2-Formylarylsulfonate from Aryne: A Sequential Reaction Strategy for Direct Synthesis of ortho-Hydroxyl-Protected Aryl Aldehydes

A novel transition-metal free synthetic strategy has been developed for the direct synthesis of 2-formylarylsulphonate from aryne precursor. The reaction proceeds via CO and C-C bond cleavage as well as C-O,C-C and O-S bond formations in a single reaction vessel. The methodology provides good yield of 2-formylarylsulphonates and tolerates variety of functional groups. The strategy opens a new avenue for the direct synthesis of ortho-hydroxyl-protected aryl aldehydes in organic synthesis.