Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism

(2013) X. Hu et al.   JOURNAL OF INTERNAL MEDICINE

Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression

(2013) Rex A. Parker et al.   JOURNAL OF LIPID RESEARCH

Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice

(2013) Zidong Donna Fu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Diet-Induced Alterations of Host Cholesterol Metabolism Are Likely To Affect the Gut Microbiota Composition in Hamsters

(2012) Inés Martínez et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Gender-Divergent Profile of Bile Acid Homeostasis during Aging of Mice

(2012) Zidong Donna Fu et al.   PLoS One

Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with Dyslipidemia

(2011) Rebecca A. Haeusler et al.   Cell Metabolism

Interaction of fluvastatin with the liver-specific Na+-dependent taurocholate cotransporting polypeptide (NTCP)

(2011) Rick Greupink et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism

(2011) Xiaosong Chen et al.   Experimental Diabetes Research

Pravastatin modulates liver bile acid and cholesterol homeostasis in rats with chronic cholestasis

(2011) Gabriela Kolouchova et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Simvastatin reduces atherogenesis and promotes the expression of hepatic genes associated with reverse cholesterol transport in apoE-knockout mice fed high-fat diet

(2011) Guohua Song et al.   Lipids in Health and Disease

Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice

(2010) Iván L. Csanaky et al.   HEPATOLOGY

Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice

(2010) Youcai Zhang et al.   JOURNAL OF LIPID RESEARCH

The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells

(2009) Alice Cristina Rodrigues et al.   ACTA PHARMACOLOGICA SINICA

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

(2009) Ichiro Ieiri et al.   Expert Opinion on Drug Metabolism & Toxicology

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes

(2009) Katalin Jemnitz et al.   TOXICOLOGY IN VITRO

Effects of Statins on High-Density Lipoproteins: A Potential Contribution to Cardiovascular Benefit

(2008) Fergus McTaggart et al.   CARDIOVASCULAR DRUGS AND THERAPY

Atorvastatin has hypolipidemic and anti-inflammatory effects in apoE/LDL receptor-double-knockout mice

(2008) Petr Nachtigal et al.   LIFE SCIENCES

Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin

(2008) H. Zaher et al.   MOLECULAR PHARMACOLOGY