Drug targets in dormant Mycobacterium tuberculosis: can the conquest against tuberculosis become a reality?

Rifampicin resistance after treatment for latent tuberculous infection: a systematic review and meta-analysis

(2016) S. den Boon et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

The perilipin-like PPE15 protein inMycobacterium tuberculosisis required for triacylglycerol accumulation under dormancy-inducing conditions

(2016) Jaiyanth Daniel et al.   MOLECULAR MICROBIOLOGY

Updates on the risk factors for latent tuberculosis reactivation and their managements

(2016) Jing-Wen Ai et al.   Emerging Microbes & Infections

Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them

(2015) Dimitrios Evangelopoulos et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Advances in Mycobacterial Isocitrate Lyase Targeting and Inhibitors

(2015) M. Kratky et al.   CURRENT MEDICINAL CHEMISTRY

Novel Regimens Identified in Mice for Treatment of Latent Tuberculosis Infection in Contacts of Patients with Multidrug-Resistant Tuberculosis

(2014) Jean-Philippe Lanoix et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of plant-derived natural products as potential inhibitors of the Mycobacterium tuberculosis proteasome

(2014) Yuejuan Zheng et al.   BMC Complementary and Alternative Medicine

DevR (DosR) mimetic peptides impair transcriptional regulation and survival of Mycobacterium tuberculosis under hypoxia by inhibiting the autokinase activity of DevS sensor kinase

(2014) Kohinoor Kaur et al.   BMC MICROBIOLOGY

PA-824 is as effective as isoniazid against latent tuberculosis infection in C3HeB/FeJ mice

(2014) Noton K. Dutta et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Protein Kinase B (PknB) ofMycobacterium tuberculosisIs Essential for Growth of the Pathogenin Vitroas well as for Survival within the Host

(2014) Yogesh Chawla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Latent Tuberculosis Infection: Myths, Models, and Molecular Mechanisms

(2014) N. K. Dutta et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Whole Genome Sequencing of Mycobacterium tuberculosis Reveals Slow Growth and Low Mutation Rates during Latent Infections in Humans

(2014) Roberto Colangeli et al.   PLoS One

An Acyl-CoA Synthetase in Mycobacterium tuberculosis Involved in Triacylglycerol Accumulation during Dormancy

(2014) Jaiyanth Daniel et al.   PLoS One

Increased virulence of Mycobacterium tuberculosis H37Rv overexpressing LipY in a murine model

(2014) Vipul K. Singh et al.   TUBERCULOSIS

Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria

(2014) I. A. Rodionova et al.   mBio

Mycobacterium tuberculosis Ser/Thr Protein Kinase B Mediates an Oxygen-Dependent Replication Switch

(2014) Corrie Ortega et al.   PLOS BIOLOGY

Reduced Drug Uptake in Phenotypically Resistant Nutrient-Starved Nonreplicating Mycobacterium tuberculosis

(2013) Jansy Sarathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia

(2013) Anil K. Saxena et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Essentiality of DevR/DosR Interaction with SigA for the Dormancy Survival Program in Mycobacterium tuberculosis

(2013) U. S. Gautam et al.   JOURNAL OF BACTERIOLOGY

Nitrite Reductase NirBD Is Induced and Plays an Important Role during In Vitro Dormancy of Mycobacterium tuberculosis

(2013) S. Akhtar et al.   JOURNAL OF BACTERIOLOGY

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

(2013) J.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The LuxR family regulator Rv0195 modulates Mycobacterium tuberculosis dormancy and virulence

(2013) Haihong Fang et al.   TUBERCULOSIS

Synthesis and characterization of pyruvate–isoniazid analogs and their copper complexes as potential ICL inhibitors

(2012) Dipti Shingnapurkar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

(2012) Timothy M. Chapman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of Mannich Base as a Novel Inhibitor of Mycobacterium Tuberculosis Isocitrate by High-Throughput Screening

(2012) Lei Ji et al.   International Journal of Biological Sciences

Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis

(2012) Joy Debnath et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potential of Mycobacterium tuberculosis resuscitation-promoting factors as antigens in novel tuberculosis sub-unit vaccines

(2011) M. Romano et al.   MICROBES AND INFECTION

Nitrate reduction pathways in mycobacteria and their implications during latency

(2011) A. Khan et al.   MICROBIOLOGY-SGM

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection

(2011) Christopher B Ford et al.   NATURE GENETICS

Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection

(2011) Timothy R. Sterling et al.   NEW ENGLAND JOURNAL OF MEDICINE

Production and Characterization of Monoclonal Antibody Against Mycobacterium tuberculosis RpfB Domain

(2010) Ailin Fan et al.   HYBRIDOMA

Different Roles of DosS and DosT in the Hypoxic Adaptation of Mycobacteria

(2010) M.-J. Kim et al.   JOURNAL OF BACTERIOLOGY

DosS Responds to a Reduced Electron Transport System To Induce the Mycobacterium tuberculosis DosR Regulon

(2010) R. W. Honaker et al.   JOURNAL OF BACTERIOLOGY

5-Nitro-2,6-dioxohexahydro-4-pyrimidinecarboxamides: synthesis,in vitroantimycobacterial activity, cytotoxicity, and isocitrate lyase inhibition studies

(2010) Dharmarajan Sriram et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling

(2009) Bavesh Davandra Kana et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Unique Roles of DosT and DosS in DosR Regulon Induction and Mycobacterium tuberculosis Dormancy

(2009) R. W. Honaker et al.   INFECTION AND IMMUNITY

Structural Insight into the Heme-based Redox Sensing by DosS fromMycobacterium tuberculosis

(2009) Ha Yeon Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Design of DevR Inhibitor Active against NonreplicatingMycobacterium tuberculosis

(2009) Rajesh Kumar Gupta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence

(2009) Rakesh K. Dhiman et al.   MOLECULAR MICROBIOLOGY

Inhibitors selective for mycobacterial versus human proteasomes

(2009) Gang Lin et al.   NATURE

A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen

(2009) Chirajyoti Deb et al.   PLoS One

Finding of the Low Molecular Weight Inhibitors of Resuscitation Promoting Factor Enzymatic and Resuscitation Activity

(2009) Galina R. Demina et al.   PLoS One

Selective Killing of Nonreplicating Mycobacteria

(2008) Ruslana Bryk et al.   Cell Host & Microbe

A novel drug discovery concept for tuberculosis: Inhibition of bacterial and host cell signalling

(2008) Rita Székely et al.   IMMUNOLOGY LETTERS

Role of the dosR-dosS Two-Component Regulatory System in Mycobacterium tuberculosis Virulence in Three Animal Models

(2008) P. J. Converse et al.   INFECTION AND IMMUNITY

Nitrate Enhances the Survival of Mycobacterium tuberculosis during Inhibition of Respiration

(2008) C. D. Sohaskey   JOURNAL OF BACTERIOLOGY

Biosynthesis and Recycling of Nicotinamide Cofactors inMycobacterium tuberculosis

(2008) Helena I. M. Boshoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mycobacterial Enzyme Essential for Cell Division Synergizes with Resuscitation-Promoting Factor

(2008) Erik C. Hett et al.   PLoS Pathogens