Attenuation of RNA viruses by redirecting their evolution in sequence space

Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growthin Vivo

(2016) Seth McDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

(2016) Eleanor Gaunt et al.   eLife

A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 enhances cell-mediated immune response and longevity of the total IgG to influenza A virus M2e protein in mice

(2015) Mehran Dabaghian et al.   ANTIVIRAL RESEARCH

Deep sequencing analysis of viral infection and evolution allows rapid and detailed characterization of viral mutant spectrum

(2015) Ofer Isakov et al.   BIOINFORMATICS

Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype

(2015) Antonio V. Bordería et al.   PLoS Pathogens

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication

(2014) Nicky J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization

(2014) C. Le Nouen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refining the Balance of Attenuation and Immunogenicity of Respiratory Syncytial Virus by Targeted Codon Deoptimization of Virulence Genes

(2014) J. Meng et al.   mBio

Costs and Benefits of Mutational Robustness in RNA Viruses

(2014) Adi Stern et al.   Cell Reports

Mutational and fitness landscapes of an RNA virus revealed through population sequencing

(2013) Ashley Acevedo et al.   NATURE

Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells

(2013) Antoine Nougairede et al.   PLoS Pathogens

Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity

(2013) Karla Tapia et al.   PLoS Pathogens

Codon Usage Determines the Mutational Robustness, Evolutionary Capacity, and Virulence of an RNA Virus

(2012) Adam S. Lauring et al.   Cell Host & Microbe

Coxsackievirus B3 mutator strains are attenuated in vivo

(2012) N. F. Gnadig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA virus genetic robustness: possible causes and some consequences

(2012) Santiago F Elena   Current Opinion in Virology

Misfolded Truncated Protein   Induces Innate Immune Response via MAPK Pathway

(2011) A. Kovac et al.   JOURNAL OF IMMUNOLOGY

Mutational Robustness of an RNA Virus Influences Sensitivity to Lethal Mutagenesis

(2011) J. D. Graci et al.   JOURNAL OF VIROLOGY

The Fitness Effects of Synonymous Mutations in DNA and RNA Viruses

(2011) José M. Cuevas et al.   MOLECULAR BIOLOGY AND EVOLUTION

Lethal mutagenesis of viruses

(2011) Celia Perales et al.   Current Opinion in Virology

Live attenuated influenza virus vaccines by computer-aided rational design

(2010) Steffen Mueller et al.   NATURE BIOTECHNOLOGY

Mutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studies

(2010) R. Sanjuan   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

(2010) Laura I. Levi et al.   PLoS Pathogens

Fine-Tuning Translation Kinetics Selection as the Driving Force of Codon Usage Bias in the Hepatitis A Virus Capsid

(2010) Lluís Aragonès et al.   PLoS Pathogens

Genetic robustness at the codon level as a measure of selection

(2009) Marco Archetti   GENE

Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa

(2009) A. R. Hall et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials

(2009) Thierry Boge et al.   VACCINE

Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

(2008) J. R. Coleman et al.   SCIENCE