EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity

PGE2 induced in and released by dying cells functions as an inhibitory DAMP

(2016) Sho Hangai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFN -Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2-Mediated Inhibition of Antitumor CTL Responses

(2016) F. S. Basingab et al.   Cancer Immunology Research

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection

(2015) Jonathan H Chen et al.   NATURE MEDICINE

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

(2015) Tauno Metsalu et al.   NUCLEIC ACIDS RESEARCH

Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis

(2015) Jian Chang et al.   Oncotarget

Consideration of the cellular microenvironment: Physiologically relevant co-culture systems in drug discovery

(2014) Ellen L. Berg et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer upregulated gene 2, a novel oncogene, confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling

(2013) W Malilas et al.   CANCER GENE THERAPY

The Continuum of Cancer Immunosurveillance: Prognostic, Predictive, and Mechanistic Signatures

(2013) Jérôme Galon et al.   IMMUNITY

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: DNAX Accessory Molecule 1-Deficient CD8+ T Cells Display Immunological Synapse Defects That Impair Antitumor Immunity

(2013) K. M. Ramsbottom et al.   JOURNAL OF IMMUNOLOGY

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells

(2013) M. J. Selby et al.   Cancer Immunology Research

Key role of the positive feedback between PGE2and COX2 in the biology of myeloid-derived suppressor cells

(2012) Nataša Obermajer et al.   OncoImmunology

Ontak reduces the immunosuppressive tumor environment and enhances successful therapeutic vaccination in HER-2/neu-tolerant mice

(2011) Angelos D. Gritzapis et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Blockade of Cytotoxic T-lymphocyte Antigen-4 by Ipilimumab is Associated with a Profound Long-Lasting Depletion of Foxp3+ Regulatory T Cells: A Mechanistic Explanation for Ipilimumab-Induced Severe Enterocolitis?

(2011) S. Nancey et al.   INFLAMMATORY BOWEL DISEASES

Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients

(2011) Annika Ålgars et al.   INTERNATIONAL JOURNAL OF CANCER

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

NK Cell Adoptive Transfer Combined with Ontak-Mediated Regulatory T Cell Elimination Induces Effective Adaptive Antitumor Immune Responses

(2011) M. Salagianni et al.   JOURNAL OF IMMUNOLOGY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Dendritic cell-associated lectin 2 (DCAL2) defines a distinct CD8α− dendritic cell subset

(2011) Shinji Kasahara et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

(2009) Alberto Mantovani et al.   HUMAN IMMUNOLOGY

PD-1 Is a Regulator of NY-ESO-1-Specific CD8+ T Cell Expansion in Melanoma Patients

(2009) J. Fourcade et al.   JOURNAL OF IMMUNOLOGY

The role of COX-2 in intestinal inflammation and colorectal cancer

(2009) D Wang et al.   ONCOGENE

De novo maintenance therapy with denileukin diftitox (Ontak®) in a patient with peripheral T‐cell lymphoma is associated with prolonged remission

(2008) Bryan Y. Wong et al.   AMERICAN JOURNAL OF HEMATOLOGY

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

Prevention of Both Direct and Cross-Priming of Antitumor CD8+ T-Cell Responses following Overproduction of Prostaglandin E2 by Tumor Cells In vivo

(2008) M. Ahmadi et al.   CANCER RESEARCH

The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages

(2008) Paola Allavena et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY