Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism

Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements

(2016) Michael J. Coyne et al.   BMC GENOMICS

Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations

(2016) Christoph A. Thaiss et al.   CELL

Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet–Induced Insulin Resistance

(2016) Wei Zhang et al.   DIABETES

Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

(2016) Marleen Schonewille et al.   JOURNAL OF LIPID RESEARCH

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Effect of Statins on Fasting Plasma Glucose in Diabetic and Nondiabetic Patients

(2016) Rishi Sukhija et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

(2016) Marialena Mouzaki et al.   PLoS One

Tax4Fun: predicting functional profiles from metagenomic 16S rRNA data: Fig. 1.

(2015) Kathrin P. Aßhauer et al.   BIOINFORMATICS

Proton pump inhibitors affect the gut microbiome

(2015) Floris Imhann et al.   GUT

Statins and New-Onset Diabetes Mellitus and Diabetic Complications: A Retrospective Cohort Study of US Healthy Adults

(2015) Ishak Mansi et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Ezetimibe and simvastatin modulate gut microbiota and expression of genes related to cholesterol metabolism

(2015) Emilie Catry et al.   LIFE SCIENCES

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

UProC: tools for ultra-fast protein domain classification

(2014) Peter Meinicke   BIOINFORMATICS

Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis

(2014) Ana Filipa Macedo et al.   BMC Medicine

Aspirated bile: a major host trigger modulating respiratory pathogen colonisation in cystic fibrosis patients

(2014) F. J. Reen et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice

(2014) Zidong Donna Fu et al.   JOURNAL OF LIPID RESEARCH

Statin treatment and new-onset diabetes: A review of proposed mechanisms

(2014) Marilyne Brault et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

An antimicrobial protein of the gut symbiontBacteroides fragiliswith a MACPF domain of host immune proteins

(2014) Maria Chatzidaki-Livanis et al.   MOLECULAR MICROBIOLOGY

Omeprazole and Lansoprazole Enantiomers Induce CYP3A4 in Human Hepatocytes and Cell Lines via Glucocorticoid Receptor and Pregnane X Receptor Axis

(2014) Aneta Novotna et al.   PLoS One

Narrative Review: Statin-Related Myopathy

(2013) Tisha R. Joy   ANNALS OF INTERNAL MEDICINE

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Vitamin D Receptor Activation Down-regulates the Small Heterodimer Partner and Increases CYP7A1 to Lower Cholesterol

(2013) Edwin C.Y. Chow et al.   GASTROENTEROLOGY

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Statins, inflammation and deep vein thrombosis: a systematic review

(2012) April L. Rodriguez et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

(2012) Christian Quast et al.   NUCLEIC ACIDS RESEARCH

Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota

(2011) Matteo Serino et al.   GUT

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

(2011) Wu Yin et al.   JOURNAL OF LIPID RESEARCH

The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes

(2011) Katharine Howe et al.   XENOBIOTICA

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans

(2010) H. Oberkofler et al.   DIABETOLOGIA

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

(2010) Maryam Rakhshandehroo et al.   PPAR Research

Statin Adverse Effects

(2009) Beatrice A Golomb et al.   American Journal of Cardiovascular Drugs

The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

(2009) Jie Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice

(2009) Changcheng Zhou et al.   JOURNAL OF LIPID RESEARCH

Evaluating the glucose tolerance test in mice

(2008) Sofianos Andrikopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response

(2008) Nico Scheer et al.   JOURNAL OF CLINICAL INVESTIGATION