Article
Multidisciplinary Sciences
Daniel Gonzalez-Bohorquez, Isabel M. Gallego Lopez, Baptiste N. Jaeger, Sibylle Pfammatter, Megan Bowers, Clay F. Semenkovich, Sebastian Jessberger
Summary: The fate and behavior of neural progenitor cells play crucial roles in mammalian brain development. This study reveals the importance of de novo lipogenesis, mediated by fatty acid synthase (FASN), in regulating progenitor cell polarity and proliferation during mouse and human brain development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Food Science & Technology
Simon Steenson, Fariba Shojaee-Moradie, Julie A. Lovegrove, A. Margot Umpleby, Kim G. Jackson, Barbara A. Fielding
Summary: Fructose exacerbates post-prandial hypertriacylglycerolaemia by contributing substantially to de novo TAG-glycerol synthesis in Caco-2 cells, although it is not a major source of DNL.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Endocrinology & Metabolism
Da Som Lee, Tae Hyeon An, Hyunmi Kim, Eunsun Jung, Gyeonghun Kim, Seung Yeon Oh, Jun Seok Kim, Hye Jin Chun, Jaeeun Jung, Eun-Woo Lee, Baek-Soo Han, Dai Hoon Han, Yong-Ho Lee, Tae-Su Han, Keun Hur, Chul-Ho Lee, Dae-Soo Kim, Won Kon Kim, Jun Won Park, Seung-Hoi Koo, Je Kyung Seong, Sang Chul Lee, Hail Kim, Kwang-Hee Bae, Kyoung-Jin Oh
Summary: This study found that the expression of TCF7L2 in the liver affects hepatic lipid metabolism, and loss of TCF7L2 in the liver leads to excessive glycogen metabolism, promoting fatty acid accumulation and development of non-alcoholic fatty liver disease (NAFLD). Thus, TCF7L2 could be a potential regulator of NAFLD associated with high-carbohydrate diets and diabetes.
Article
Multidisciplinary Sciences
Leslie A. Rowland, Adilson Guilherme, Felipe Henriques, Chloe DiMarzio, Sean Munroe, Nicole Wetoska, Mark Kelly, Keith Reddig, Gregory Hendricks, Meixia Pan, Xianlin Han, Olga R. Ilkayeva, Christopher B. Newgard, Michael P. Czech
Summary: Fatty acid synthesis from carbohydrates by adipocytes has little contribution to fat storage. This study reveals that de novo lipogenesis (DNL) is critical for autophagy, as it provides fatty acids necessary for autophagosome and lysosome maturation and fusion. Deficiency of Fasn impairs autophagy and decreases certain membrane phosphoinositides needed for fusion. The dependence of autophagy on DNL cannot be fully compensated by exogenous fatty acids.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Truong San Phan, Leonhard Schink, Jasmin Mann, Verena M. Merk, Pascale Zwicky, Sarah Mundt, Dagmar Simon, Dagmar Kulms, Susanne Abraham, Daniel F. Legler, Mario Noti, Thomas Brunner
Summary: The research reveals that glucocorticoids produced by keratinocytes in the skin play a crucial role in regulating the immune system and inflammatory skin conditions. Lack of GC in mouse skin leads to spontaneous skin inflammation, shedding light on the importance of understanding skin homeostasis and pathology.
Review
Endocrinology & Metabolism
Bettina Geidl-Flueck, Philipp A. Gerber
Summary: This article examines the impact of sugar/fructose intake on hepatic de novo lipogenesis (DNL) and suggests that fructose is a more potent inducer of hepatic lipogenesis than glucose. The disruption of fructose metabolism under pathological conditions may lead to increased expression of fructolytic and lipogenic enzymes, contributing to ectopic fat deposition and impairment of various metabolic processes.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Cell Biology
Xinxin Song, Jiao Liu, Feimei Kuang, Xin Chen, Herbert J. Zeh, Rui Kang, Guido Kroemer, Yangchun Xie, Daolin Tang
Summary: Glucose determines the sensitivity of human pancreatic ductal carcinoma cells to ferroptosis and PDK4 is identified as the top gene responsible for ferroptosis resistance. Inhibiting PDK4 enhances the anticancer activity of system xc(-) inhibitors in vitro and in suitable preclinical mouse models. These findings suggest metabolic reprogramming as a potential target for overcoming ferroptosis resistance.
Article
Nutrition & Dietetics
Yuko Ishii, Orie Muta, Tomohiro Teshima, Nayuta Hirasima, Minayu Odaka, Taiki Fushimi, Yasuyuki Fujii, Naomi Osakabe
Summary: The study demonstrated that flavan 3-ol (FLs) may induce browning of adipose tissue in mice by activating the sympathetic nervous system (SNS), leading to increased expression of uncoupling protein (Ucp)-1 and thermogenic transcriptome factors. This effect was confirmed by a marked increase in urinary catecholamine (CA) levels, suggesting enhanced SNS activity.
Article
Endocrinology & Metabolism
Han Zeng, Hong Qin, Meng Liao, Enze Zheng, Xiaoqing Luo, Anhua Xiao, Yiyu Li, Lin Chen, Li Wei, Lei Zhao, Xiong Z. Ruan, Ping Yang, Yaxi Chen
Summary: This study found that CD36 plays a role in the development of NAFLD by facilitating the uptake of free fatty acids and enhancing de novo lipogenesis in hepatocytes. CD36 forms a complex with INSIG2, disrupting the interaction between SCAP and INSIG2, leading to the translocation of SREBP1 for processing. These findings provide new evidence for targeting CD36 as a potential therapeutic approach for NAFLD.
MOLECULAR METABOLISM
(2022)
Article
Nutrition & Dietetics
Woo Yong Park, Gahee Song, Joon Hak Noh, Taegon Kim, Jae Jin Kim, Seokbeom Hong, Jinbong Park, Jae-Young Um
Summary: The study investigated the pharmacological effect of RSWE on alcoholic fatty liver disease (AFLD) and found that RSWE has the potential to improve AFLD by inhibiting de novo lipogenesis in the liver. Supplementation with RSWE decreased liver fat accumulation and improved tissue structure in both mouse and cell models.
Article
Environmental Sciences
Xiaoyun Wang, Zhendong Sun, Yurou Gao, Qian S. Liu, Xiaoxi Yang, Jiefeng Liang, Jing Ren, Zhihua Ren, Qunfang Zhou, Guibin Jiang
Summary: The widespread usage of 3-tert-butyl-4-hydroxyanisole (3-BHA) as an anthropogenic antioxidant has caused considerable environmental contamination and frequent detection in diverse human-derived samples. Its effects on renal lipid metabolism remain uncertain, and this study investigates the impact of 3-BHA on lipid accumulation and the underlying mechanisms in human kidney cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Hector Hernando Salgado, Candido Pomar, Marie-France Palin, Helene Lapierre, Marie-Pierre Letourneau-Montminy, John P. Cant, Aline Remus
Summary: Variations in body composition among pigs are associated with insulin sensitivity, and fat pigs have higher lipogenesis and expression levels of lipogenic enzymes. Reduced insulin sensitivity in fat pigs is associated with higher expression levels of glucose-6-phosphate dehydrogenase and lower expression levels of peroxisome proliferator-activated receptor-gamma.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Xiangyun Tan, Yi Sun, Liang Chen, Junjie Hu, Yan Meng, Ming Yuan, Qi Wang, Shan Li, Guohua Zheng, Zhenpeng Qiu
Summary: This study aimed to evaluate the therapeutic efficacy of caffeine in a NASH mouse model. The results showed that caffeine improved hepatic steatosis and inflammatory injury by inhibiting two signaling pathways and reducing the production of proinflammatory mediators. These findings suggest that caffeine may be beneficial in the prevention and therapy of NASH.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Bing Zhou, Yunchen Luo, Nana Ji, Cheng Hu, Yan Lu
Summary: Alterations in hepatic lipid metabolism may contribute to the onset of non-alcoholic fatty liver disease. Zhou et al. identify orosomucoid 2 (ORM2) as a key regulator of lipid homeostasis in the liver. ORM2 activates the AMP-activated protein kinase signaling to inhibit lipogenesis. Additionally, injections of ORM2 protein improved liver steatosis and atherosclerosis.
Article
Multidisciplinary Sciences
Matthieu Lacroix, Laetitia K. Linares, Natalia Rueda-Rincon, Katarzyna Bloch, Michela Di Michele, Carlo De Blasio, Caroline Fau, Laurie Gayte, Emilie Blanchet, Aline Mairal, Rita Derua, Fernando Cardona, Diane Beuzelin, Jean-Sebastien Annicotte, Nelly Pirot, Adeline Torro, Francisco J. Tinahones, Florence Bernex, Justine Bertrand-Michel, Dominique Langin, Lluis Fajas, Johannes V. Swinnen, Laurent Le Cam
Summary: The deletion of the multifunctional protein E4F1 is protective against diet-induced obesity in mice, and E4F1 regulates adipocyte lipid metabolism through p53. The interaction between E4F1 and p53 plays a crucial role in controlling lipid metabolism in adipocytes, and this crosstalk is relevant to obesity and insulin resistance.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Anyuan He, Xiaowen Chen, Min Tan, Yali Chen, Dongliang Lu, Xiangyu Zhang, John M. Dean, Babak Razani, Irfan J. Lodhi
Article
Multidisciplinary Sciences
Thiago M. Batista, Sezin Dagdeviren, Shannon H. Carroll, Weikang Cai, Veronika Y. Melnik, Hye Lim Noh, Suchaorn Saengnipanthkul, Jason K. Kim, C. Ronald Kahn, Richard T. Lee
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Ryan G. Walker, Ornella Barrandon, Tommaso Poggioli, Sezin Dagdeviren, Shannon H. Carroll, Melanie J. Mills, Kourtney R. Mendello, Yanet Gomez, Francesco S. Loffredo, James R. Pancoast, Claudio Macias-Trevino, Colin Marts, Katherine B. LeClair, Hye-Lim Noh, Taekyoon Kim, Alexander S. Banks, Jason K. Kim, David E. Cohen, Amy J. Wagers, Douglas A. Melton, Richard T. Lee
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Adilson Guilherme, Batuhan Yenilmez, Alexander H. Bedard, Felipe Henriques, Dianxin Liu, Alexandra Lee, Lauren Goldstein, Mark Kelly, Sarah M. Nicoloro, Min Chen, Lee Weinstein, Sheila Collins, Michael P. Czech
Editorial Material
Cell Biology
Anyuan He, John M. Dean, Dongliang Lu, Yali Chen, Irfan J. Lodhi
Article
Physiology
Caroline de Carvalho Picoli, Gustavo Renan Gilio, Felipe Henriques, Luana Garcia Leal, Jean Carlos Besson, Magno Alves Lopes, Solange Marta Franzoi de Moraes, Luzmarina Hernandes, Miguel Luiz Batista Junior, Sidney Barnabe Peres
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Nutrition & Dietetics
Ling-Yu Li, Jia-Min Li, Li-Jun Ning, Dong-Liang Lu, Yuan Luo, Qiang Ma, Samwel Mchele Limbu, Dong-Liang Li, Li-Qiao Chen, Irfan J. Lodhi, Pascal Degrace, Mei-Ling Zhang, Zhen-Yu Du
JOURNAL OF NUTRITION
(2020)
Article
Cell Biology
Felipe Henriques, Alexander H. Bedard, Adilson Guilherme, Mark Kelly, Jingyi Chi, Peng Zhang, Lawrence M. Lifshitz, Karl Bellve, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, Lee S. Weinstein, Jiandie D. Lin, Paul Cohen, Michael P. Czech
Article
Cell Biology
Se-Jin Jeong, Jeremiah Stitham, Trent D. Evans, Xiangyu Zhang, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Joan Tao, Koki Takabatake, Slava Epelman, Irfan J. Lodhi, Joel D. Schilling, Brian J. Debosch, Abhinav Diwan, Babak Razani
Summary: The autophagy-lysosome system is crucial for recycling dysfunctional components in cells, and trehalose, a natural disaccharide, has the ability to induce autophagy by potentially affecting lysosomal function. This suggests that trehalose could serve as a therapeutic target for diseases associated with dysfunctional autophagy.
Article
Biochemistry & Molecular Biology
Larry D. Spears, Sangeeta Adak, Guifang Dong, Xiaochao Wei, George Spyropoulos, Qiang Zhang, Li Yin, Chu Feng, Donghua Hu, Irfan J. Lodhi, Fong-Fu Hsu, Rithwick Rajagopal, Kevin K. Noguchi, Carmen M. Halabi, Lindsey Brier, Annie R. Bice, Brian Lananna, Erik S. Musiek, Oshri Avraham, Valeria Cavalli, Jerrah K. Holth, David M. Holtzman, David F. Wozniak, Joseph P. Culver, Clay F. Semenkovich
Summary: Endothelium-derived ether lipids affect blood pressure, behavior, and neurodegeneration in mice.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Batuhan Yenilmez, Nicole Wetoska, Mark Kelly, Dimas Echeverria, Kyounghee Min, Lawrence Lifshitz, Julia F. Alterman, Matthew R. Hassler, Samuel Hildebrand, Chloe DiMarzio, Nicholas McHugh, Lorenc Vangjeli, Jacquelyn Sousa, Meixia Pan, Xianlin Han, Michael A. Brehm, Anastasia Khvorova, Michael P. Czech
Summary: Nonalcoholic steatohepatitis (NASH) is a severe liver disorder with no approved therapeutics available. In this study, RNAi-based therapy targeting the enzyme DGAT2 showed potential in improving the fatty liver phenotype, but had limited impact on inflammation and fibrosis.
Article
Multidisciplinary Sciences
Qingbo Chen, Lei Huang, Dongning Pan, Kai Hu, Rui Li, Randall H. Friedline, Jason K. Kim, Lihua Julie Zhu, David A. Guertin, Yong-Xu Wang
Summary: This study identifies a previously unknown adipokine called Adissp, which plays a key role in regulating white adipose tissue thermogenesis and glucose homeostasis. The results suggest that Adissp promotes white adipose tissue thermogenesis, improves glucose homeostasis, and protects against obesity. Adipose-specific knockout of Adissp leads to defective white adipose tissue browning and susceptibility to high fat diet-induced obesity and hyperglycemia.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Lianggong Ding, Wenfei Sun, Miroslav Balaz, Anyuan He, Manuel Klug, Stefan Wieland, Robert Caiazzo, Violeta Raverdy, Francois Pattou, Philippe Lefebvre, Irfan J. Lodhi, Bart Staels, Markus Heim, Christian Wolfrum
Summary: The study elucidates a cellular mechanism for sensing cellular fatty acid levels and adjusting lipolysis as needed, involving peroxisomal degradation of fatty acids, production of reactive oxygen species, and post-translational regulation of adipose triglyceride lipase.
Article
Medicine, Research & Experimental
Erica P. Homan, Bruna B. Brandao, Samir Softic, Abdelfattah El Ouaamari, Brian T. O'Neill, Rohit N. Kulkarni, Jason K. Kim, Ronald Kahn
Summary: The research found that FOXO transcription factors play different roles in the action of insulin/IGF-1 in different adipose tissue, with the most significant effect in BAT. While the loss of FOXOs in fat can partially rescue subcutaneous WAT and hepatosteatosis, it cannot rescue systemic insulin resistance and may lead to more severe hyperinsulinemia.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)