbiology

The CovS/CovR Acid Response Regulator Is Required for Intracellular Survival of Group B Streptococcus in Macrophages

(2012) Nicola J. Cumley et al.   INFECTION AND IMMUNITY

IbeA and OmpA of Escherichia coli K1 Exploit Rac1 Activation for Invasion of Human Brain Microvascular Endothelial Cells

(2012) Ravi Maruvada et al.   INFECTION AND IMMUNITY

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Cell Invasion by Neisseria meningitidis Requires a Functional Interplay between the Focal Adhesion Kinase, Src and Cortactin

(2012) Heiko Slanina et al.   PLoS One

Serine-Rich Repeat Proteins and Pili Promote Streptococcus agalactiae Colonization of the Vaginal Tract

(2011) T. R. Sheen et al.   JOURNAL OF BACTERIOLOGY

Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models

(2011) Kathryn Hatherell et al.   JOURNAL OF NEUROSCIENCE METHODS

Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration

(2011) Anirban Banerjee et al.   Nature Communications

Activation of brain endothelium by pneumococcal neuraminidase NanA promotes bacterial internalization

(2010) Anirban Banerjee et al.   CELLULAR MICROBIOLOGY

The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates

(2010) Asmaa Tazi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid

(2010) Sabien van Neerven et al.   JOURNAL OF NEUROIMMUNOLOGY

Regulation of CovR expression in Group B Streptococcus impacts blood-brain barrier penetration

(2010) Annalisa Lembo et al.   MOLECULAR MICROBIOLOGY

Neisseria meningitidis Induces Brain Microvascular Endothelial Cell Detachment from the Matrix and Cleavage of Occludin: A Role for MMP-8

(2010) Alexandra Schubert-Unkmeir et al.   PLoS Pathogens

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

(2009) Carlos J. Orihuela et al.   JOURNAL OF CLINICAL INVESTIGATION

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

(2009) Satoshi Uchiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Group B Streptococcal Serine‐Rich Repeat 1 Glycoprotein Mediates Penetration of the Blood‐Brain Barrier

(2009) Nina M. van Sorge et al.   JOURNAL OF INFECTIOUS DISEASES

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Recent advances in understanding the molecular basis of group B Streptococcus virulence

(2008) Heather C. Maisey et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

The CiaR Response Regulator in Group B Streptococcus Promotes Intracellular Survival and Resistance to Innate Immune Defenses

(2008) D. Quach et al.   JOURNAL OF BACTERIOLOGY

Retinoic acid dampens LPS-induced NF-κB activity: results from human monoblasts and in vivo imaging of NF-κB reporter mice

(2008) Liv M. Austenaa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Differential effects of hydrocortisone and TNFα on tight junction proteins in anin vitromodel of the human blood-brain barrier

(2008) Carola Förster et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anthrax Toxins Inhibit Neutrophil Signaling Pathways in Brain Endothelium and Contribute to the Pathogenesis of Meningitis

(2008) Nina M. van Sorge et al.   PLoS One