Crosstalk between Signaling Pathways in Pemphigus: A Role for Endoplasmic Reticulum Stress in p38 Mitogen-Activated Protein Kinase Activation?

Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering

(2017) Kenji Yoshida et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial

(2017) Pascal Joly et al.   LANCET

Mechanisms of Autoantibody-Induced Pathology

(2017) Ralf J. Ludwig et al.   Frontiers in Immunology

Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus

(2017) Elias Walter et al.   Scientific Reports

Non-infectious environmental antigens as a trigger for the initiation of an autoimmune skin disease

(2016) Ye Qian et al.   AUTOIMMUNITY REVIEWS

Patients with pemphigus foliaceus may retain antibody reactivity against calcium-stabilized, distal desmoglein 1 domains in remission

(2016) C.M. Hammers et al.   BRITISH JOURNAL OF DERMATOLOGY

Anti-Desmoglein 1 and 3 Autoantibody Levels in Endemic Pemphigus Foliaceus and Pemphigus Vulgaris from Brazil

(2016) Liana Oliveira et al.   Clinical Laboratory

Endoplasmic reticulum stress is associated with the pathogenesis of pemphigus vulgaris

(2016) Chrysovalantou Mihailidou et al.   EXPERIMENTAL DERMATOLOGY

Monopathogenic vs multipathogenic explanations of pemphigus pathophysiology

(2016) A. Razzaque Ahmed et al.   EXPERIMENTAL DERMATOLOGY

Hepatitis B Virus Middle Protein Enhances IL-6 Production via p38 MAPK/NF-κB Pathways in an ER Stress-Dependent Manner

(2016) Yang-Xia Li et al.   PLoS One

Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis

(2015) Andreas Koeberle et al.   FASEB JOURNAL

Loss of Desmoglein Binding Is Not Sufficient for Keratinocyte Dissociation in Pemphigus

(2015) Franziska Vielmuth et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Large-Scale Electron Microscopy Maps of Patient Skin and Mucosa Provide Insight into Pathogenesis of Blistering Diseases

(2015) Ena Sokol et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

No Evidence of Apoptotic Cells in Pemphigus Acantholysis

(2014) Ineke C. Janse et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization

(2014) Z. Zhou et al.   PLACENTA

Pemphigus: a brief review

(2013) R. W. Groves   CLINICAL MEDICINE

Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering

(2013) Volker Spindler et al.   JOURNAL OF CLINICAL INVESTIGATION

MAPKAP Kinase 2 (MK2)-Dependent and -Independent Models of Blister Formation in Pemphigus Vulgaris

(2013) Xuming Mao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Treatment of severe autoimmune blistering skin diseases with combination of protein A immunoadsorption and rituximab: a protocol without initial high dose or pulse steroid medication

(2013) M. Kolesnik et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Ultrastructure of acantholysis in pemphigus foliaceus re-examined from the current perspective

(2012) G. van der Wier et al.   BRITISH JOURNAL OF DERMATOLOGY

The expression of dual-specificity phosphatase 1 mRNA is downregulated in lesional psoriatic skin

(2012) R.B. Kjellerup et al.   BRITISH JOURNAL OF DERMATOLOGY

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

(2012) Giovanni Di Zenzo et al.   JOURNAL OF CLINICAL INVESTIGATION

Pemphigus autoimmunity: Hypotheses and realities

(2011) Sergei A. Grando   AUTOIMMUNITY

Blasenbildende Autoimmundermatosen. Teil 2: Diagnostik und Therapie

(2011) Andrea Kneisel et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Down-regulation of Cytokine-induced Interleukin-8 Requires Inhibition of p38 Mitogen-activated Protein Kinase (MAPK) via MAPK Phosphatase 1-dependent and -independent Mechanisms

(2011) Nurlan Dauletbaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deregulation of PERK in the autoimmune disease pemphigus vulgaris occurs via IgG-independent mechanisms

(2010) A. Lanza et al.   BRITISH JOURNAL OF DERMATOLOGY

p38 Kinase Is Crucial for Osteopontin-Induced Furin Expression That Supports Cervical Cancer Progression

(2010) V. Kumar et al.   CANCER RESEARCH

p38 MAPK Activation Is Downstream of the Loss of Intercellular Adhesion in Pemphigus Vulgaris

(2010) Xuming Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective Endogenous Cyclic Adenosine 5'-Monophosphate Signaling Triggered by Pemphigus Autoantibodies

(2010) V. Spindler et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic Reticulum Stress-Mediated Apoptosis of EBV-Transformed B Cells by Cross-Linking of CD70 Is Dependent upon Generation of Reactive Oxygen Species and Activation of p38 MAPK and JNK Pathway

(2010) G. B. Park et al.   JOURNAL OF IMMUNOLOGY

Apoptosis in pemphigus

(2009) Enno Schmidt et al.   AUTOIMMUNITY REVIEWS

An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris

(2009) Maider Pretel et al.   EXPERIMENTAL DERMATOLOGY

Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis

(2009) Sergei A. Grando et al.   EXPERIMENTAL DERMATOLOGY

Antimitochondrial Autoantibodies in Pemphigus Vulgaris

(2009) Steve Marchenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of NF-κB-dependent Transcription by MKP-1

(2009) Elizabeth M. King et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Epitopes of Autoantibodies in Pemphigus Reside in the Amino-Terminal Adhesive Region of Desmogleins Which Are Unmasked by Proteolytic Processing of Prosequence

(2009) Mariko Yokouchi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autoantibodies in the Autoimmune Disease Pemphigus Foliaceus Induce Blistering via p38 Mitogen-Activated Protein Kinase-Dependent Signaling in the Skin

(2008) Paula Berkowitz et al.   AMERICAN JOURNAL OF PATHOLOGY

Apoptosis is not required for acantholysis in pemphigus vulgaris

(2008) Enno Schmidt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pemphigus and infectious agents

(2008) Lior Sagi et al.   AUTOIMMUNITY REVIEWS

Evidence of Key Role of Cdk2 Overexpression in Pemphigus Vulgaris

(2008) Alessandro Lanza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Induction of p38MAPK and HSP27 Phosphorylation in Pemphigus Patient Skin

(2007) Paula Berkowitz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY